Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2008.2274.2277MeybodiM.A. Afkhami-ArdekaniM. RashidiM. 1220081118This study was performed to estimate prevalence of transaminase
levels in type 2 diabetic patients and identify contributing risk factors.
In this cross-sectional study 348 patients with type 2 diabetes, who attended
the diabetic clinic of Yazd Diabetes Research Center, were studied from
October 2004 to December 2005. Patients with history of viral hepatitis,
alcohol abuse and use of drug such as Amiodarone, Bleomycin, methotrexate,
tamoxifen and sodium valporate was excluded. To examine the relationships
between ALT, AST in individuals with type II diabetes and relation to
various metabolic parameters like triglyceride, cholesterol, age, duration
of diabetes, gender and BMI. Of 348 patients that entered the study, mean
age was 58.8 ± 11.5. Elevated ALT and AST were found in 10.4 and
3.3% of type 2 diabetic patients, respectively. Although the prevalence
of elevated ALT increased with increasing age, FBS and triglyceride levels
in subjects, but it was not statistically significant. There was a significant
association between elevated ALT and gender as well as diabetes duration.
The prevalence of elevated of ALT in type 2 diabetic patients is 1.6 times
higher than general population in Iran unrelated to age, BMI, glycemic
control, triglyceride levels. Identification risk factors and mechanisms
of these elevations are very important and require further evaluation.]]>American Diabetes Association,200427S15S35Clark, J.M. and A.M. Diehl,2003124248250Daniel, S., T. Ben-Menachem, G. Vasudevan, C.K. Ma and M. Blumenkehl, 19999430103014Davila, J.A., R.O. Morgan, Y. Shaib, K.A. McGlynn and H.B. El-Serag, 200554533539De Marco, R., F. Locatelli, G. Zoppini, G. Verlato, E. Bonora and M. Muggeo,199922756761El-Serag, H.B., T. Tran and J.E. Everhart,2004126460468Erbey, J.R., C. Silberman and E. Lydick,2000109588590Hermos, J.A., S.A. Cohen, R. HALL, D.R., Gagnon, M.T. Brophy and L.D. Fiore,200880153158Kaplan, M.M.,20021374951Mohamadnejad, M., A. Pourshams, R. Malekzadeh, A. Mohamadkhani and A. Rajabiani et al.,2003923222324Piton, A., T. Poynard, F. Imbert-Bismut, L. Khalil, J. Delattre, E. Pelissier, N. Sansonetti and P. Opolon,19982712131219Prati, D., E. Taioli, A. Zanella, E.D. Torre, S. Butelli and E. Del-Vecchio et al.,.200213719Salmela, P.I., E.A. Sotaniemi, M. Niemi and O. Maentausta,19847248254Shaib, Y.H., H.B. El-serag, J.A. Davila, R. Morgan and K.A. McGlynn,2005128620626Trombetta, M., G. Spiazzi, G. Zoppini and M. Muggeo,2005222427Wannamethee, S.G., A.G. Shaper, L. Lennon and P.H. Whincup,20052829132918West, J., J. Brousil, A. Gazis, L. Jackson, P. Mansell, A. Bennett and G.P. Aithal,200699871876