Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2013.1411.1414TalghiniS. VahediAmir LotfiniaI. 1220131621It has been proposed that because there is inflammation around
the nerve roots in disk herniation, there might be an association between serum
C Reactive Protein (CRP) with this disease. This study aimed to distinguish
between two forms of disk herniation (extrusion, bulging) by comparing the level
of serum high-sensitivity CRP (hs CRP). In this perspective study, a total of
62 candidates for lumbar disk herniation surgery were recruited in Tabriz Imam
Reza Hospital from 2012 to 2013. The patients categorized in two groups; with
extrusion (n = 34) and with bulging (n = 28). Pre-operative serum hs CRP was
measured by turbidimetric immunoassay. Both extrusion and bulging groups were
matched for their patients sex
(males: 61.8% vs. 57.1%, respectively; p = 0.71) and age (mean: 52.22±7.32
years vs. 49.69±9.40 years, respectively; p = 0.48). The mean serum hs
CRP was significantly higher in the extrusion group (3.56±2.90 with a
range of 0.1 to 19 mg dL-1 vs. 0.74±0.91 with a range of 0
to 5 mg dL-1; p<0.001). Based on the results of the receiver operator
characteristics (ROC) cure, a cut-off point of hs CRP was =2.6 was highly indicative
of extrusion, with a sensitivity and specificity of 66 and 63%, respectively.
Based on the findings of the present study, the mean serum hs CRP is significantly
higher in the patients with extrusive disk herniation vs. those with bulging.
The proposed cut-off point may be useful as a preliminary indicator of the type
of herniation, before more detailed imaging becomes available.]]>Ackerman, W.E. III and J.M. Zhang,2006104295299Baradaran, A. and H. Nasri,20054175182Chao, Z., Z. Yue, C. Tong-Wei, W. Jian, H. Yong and P. Yong,200710311314Doita, M., T. Kanatani, T. Ozaki, N. Matsui, M. Kurosaka and S. Yoshiya,20012615221527Fardon, D.F. and P.C. Milette,200126E93E113Foglar, C. and R.W. Lindsey,199821687691Gabay, C. and I. Kushner,1999340448454Gronblad, M., J. Virri, S. Seitsalo, A. Habtemariam and E. Karaharju,20002528032807Haaga, J.R., D. Boll, V.S. Dogra, M. Forsting, R.C. Gilkeson, K.H. Ha and M. Sundaram,20085th Edn.,pp: 767-768pp: 767-768Kawaguchi, S., T. Yamashita, K. Yokogushi, T. Murakami, O. Ohwada and N. Sato,20012612091214Kawaguchi, S., T. Yamashita, G. Katahira, H. Yokozawa, T. Torigoe and N. Sato,20022715111516Le Gars, L., D. Borderie, G. Kaplan and F. Berenbaum,200067452455Moore, R.J.,200615S333S337Nasri, H., S. Shirani and A. Baradaran,200615964Pouriesa, M., R.F. Fouladi and S. Mesbahi,201313402407Sugimori, K., Y. Kawaguchi, M. Morita, I. Kitajima and T. Kimura,20038511511154Thompson, D., M.B. Pepys and S.P. Wood,19997169177Virri, J., M. Gronblad, S. Seitsalo, A. Habtemariam, E. Kaapa and E. Karaharju,20012623112315Woertgen, C., R.D. Rothoerl and A. Brawanski,200025871875Zhang, C., Y. Zhou, T.W. Chu, J. Wang, W.D. Wang and Y. Hao,20068630393042 [Article in Chinese]