Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2009.809.812Helicobacter pylori]]>AminiM. TajikA. 1020091210The aim of this study was to determine the efficacy of oral regimens in patients without active gastric bleeding and those of intravenous regimens in a group with active gastric bleeding. This study was performed as an interventional investigation in Tehran between April 2004 and March 2008. The patients who had active peptic ulcer were included and divided into two groups. One group included 26 subjects with active gastric bleeding and the other included 29 patients without active gastric bleeding. The intravenous treatment included metronidazole, ampicillin, ranitidine and orally administered bismuth for five days. The oral regimen included metronidazole, amoxicillin, ranitidine and bismuth sub-citrate for 14 days. In intravenous group 24 patients (92.3%) and in oral group 24 subjects (82.8%) had no drug adverse events. The successful treatment was seen in 61.5% (16/26) and 55.2% (16/29) in intravenous and oral methods, respectively. Finally, it may be concluded that both five-day intravenous therapeutic regimen in patients with active gastric bleeding and 14-day oral regimen in patients without active gastric bleeding would have good efficacy and low rate of drug adverse events.]]>Adamek, R.J., M. Wegener, J. Labenz, M. Freitag, W. Opferkuch and G.H. Ruhl,1994Helicobacter pylori eradication therapy.]]>893942Amini, M., H. Khedmat and F. Yari,2005Helicobacter pylori in dyspeptic patients.]]>11193195Bafandeh, Y., H. Esmaeeli and S. Aharizad,2005Helicobacter pylori infection rates in duodenal ulcer patients in a population with high prevalence of infection.]]>24130130Barkun, A., C.A. Fallone, N. Chiba, N. Flook and J. Martin et al.,200418605609Jafarzadeh, A., M.T. Rezayati and M. Nemati,2007H. pylori and cagA in healthy children and adults (South-East of Iran).]]>1331173121Ley, L.M., A. Becker, R. Luhmann, P. Sander and P.W. Lucker,2005272529Metz, D.C., F. Amer, B. Hunt, M. Vakily, M.J. Kukulka and N. Samra,2006 6.0: An evaluation of intermittent oral and continuous intravenous infusion dosages.]]>23985995Novis, B.H., G. Gabay and T. Naftali,1998Helicobacter pylori: The middle East scenario.]]>71135141Rhead, J.L., D.P. Letley, M. Mohammadi, N. Hussein and M.A. Mohagheghi et al.,2007Helicobacter pylori vacuolating cytotoxin determinant, the intermediate region, is associated with gastric cancer.]]>133926936Romero Gómez, M., C. Martínez Delgado, L. Grande, M.A. Otero Fernandez, J. Vargas and M. Castro Fernandez,2000Helicobacter pylori infection.]]>92386391Romero-Gómez, M., C. Martínez-Delgado, P. Hergueta, J.M. Navarro and A. Garrido-Serrano et al.,2003Helicobacter pylori infection in patients with bleeding gastro-duodenal ulcer.]]>1810231029Ruiz Gómez, F.A., F.J. Sanchez Serrano, A. Martínez Egea, G. García Del Castillo, J. Sanchez Cuenca and M. Coronas Planas,2002Helicobacter pylori eradication therapy is highly effective in patients with bleeding peptic ulcer.]]>25383386Sheu, B.S., C.H. Chi, H.B. Yang, C.M. Jen and X.Z. Lin,1999H. pylori-positive bleeding duodenal ulcer.]]>4623632371Siavoshi, F., A.H. Salmanian, F. Akbari, R. Malekzadeh and S. Massarrat,2005Helicobacter pylori-specific genes in the oral yeast.]]>10318322