Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2009.173.177AzzaouiF.Z. AhamiA.O.T. KhadmaouiA. 22009122The aim of this research was to investigate the impact
of lead nitrate administered in drinking water during 90 days (sub-chronic
toxicity), on body weight gain, motor activity, brain lead accumulation
and especially on recognition memory of Wistar rats. Two groups of young
female Wistar rats were used. Treated rats received 20 mg L-1
of lead nitrate diluted in drinking water, while control rats received
drinking water only, for 3 months. An evolution of body weight, motor
activity, object recognition memory and measure of brain lead levels has
been evaluated. The body weight was taken weekly, whereas the memory abilities
and the motor activity are measured once every fortnight alternatively,
by submitting rats to the Open Field (OF) test and to the Novel Object
Recognizing (NOR) memory test. The results have shown a non significant
effect in gain of body weight. However, a high significance was shown
for horizontal activity (p<0.01), long memory term (p<0.01), at
the end of testing period and for brain lead levels (p<0.05) between
studied groups.]]>Broadbent, N.J., L.R. Squire and R.E. Clark,20041011451514520Brody, D.J., J.L. Pirkle, R.A. Kramer, K.M. Flegal, T.D. Matte and E.W. Gunter,1994272277283Booze, R.M., C.F. Mactutus, Z. Annau and H.A. Tilson,19835367375Clark, R.E., S.M. Zola and L.R. Squire,20002088538860Cory-Slechta, D.A., B. Weiss and C. Cox,198959139150Cory-Slechta, D.A.,199535391415Coulehan, J.L., W. Hirsch, J. Brillman, J. Sanandria and T.K. Welty et al.,198371113117De Lima, M.N., T. Luft, R. Roesler and N. Schröder,2006405142146De Lima M.N., M. Polydoro, D.C. Laranja, F. Bonatto, E. Bromberg, J.C. Moreira, F. Dal Pizzol and N. Schroder,20052125212528Ennaceur, A., S. Michalikovaa, A. Bradforda and S. Ahmed,2004159247266Hammond, R.S., L.E. Tull and R.W. Stackman,2004822634Jett, D.A., A.C. Kuhlmann, S.J. Farmer and T.R. Guilarte,199757271279Konat, G. and J. Clausen,19744236424Louis, E.D., E.C. Jurewicz, L. Applegate, P. Factor-Litvak and M. Parides et al.,200311117071711Luthman, J., A. Oskarsson, L. Olson and B. Hoffer,199258236252Ma, T., H.H. Chen and I.K. Ho,1999105111121Muldoon, S.B., J.A. Cauley, L.H. Kuller, L. Morrow, H.L. Needleman, J. Scott and F.J. Hooper,1996156272Murphy, K.J. and C.M. Regan,19997220992104Payton, M., K.M. Riggs, A. Spiro, S.T. Weiss and H. Hu,1998201927Pinta, M.,19801st Edn.,Reddy, G.R., M.R. Basha, C.B. Devi, A. Suresh and J.L. Baker et al.,200321347352Rossouw, J., J. Offermeier and J.M. van Rooyen,198791132139Salinas, J.A. and N.C. Huff,200224551557Tang, H.W., Y.X. Liang, X.H. Hu and H.G. Yang,199582329Trombini, T.V., C.G. Pedroso, D. Ponce, A.A. Almeida and A.F. Godinho,200168743751Vnek, N. and L.A. Rothblat,19961627802787Winder, C. and S. Lazareno,198524209214Winneke, G., H. Lilienthal and U. Kramer,1996185770