Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2011.658.663NavaliNazli PourabolghasemShabnam FouladiRohollah FadaeiNikpourMehri Amiri1120111411Various classes of medication are currently being used in Polycystic Ovary Syndrome (PCOS) patients including the biguanides and the statins. However, their efficacies are rarely compared. This study aimed to compare efficacy of a biguanide and a statin in treating PCOS. In a randomized double-blind clinical trial, 400 women with PCOS were recruited within 15 months in Taleghani Hospital. They randomly received either a biguanide (metformin 500 mg three times daily) or a statin (simvastatin 20 mg daily) for three consecutive months. Changes of clinical and laboratory variables were compared. In the biguanide group the serum glucose status (abnormal fasting and non-fasting sugar and insulin levels and percentage of hyperinsulinemic cases) and menstrual abnormalities improved significantly after treatment (p<0.05). In the statin group the lipid profile status (abnormal total cholesterol, high and low density lipoproteins), C-Reactive Protein (CRP), serum dehydroepiandrosterone sulfate, hyperinsulinemia, severity of acne and menstrual abnormalities improved significantly after treatment (p<0.05). Comparing the two groups, the improvements in fasting blood sugar and serum insulin levels were significantly better in the biguanide group (p = 0.04 for both parameters); whereas the improvements in serum total cholesterol (p<0.001), low density lipoprotein (p<0.001), CRP (p<0.001) and acne status (p = 0.04) were significantly superior in the statin receivers. Based on these results, each medication is only effective on some aspects of the disease. Overall, the simvastatin was superior to metformin with regard to the number of beneficial effects.]]>Azziz, R., K.S. Woods, R. Reyna, T.J. Key, E.S. Knochenhauer and B.O. Yildiz,20048927452749Banaszewska, B., L. Pawelczyk, R.Z. Spaczynski, J. Dziura and A.J. Duleba,200792456461Banaszewska, B., L. Pawelczyk, R.Z. Spaczynski and A.J. Duleba,20099449384945Boomsma, C.M., B.C. Fauser and N.S. Macklon,2008267284Costello, M.F., B. Shrestha, J. Eden, N.P. Johnson and P. Sjoblom,20072212001209Cunningham, F., K. Leveno, S. Bloom, J. Hauth, D. Rouse and C. Spong,200923rd Edn.,Pages: 1404Pages: 1404De Leo, V., A. la Marca and F. Petraglia,200324633667Duleba, A.J., B. Banaszewska, R.Z. Spaczynski and L. Pawelczyk,2006859961001Farzadi, L.M.D. and S.M.D.S. Zadeh,20066765771Ghasemzad, A., L. Farzadi and O. Ajalli,20077991996Glueck, C.J., P. Wang, R. Fontaine, T. Tracy and L. Sieve-Smith,200129160169Goldenberg, N. and C. Glueck,2008606375Katzung, B.G.,20008th Edn.,Pages: 1217Pages: 1217Kaya, C., R. Pabuccu, S.D. Cengiz and I. Dunder,2010118161166Kazerooni, T., A. Shojaei-Baghini, S. Dehbashi, N. Asadi, F. Ghaffarpasand and Y. Kazerooni,20109422082213Kebapcilar, L., O. Bilgir, C.E. Taner, A.G. Kebapcilar and D.L. Kozaci et al.,2010281539543Kelly, C.C., H. Lyall, J.R. Petrie, G.W. Gould, J.M. Connell and N. Sattar,20018624532455Krotkiewski, M., K. Landin, E. Dahlgren, P.O. Janson and G., Holm,2003558895Kuscu, N.K. and F.M. Koyuncu,2002733Larsen, P.R., H.M. Kronenberg, S. Melmed, K.S. Polonsky, J.D. Wilson, D.W. Foster and H.M. Kronenberg,200210th Edn.,pp: 1820pp: 1820Petrie, A. and C. Sabin,20001st Edn.,pp: 1-7pp: 1-7Lee, E.J., K.J. Yoo, S.J. Kim, S.H. Lee and D.H. Choi et al.,20055832836Lo, J.C., S.L. Feigenbaum, J. Yang, A.R. Pressman, J.V. Selby and A.S. Go,20069113571363Luque-Ramirez, M., F. Alvarez-Blasco, J.I. Botella-Carretero, E. Martinez-Bermejo, M.A. Lasuncion and H.F. Escobar-Morreale,20079224532461Moghetti, P., R. Castello, C. Negri, F. Tosi and F. Perrone et al.,200085139146Ornstein, R.M., N.M. Copperman and M.S. Jacobson,20112011Palomba, S., A. Falbo, F. Orio and F. Zullo,200820364373Palacio, J.R., A. Iborra, Z. Ulcova-Gallova, R. Badia and P. Martinez,2006144217222Papaleo, E.,20112011Pasquali, R., A. Gambineri, D. Biscotti, V. Vicennati and L. Gagliardi et al.,20008527672774Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group,2004811925Sathyapalan, T., E.S. Kilpatrick, A.M. Coady and S.L. Atkin,200994103108Vrbikova, J., M. Hill, L. Starka and K. Vondra,200253100104Wild, R.A., S. Vesely, L. Beebe, T. Whitsett and W. Owen,20059041124114