Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2008.1405.1413FerzandRubina Ali GadahiJavaid SalehaShamim AliQurban 1120081111Histological and hematological disturbance caused by Arsenic containing
water were studied in mice model. Animal were divided into four groups.
Control group exposed to arsenic free distilled water and 3 treatmental
group exposed to the arsenic containing water with 30, 150 and 300 ppb.
Blood samples and organs were collected after 40 days. Histopathological
results revealed mild to severe type of necrosis and degenerative changes
in kidney and liver of arsenic feed animals. Kidney of the 300 ppb group
showed severe type of necrosis and degenerative changes in distal and
proximal tubules. The renocytes of proximal and distal tubules were showing
hydropic and fatty degeneration. Due to degenerative changes cells were
showing cytoplasmic vacoulation and cytoplasmic and nuclear blebbing.
Glomeruli cells were contracted and increased the bowman`s spaces. Varied
degrees of changes were also observed in 30 and 150 ppb exposed group.
Necrosis of hepatocytes and cytoplasmic blebbing were also observed. The
sinusoidal spaces were expanded due to shrinkage and necrosis of hepatocytes.
Spleenocytosis occurred in spleen and the parenchymal and mesenchymal
cells were replaced by connective tissue. The lymphocytes were severely
damaged by arsenic toxicity. White Blood Cells (WBCs), Red Blood Cells
(RBCs) and hemoglobin level in control groups were in normal range where
as level were significantly decreased with the increase dose of arsenic
in the respective treatmental groups. The data was analyzed statistically
and was found that significant was found among the group (p < 0.05).]]>Agency for Toxic Substances and Disease Registry (ATSDR),19981998Aposhian, H.,199737397419Breton, A., V. Carrie, A. Houseman, L.M. Kile, Q. Quamruzzaman, M. Rahman, G. Mahiuddin and C. Christiani,200615902907Cullen, N., L.R. Wolf and St. Clair,199513432435Department of Environmental Quality,20032003Fuente, D., P. Perez, Baranda, D. Barriga, S. Alanis, Layseca and G. Amaro,20021296977Gupta, R. and S.J.S. Flora,2006Hippophae rhamnoides L. against arsenic toxicity in Swiss albino mice.]]>25285295Gupta, R., Dubey, Kannan and Flora,2007314456Hathaway, G.J., N. Proctor and J.P. Hughes,19913rd Edn.Hirata, M. and A. Tanaka,1990106469481Ishinishi, N., K. Tsuchiya, M. Vahter and B.A. Fowler,19862nd Edn.pp: 43-83.pp: 43-83.Kahlown, M., Tahir, H. Rasheed and I. Anwar,2003pp: 10-20pp: 10-20Labadie, H., P. Stoessel, P. Callard and M. Beaugrand,19909911401143Mahieu, P., J.P. Buchet, H.A. Roels and R. Lauwerys,19812O3. Its Significance for the duration of BAL therapy.]]>1810671075Marafante, E., M. Vahter and J. Envall,198556225238Marafante, E., M. Vahter, H. Norin, J. Envall, M. Sandstrom, A. Christakopoulos and R. Ryhage,19877111117Rousselot, P., J. Larghero, S. Lambaune, J. Poupon, M. Chopin, C. Dosquet, J.P. Marolleau, A. Janin, J.C. Brouet and J.P. fermand,200472166171Roy, S. and S. Bhattacharya,2006Channa punctatus.]]>65218229Sakurai, T., C. Kojima, M. Ochiai, T. Ohta and K. Fujiwara,2004in vivo acute immunotoxicity of a major organic arsenic compound arsenobetaine in seafood.]]>4179184Santra, A., A. Chowdhury, S. Ghatak, A. Biswas and G.K. Dhali,2007220146155Somia, B., Y. Sharma, M. Irshad, S. Gupta and T.D. Dogra1,2006983843Tahir, M.A.,20002000WHO., 19932nd Edn.,Zakharyan, R., Y. Wu, G.M. Bogdan and H.V. Aposhian,1995810291038