Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2009.64.68MoslemizadehN. Galini MoghadamT. PeyvandiS. 12009121The goal of this study was to evaluate the effect of
misoprostol on pregnancy rate after intrauterine insemination. This randomized
double blind clinical trial study was performed on 66 (33 cases and 33
controls) infertile women who referred to infertility center of Imam Khomeini
Hospital Sari, Iran for intrauterine insemination during 2006-2007. The
two groups were matched for age, infertility causes and BMI. After intrauterine
insemination, 200 mcg misoprostol was placed in posterior fornix of case
group and a similar placebo tablet in control group. Chemical and clinical
pregnancies and complications were recorded. Results were analyzed by
means of SPSS 11 software, paired t-test and student t-test. The p-values
of less than 0.05 were considered to be statistically significant. Chemical
pregnancy (positive BHCG) occurred in 6 patients (18.2%) in each group.
Clinical pregnancy occurred in 5 patients (15.15%) in case and 6 patients
(18.2%) in controls. There were no significant statistical differences
in complications between the two groups. Vaginal misoprostol after intrauterine
insemination does not improve pregnancy rate.]]>Aref, I. and E.S. Hafez,197614658664Asplund, J.,194713103107Barroso, G., S. Karchmer, E. Castelazo, E. Carballo and A. Kably,200169346350Berek, J.S.,200714th Edn.,pp: 1186-1275pp: 1186-1275Billiet, K., M. Dhont, C.V. Ervaet, A. Vermeire, J. Gerris, D. De Neubourg, L. Delbeke, W. Ombelet and P. De Sutter,200866145151Breyer, R.M., C.R.J. Kennedy, Y. Zhang and M.D Breyer,2000905221231Brown, S.E., J.P. Toner, J.A. Schnorr, S.C. Williams, W.E. Gibbons, D. de Ziegler and S. Oehninger,20011696101Bendvold, E., K. Svanborg, P. Eneroth, C. Gottlieb and M. Bygdeman,198441743747Bendvold, E., C. Gottlieb, K. Svanborg, M. Bygdeman and P. Eneroth,198710463469Bygdeman, M., B. Fredricsson, K. Svanborg and B. Samuelsson,197021622629Cong, J., H.L. Diao, Y. zhao and H. Ni,2006131139151Conte, D., M. Nordio, F. Romanelli, F. Manganelli, P. Giovenco, F. Dondero and A. Isidori,19858289291Centola, G.M. and K.A. Ginsburg,20041st Edn.,pp: 29pp: 29Centola, G.M. and P.M. Zavos,19912335339Ransom Scott, B.B., P. Michell, S. Dombrowski, M.N. Gene, K.S. Moghissi and A.R. Munkarah,20001st Edn.,pp: 645-646pp: 645-646Gibbs, R.S., B.Y. Karlan, A.F. Haney and I.E. Nygaard,200810th Edn.,pp: 706pp: 706Jakobsson, P.J., S. Thoren, R. Morgenstern and B. Samuelsson,19999672207225Katzung, B.G.,20049th Edn.,pp: 311pp: 311Kelly, R.W., A.J. Quayle, E.M. Wallace, F.C. Wu, T.B. Hargreave and K. James,199142257260Kennedy, J.H., N. Korn and R.J. Thurston,200317474Lu, S., R. Wa and Z. Wang,200136625627Lim, H., R.A. Gupta, W.G. Ma, B.C. Paria, D.E. Moller and J.D. Morrow et al.,19991315611574Murakami, M., H. Naraba, T. Tanioka, N. Semmyo, Y. Nakatani and F. Kojima et al.,20002753278332792Ni, H., T. Sun, X.H. Ma and Z.M. Yang,200368744750Tanioka, T, Y. Nakatani, N. Semmyo, M. Murakami and I. Kudo,20002753277532782Templeton, A., I. Cooper and R. Kelly,197852147150Yavas, Y. and R. Selub,20048216381647Zeyneloglu, H.B., T. Bagis, A. Lembet, T. Ergin and E. Kuscu,2002785555