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that imparts a foremost threat for cardiovascular and renal disorders. Mammoth
efforts are needed for the synthesis of innovative antihypertensive agents to
combat this lethal disease. Chalcones have shown antihypertensive activity through
inhibition of Angiotensin Converting Enzyme (ACE). Hence, a series of chalcone
analogues is synthesized and used as precursor for the synthesis of novel series
of pyrimidines. Precursor chalcones were prepared by reacting aldehydes and
ketones in presence of sodium hydroxide followed by synthesis of corresponding
pyrimidines by reaction with urea in presence of potassium hydroxide. Both groups
were then evaluated for their effects on ACE. The results depicted that pyrimidines
were more active than chalcones with methoxy (C5 and P5) substitution showing
best results to inhibit ACE. Given that chalcone analogues and pyrimidines show
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