Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2012.98.102Urtica dioica) Extract on Oxidative Stress in Patients with Type 2 Diabetes: A Randomized Double-blind Clinical Trial]]>NamaziN. TarighatA. BahramiA. 22012152Diabetes type 2 is a metabolic disorder that characterized
by hyperglycemia and insulin resistance. Hyperglycemia and impairment of oxidant/antioxidant
balance, can increase oxidative stress and increase risk of cardiovascular disease.
In the present study, Effects of hydro alcoholic extract of Nettle on oxidative
stress in type 2 diabetes were evaluated. Fifty patients (27 men, 23 women)
with type 2 diabetes patients were studied. They received 100 mg kg-1
of nettle extract of body weight hydro alcoholic for 8 weeks. At the baseline
and end of 8th weeks of intervention blood levels of oxidative stress markers
were measured. Data was analyzed by SPSS version 18, p<0.05 was considered
significant for all variables. After 8 weeks, Total Antioxidant Capacity (TAC)
and Superoxidant Dismutase (SOD) showed a significant increase in the intervention
group compared to the control group (p<0.05). The findings showed that the
hydro alcoholic extract of nettle has increasing effects on TAC and SOD in patients
with type 2 diabetes without no changes in Malondialdehyde (MDA) and Glutathione
Peroxides (GPX) after eight weeks intervention.]]>Abdel-Hamid, N.M., L.M. Faddah, M.A. Al-Rehany and A.A. Awad,200833237Ahmed, F.N., F.N. Naqvi and F. Shafiq,20061084481489Atalay, M. and D.E. Laaksonen,2002114Vincent, A.M., J.W. Russell, P. Low and E.L. Feldman,200425612628Annegowda, H.V., C.W. Nee, M.N. Mordi, S. Ramanathan and S.M. Mansor,2010Terminalia catappa L. leaf.]]>9479485Benzie, I.F.F. and J.J. Strain,19992991527Bitiren, M., D. Musa, A. Ozgonul, M. Ozaslan and A. Kocyigit et al.,2010Camelia sinensis), Hypericum perforatum and Urtica dioica on hepatic injury and lymphocyte DNA damage induced by carbon tetrachloride in wistar rats.]]>6241248Boots, A.W., G.R.M.M. Haenen and A. Bast,2008585325337Chrubasik, J.E., B.D. Roufogalis, H. Wagnerc and S. Chrubasik,200714423435Egede, L.E., X. Ye, D. Zheng and M.D. Silverstein,200225324329Rains, J.L. and S.K. Jain,201150567575Golalipour, M.J. and V. Khori,2007Urtica dioica leaves on blood glucose concentration and β-cells in streptozotocin-diabetic rats.]]>1012001204Gulcin, I., O.I. Kufrevioglu, M. Oktay and M.E. Buyukokuroglu,2004Urtica dioica L.).]]>90205215Hagstromer, M., P. Oja and M. Sjostrom,20069755762Idonije, O.B., O. Festus, O. Okhiai and U. Akpamu,2011Plasmodium falciparum and Plasmodium vivax malaria infection.]]>4506513Kanter, M., O. Coskun and M. Budancamanak,2005Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats.]]>1166846688Khan, A. and M. Safdar,20032112Mahmoud, A.H., H.M. Motawa, H.E. Wahba and A.Y. Ebrahim,2006Urtica pilulifera extracts.]]>16774Malekirad, A.A., N. Hosseini, M. Bayrami, T. Hashemi, K. Rahzani and M. Abdollahi,20116953957Namazi, N., A.T. Esfanjani, J. Heshmati and A. Bahrami,2011Urtica dioica) extracts on insulin sensitivity and some inflammatory indicators in patients with type 2 diabetes: A randomized double-blind control trial.]]>14775779Namazi, N., A.T. Esfanjani, M. Asghari and A. Bahrami,2011Urtica dioica) extracts on some cardiovascular risk factors in patients with type 2 diabetes.]]>11138144Nourmohammadi, I., S. Athari-Nikazm, M.R. Vafa, A. Bidari and S. Jazayeri et al.,2010106366Odukoya, O.A., S.I. Inya-Agha, F.I. Segun, M.O. Sofidiya and O.O. Ilori,20072169175Ozen, T. and H. Korkmaz,2003Urtica dioica L. (Urticaceae) leaf extract on biotransformation enzyme systems, antioxidant enzymes, lactate dehydrogenase and lipid peroxidation in mice.]]>10405415Pourmorad, F., S.J. Hosseinimehr and N. Shahabimajd,2006511421145Rasheed, Z., R. Ahmad, N. Rasheed, T. Tripathi and R. Ali,20082113Samsam-Shariat, S.,1980pp: 12-15pp: 12-15Toldy, A., K. Stadler, M. Sasvari, J. Jakus and K.J. Jung et al.,200565487493Yener, Z., I. Celik, F. Ilhan and R. Bal,2009Urtica dioica L. seed on lipid peroxidation, antioxidants and liver pathology in aflatoxin-induced tissue injury in rats.]]>47418424Karim, A., M.N. Sohail, S. Munir and S. Sattar,20117419439