Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2012.68.77Ahmed Amin SalehDina Ahmed IsmailMona Mohamed IbrahimAyman 22012152This study explores the occurrence of Non-alcoholic Fatty Liver Disease (NAFLD), Insulin Resistance (IR), dyslipidemia and atherogenic ratios in epileptic children and adolescents receiving Valproic Acid (VPA), Carbamazepine (CBZ) or both (combination therapy) compared to healthy controls. Abdominal Computerized Tomography (CT), measurements of serum fasting insulin, glucose, serum lipids and liver enzymes were performed in VPA (n = 14), CBZ (n = 14) or both (n = 10) treated non-diabetic non-obese epileptic patients compared to healthy controls (n = 10). Abdominal CT demonstrated characteristics of fatty liver disease in 42.8% of VPA, in 21.4% of CBZ, in 60% of combination therapy treated patients and none of the healthy controls. All of them were overweight and 53.3% had IR. In conclusion VPA therapy was associated with increased risk of IR and NAFLD, while CBZ therapy was associated with dyslipidemia and combination therapy was associated with all these risks.]]>Abdel-Wahab, B.A. and M.E. Metwally,20116679690Ahmad, M.,20111114Akbar, D.H. and A.H. Kawther,200612RA23RA26Almenabbawy, K.M., S.I. Helal, S.T. Zaki, O.M. Said, M.M. Salam, M.M. Abdelmoneim and L.M. Aboismaiel,20099234239Angulo, P.,200234612211231Ansari, J.A., M. Sayyed and F. Sayeed,20117579588Assmann, G., H. Schriewer, G. Schmitz and E.O. Hagele,19832920262030Bedogni, G., S. Bellentani, L. Miglioli, F. Masutti, M. Passalacqua, A. Castiglione and C. Tiribelli,200663333Carl, A., E.R. Ashwood and D.E. Bruns,20062006Pages: 2448Pages: 2448Chan, D.C., P.H. Barrett and G.F. Watts,2004107221232Chan, D.F., A.M. Li, W.C. Chu, M.H. Chan and E.M. Wong et al.,20042812571263ILAE,198930389399Cook, S., M. Weitzman, P. Auinger, M. Nguyen and W.H. Dietz,2003157821827Cotrim, H.P., R. Parana, E. Braga and L. Lyra,20009530183019Daniel, W.W.,19956th Edn.,Day, C.P.,200250585588De Onis, M., A.W. Onyango, E. Borghi, A. Siyam, C. Nishida and J. Siekmann,200785660667Demircioolu, S., A. Soylu and E. Dirik,200023142146Desouky, A.M., M. Raafat, A.A. Metwaly, A. El-Shamaa and E. Abdallah,20077503515Dietschy, J.M., L.E. Weeks and J.J. Delento,197673407407Edmison, J. and A.J. McCullough,20071175104Eiris, J., M.I. Novo-Rodriguez, M. Del-Rio, P. Meseguer, M.C. Del-Rio and M. Castro-Gago,20004117Eiris, J.M., S. Lojo, M.C. Del-Rio, I. Novo, M. Bravo, P. Pavon and M. Castro-Gago,19954511551157Engel, Jr., J.,200142796803Fichsel, H.,198062108108Fishbein, M., F. Castro, S. Cheruku, S. Jain, B. Webb, T. Gleason and W.R. Stevens,200539619625Franzoni, E., M. Govoni, S. D'Addato, S. Gualandi, Z. Sangiorgi, G.C. Descovich and G.P. Salvioli,199233932935Gastaldelli, A., M. Kozakova, K. Hojlund, A. Flyvbjerg, A. Favuzzi, A. Mitrakou And B. Balkau,20094915371544Haque, M. and A. Sanyal,2002200216709731Isojarvi, J.I., T.J. Laatikainen, M. Knip, A.J. Pakarinen, K.T. Juntunen and W. Myllyla,199639579584Isojarvi, J.I., J. Rattya, V.V. Myllyla, M. Knip and R. Koivunene et al.,199843446451Johannessen, C.U.,200037103110Kelishadi, R., S.R. Cook., A. Adibi, Z. Faghihimani and S. Ghatrehsamani et al.,200912929Keskin, M., S. Kurtoglu, M. Kendirci, M.E. Atabek and C. Yazici,2005115500503Khashab, M.A., S. Liangpunsakul and N. Chalasani, 2008107380Kocak, N., A. Yuce, F. Gurakan and H. Ozen,20009510991100Kodama, Y., C.S. Ng, T.T. Wu, G.D. Ayers and S.A. Curley et al.,200718813071312Luef, G.J., M. Lechleitner, G. Bauer, E. Trinka and P. Hengster,2003555358Luef, G.J., M. Waldmann, W. Sturm, A. Naser and E. Trinka et al.,200455729732Luoma, P.V., V.V. Myllyla and E. Hokkanen,1982410241027Mahajan, R., K. Gupta and V. Kapoor,20106338345Manco M, G. Bottazzo, R. De-Vito, M. Marcellini, G. Mingrone and V. Nobili,200827667676McGowan, M.W., J.D. Artiss, D.R. Strandbergh and B. Zak,198329538542Mofrad, P., M.J. Contos, M. Haque, C. Sargeant and R.A. Fisher et al.,20033712861292Mulhall, B.P., J.P. Ong and Z.M. Younossi,20021711361143National Cholesterol Education Program (NCEP),199489495501NHBPEP,2004114555576Nejad, S.E.M., M.R.A. Nikpour, F. Rahim, S.N. Naghibi and M.A. Bahrammi,20095313318Nikalje, A.P.G., M. Ghodke and A. Girbane,20114201220Oliva, M.R., K.J. Mortele, E. Segatto, J.N. Glickman, S.M. Erturk, P.R. Ros and S.G. Silverman,2006303743Park, H.S., J.H. Han, K.M. Choi and S. Kim,20058210461051Patton, H.M., C. Sirlin, C. Behling, M. Middleton, J.B. Schwimmer and J.E. Lavine,200643413427Pylvanen, V., M. Knip, A. Pakarinen, M. Kotila, J. Turkka and J.I. Isojarvi,200243514517Pylvanen, V., A. Pakarinen, M. Knip and J. Isojarvi,20068643648Ramzan, M., I. Ali and A. Matin,20098797799Reaven, G.,2002106286288Rockall, A.G., S.A. Sohaib, D. Evans, G. Kaltsas and A.M. Isidori et al.,2003149543548Ryan, C.K., L.A. Johnson, B.I. Germin and A. Marcos,2002811141122Schindhelm, R.K., J.M. Dekker, G. Nijpels, L.M. Bouter, C.D.A. Stehouwer, R.J. Heine and M. Diamant,2007191391396Schwimmer, J.B., R. Deutsch, J.B. Rauch, C. Behling, R. Newbury and J.E. Lavine,2003143500505Sonmez, F.M., E. Demir, A. Orem, S. Yildirmis, F. Orhan, A. Aslan and M. Topbas,2006217074Szczepaniak, L.S., P. Nurenberg, D. Leonard, J.D. Browning and J.S. Reingold et al.,2002288462468Targher, G. and G. Arcaro,2007191235240Targher, G., L. Bertolini, R. Padovani, F. Poli and L. Scala et al.,2006295560Tominaga, K., F. Fujimoto, K. Suzuki, M. Hayashi, M. Ichikawa and Y. Inaba,200914142149Treeprasertsuk, S., F. Lopez-Jimenez and K.D. Lindor,2011563545Verrotti, A., S. Agostinelli, P. Parisi, F. Chiarelli and G. Coppola,201120382385Verrotti, A., F. Basciani, M. De-Simone, D. Trotta, G. Morgese and F. Chiarelli,200217265268Verrotti, A., S. Domizio, B. Angelozzi, G. Sabatino, G. Morgese and F. Chiarelli,199733242245Verrotti, A., R. La-Torre, D. Trotta, A. Mohn and F. Chiarelli,200971125131Volzke, H., D.M. Robinson, V. Kleine, R. Deutscher and W. Hoffmann et al.,20051118481853Vorum, H., L. Gram and B. Honore,1993165564Warnick, G.R., R.H. Knopp and V. Fitzpatrick,1990361519Wieckowska, A., A.J. McCullough and A.E. Feldstein,200746582589WHO.,20062006Yalcin, E., A. Hassanzadeh and K. Mawlud,199739342345Zeitlhofer, J., A. Doppelbauer, G. Tribl, T. Leitha and L. Deecke,199371574578