Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2008.2505.2508BehrashiM. MahdianM. 1220081121The purpose of this study was to compare the efficacy
and side effects of two different misoprostol regimens for second-trimester
pregnancy termination. Sixty women in second trimester of gestation with
indications for pregnancy termination were randomly assigned in two equal
groups to receive either vaginal or oral misoprostol. The dosing regimen
was 400 μg as the initial dose followed by 400 μg up to 3 doses
(1200 μg) if needed in each group. Efficacy and side effects were
compared. The percentage of women who delivered was significantly higher
in vaginal group than the oral group (86.7 vs. 43.3 p = 0.0006). No significant
differences in complication rates and induction to delivery interval were
noted between the two groups. Vaginal administration of misoprostol resulted
in a higher success rate for second trimester pregnancy termination, whereas,
no significant differences in induction to delivery time and complication
rates were noted between vaginal and oral groups.]]>Bebbington, M.W., N. Kent, K. Lim, A. Gagnon and M.F. Delisle et al.,2002187853857Beucher, G., T. Beillat and M. Dreyfus,200332521Cunningham, F.G., K.J. Leveno, S.L. Bloom, J.C. Hauth and L.C. Gilstrap et al.,200522nd Edn.,Daskalakis, G.J., S.A. Mesogitis, N.E. Papantoniou, G.G. Moulopoulos and A.A. Papapanagiotou et al.,20051129799Dickson, J.E.,2005105352356Elsheikh, A., A. Antsaklis, S. Mesogitis, N. Papantoniou and A. Rodolakis et al.,2001265204206Feldman, D.M., A.F. Borgida, J.F. Rodis, M.V. Leo and W.A. Campbell,2003189710713Gilbert, A. and R. Reid,200141407410Muffley, P.E., M.L. Stitely and R.B. Gherman,2002187321326Nayki, U., C.E. Taner, T. Mizrak, C. Nayki and G. Derin,200520469471Ramsey, P.S., K. Savage, T. Lincoln and J. Owen,2004104138145Saha, S., R.S. Bal and P. Ghosh,20061048182