Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2011.1066.1069Teucrium
oliverianum (A Plant Use in Southern Iranian Traditional Medicine) in Rat by Formalin Test]]>ArziA. NamjouyanF. SarahroodiS. KhorasganiZ. Nazari MacvandiE. 1220111423Objective: Antinociceptive and anti-inflammatory activities
of hydroalcoholic extract of Teucrium Oliverianum were investigated by
formalin test model. This study was conducted in on the male Wistar rats, weighting
150-180 g. The animals were divided into seven groups (n = 7) and recieved 200,
400, 600 and 800 mg kg-1 of hydroalcoholic extract of teucrium oliverianum
intraperitoneally, respectively. Negative control group received normal saline
(5 mL kg-1) and the positive control groups received 2.5 mg kg-1
morphine and 300 mg kg-1 aspirin, intraperitoneally respectively.
The results showed that all doses of extract have significant analgesic effect
(p<0.05) in all studies times in comparison with negative control. The best
result achieved with 600 mg kg-1 of extract. The result revealed
that the analgesic effect of the extract (600 mg kg-1) \was less
than aspirin (300 mg kg-1) on the second phase of pain and less than
morphine (2.5 mg kg-1) in both phases of the pain, more than aspirin
in first phase of pain. One group of animals was treated with naloxone (1 mg
kg-1, i.p.) and suitable dose of extract (600 mg kg-1,
i.p.). Also, Naloxone inhibited analgesic effect of alcoholic extract of Teucrium
Oliverianum. It can be concluded that the alcoholic extract of Teucrium
oliverianum may exert its effect through opioid receptors, stimulating GABAergic
system or promotes the release of endogenous opipeptides or decreasing free
radicals.]]>Almeida, R.N., R.N. Almeida, D.S. Navarro and J.M. Barbosa-Filho,20018310322Chevallier, A.,1996Dubuisson, D. and S.G. Dennis,19774161174Granger, R.E., E.L. Campbell and G.A. Johanston20051β 2γ 2L GABAA receptors.]]>6911011111Hunskaar, S. and K. Hole,198730103114Hunskaar, S., O.B. Fasmer and K. Hole,1985146976Khalid, S., W.M. Shaik Mossadeq, D.A. Israf, P. Hashim and S. Rejab et al.,2010In vivo analgesic effect of aqueous extract of Tamarindus indica L. fruits.]]>19255259Kabouche, A., Z. Kabouche, A. Ghannadi and S.E. Sajjadi,20071934Ljubuncic, P., S. Dakwar, I. Portnaya, U. Cogan, H. Azaizeh and A. Bomzon,2006Teucrium polium possess remarkable antioxidant activity in vitro.]]>3329338Lynch, M.A.,20048487136Peana, A.T., P. Rubattu, G.G. Piga, S. Fumagalli, G. Boatto, P. Pippia, M.G. De Montis,20067824712474Shibata, M., T. Ohkubo and H. Takahashi,198938347352Vukovic, N., T. Milosevic, S. Sukdolak and S. Solujic,2007Teucrium montanum.]]>41720Coll, J. and Y. Tandron,200465387392Tjolsen, A., O.G. Berge, S. Hunskaar, J.H. Rosland and K. Hole,199251517Leal, L.K.A.M., A.A.G. Ferreira, G.A. Bezerra, F.J.A. Matos and G.S.B. Viana,200070151159Karim, A., M.N. Sohail, S. Munir and S. Sattar,20117419439Sohail, M.N., A. Karim, M. Sarwar and A.M. Alhasin,2011Allium cepa L.): An alternate medicine for Pakistani population.]]>7736744Sohail, M.N., F. Rasul, A. Karim, U. Kanwal and I.H. Attitalla,2011611251152Sohail, F. and M.N. Sohail,2011Silybum marianum L. despite of its weedy nature is an important medicinal plant of NWFP, Pakistan.]]>7747748Sarahroodi, S. and A. Arzi,20099829832Sarahroodi, S., H.R. Rasekh, M. Kamali-Nejad and L. Safaeian,2009Juglans regia L. and diabetes mellitus in Iranian traditional medicine.]]>31924Sarahroodi, S., A. Arzi, A.F. Sawalha and A. Ashtarinezhad,201064852Arzi, A., M. Ahamehe and S. Sarahroodi,2011Lavandula officinalis on nicotine-induced convulsion in mice.]]>14634640