Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2010.1202.1207Citrullus colocynthis on Patients with Hyperlipidemia]]>RahbarA. R.NabipourI. 1220101324Citrullus colocynthis is one of the medical herbs that traditionally have been used as an antidiabetic medication in tropical and subtropical countries. The aim of this study was to investigate the hypolipidemic effect of Citrullus colocynthis beyond the hypoglycemic impact on human. One hundred dislipidemic patients were randomly divided into two groups namely treated (n = 50) group and placebo (n = 50) group. The subjects were treated daily by powdered seeds of Citrullus colocynthis (300 mg) and placebo for 6 weeks. The serums, TG, Chol, LDL-C, HDL-C, SGOT and SGPT were measured with enzymatic methods at the beginning and the end of the project. The significance of differences within these groups was calculated by Paired T-test and by analysis of covariance between them. There were significant differences within and between treated and placebo groups during our treatment in TG and in Cholesterol after intervention (p<0.05). A daily intake of 300 mg day-1 of powdered seeds of Citrullus colocynthis can lower the triglyceride and cholesterol concentration significantly in nondiabetic hyperlipidemic patients.]]>Abe, I., T. Seki, K. Umehara, T. Miyase and H. Noguchi et al.,2000268767771Dallak, M., M. Al-Khateeb, M. Abbas, R. Elessa and F. Al-Hashem et al.,2009In vivo, acute, normo-hypoglycemic, antihyperglycemic, insulinotropic actions of orally administered ethanol extract of Citrullus colocynthis (L.) schrab pulp.]]>5118125American Diabetes Association,200326S83S86Anderson, K.M., P.W. Wilson, P.M. Odell and W.B. Kannel,199183356362Atole, S.K., C.R. Jangde, P. Philip, D.S. Rekhe, D.V. Aghav, H.J. Waghode and A.M. Chougule,2009Citrullus colocynthis for diabetes in rats.]]>2423425Barth, A., D. Muller and K. Durrling,2002In vitro investigation of a standardized dried extract of Citrullus colocynthis on liver toxicity in adult rats.]]>54223230Brattsand, R.,1975224761Chan, P.T., W.P. Frog, Y.L. Cheung, Y. Huang, W.K.K. Ho and Z.Y. Chen,1999Mescoricetus auratus) fed a high fat diet.]]>12910941101Chaturvedi, M., P.C. Mali and A.S. Ansari,2003Citrullus colocynthis Schrad fruit in male rats.]]>683848Daradka, H., M.M. Almasad, W.S. Qazan, N.M. El-Banna and O.H. Samara,2007Citrullus colocynthis L. in rabbits.]]>1027682771Dehghani, F. and M.R. Panjehshahin,2006Citrullus colocynthis on rat liver.]]>5117119Delazar, A., S. Gibbons, A. Kosari, H. Nazemiyeh, M. Modarresi, L. Nahar and S. Sarker,2006Citrulus colocynthis.]]>14109114Diwan, F.H., I.A. Abdel-Hassan and S.T. Mohammed,20006345351Huseini, H.F., F. Darvishzadeh, R. Heshmat, Z. Jafariazar, M. Razali and B. Larijani,2006Citrullus colocynthis (L.) schrad fruit in treatment of type II diabetic patients: A randomized, double blind, placebo-controlledstudy.]]>53135Goldfain, D., A. Lavergne, A. Galian, L. Chauveinc and F. Prudhomme,19893014121418Harada, U., A. Chikma, S. Saito, H. Takase, T. Nago, T. Hase and I. Tokimitsu,200551248252Jahromi, M.A.F., A.B. Ray and J.P.N. Chansouria,1993Pterocarpus marsupium.]]>56989994Kumar, S., D. Kumar, M. Jusha, K. Saroha, N. Singh and B. Vashishta,2008Citrullus colocynthis (L.) Schrad. methanolic fruit extract.]]>58215220Matsuda, H., Y. Li, J. Yamahara and M. Yoshikawa,1999289729734Nmila, R., R. Gross, H. Rchid, M. Roye and M. Manteghetti et al.,2000Citrullus colocynthis fruit extracts.]]>66418423O`Brien, T., T.T. Nquyen and B.R. Zimmerman,199873969976Reaven, E., D. Wright, C.E. Mondon, R. Solomon, H. Ho and G.M. Reaven,198332175180Abdel-Rahman, M.K., E.M. Mahmoud, A.R. Abdel-Moemin and O.G.A. Rafaat,2009818Sherlock, S.,19982217233Smith, S.C., R. Jackson, T.A. Pearson, V. Fuster and S. Yusuf et al.,200410931123121Sukandar, E.Y., H. Permana, I.K. Adnyana, J.I. Sigit, R.A. Ilyas, P. Hasimun and D. Mardiyah,2010Curcuma longa L.) and garlic (Allium sativum L.) extracts as antihyperglycemic and antihyperlipidemic agent in type-2 diabetes-dyslipidemia patients.]]>6456463Trease, G. and W. Evans,1970pp: 210-234pp: 210-234Yoshikawa, M., T. Morikawa, H. Kobayashi, A. Nakamura, K. Matsuhira, S. Nakamura and H. Matsuda,2007Citrullus colocynthis.]]>55428434USDA,2006