Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2008.1114.1119SarkakiAlireza AmaniReza BadaviMohammad Z. MoghaddamAhmad AligholiHadi SafahaniMaryam H. HaghighizadehMohammad 82008118The aim of this study was to evaluate the effects of different doses
of dietary soy meals (with or without isoflavone) on dementia in ovariectomized
(OVX) animal model of Alzheimer`s disease. Female Wistar`s rats with the
exception of intact group were ovariectomized at the first line of study.
Animals were divided into 2 main groups: control (c) and pre-treatment
groups. Animals in pre-treatment groups received one of five types of
diet during four weeks prior Nucleus Basalis Magnocellularis (NBM) electrical
lesion normal diet (0), 10 g soy with isoflavone (10), 20 g soy with isoflavone
(20), 10 g soy without isoflavone (-10) and 20 g soy without isoflavone
(-20) in 30 g daily diet. The spatial learning and memory were tested
using Morris water maze after electrical lesion. Rats were trained in
water maze to find a hidden escape Platform. Rats received 6 blocks that
each block consisted of 3 trials. Following acquisition trials, one probe
trial was conducted in which the platform was removed. Soy meal diet (with
or without isoflavone) in ovariectomized rats with Alzheimer`s disease
caused improvement of performance across 18 trials of Acquisition. Our
results suggest that soy meal is a potential alternative to estrogen in
the prevention and treatment of Alzheimer`s disease.]]>Auld, D., T. Kornecook, S. Bastianetto and R. Quirion,200268209245Bang, O., H. Hong, D. Kim, J. Boo, H. Kyoon and I. Mook-Jung,2004162128Behl, C.,199957301323Berrino, F.,200226107115Braunwald, E., K.J. Isselbacher, R.G. Petersdorf, G.D. Wilson, G.B. Martin and D. Fauci,198714th Edn.,pp: 1820-1829pp: 1820-1829Celec, P., D. Ostatnikova, M. Caganova, S. Zuchova and J. Hodosy et al.,200436266Chang, S.K.,20022002pp: 39-62pp: 39-62Cyr, M., F. Calon, M. Morissette and T. Paolo,2002271227Daniel, J.M. and C.D. Lee,200482142149Day, M. and M. Good,2004831321El-Bakri, N.K., A. Islam, S. Zhu, A. Elhassan, A. Mohammed, B. Winblad and A. Adem,20048537544Epizorno, G. and M. Murray,19992nd Edn.pp: 953-963pp: 953-963Fernandez, S.M. and K.M. Frick,200411813401351Frank, A.A., L.S. Custer, W. Wang and C.Y. Shi,1998217263274Gauthier, A. and R. Quirion,2001357396Greenberg, D.,20024th Edn.pp: 48-51pp: 48-51Heikkinen, T., J. Puoliväli and H. Tanila,20043912771283Holscher, C.,19985129141Ishunina, T., B. Fisser and D. Swaab,200122417426Kandel, E.R., J.H. Schwartz and T.M. Jessell,20004th Edn.,pp: 1228-1245pp: 1228-1245Kim, H., H. Xia, L. Li and J. Gewin,200012243250Kritz-Silverstein, D., D. von Muhlen, E. Barrett-Connor and M.A. Bressel,200310196202Lannfelt, L., R. Folkesson, A.H. Mohammed, B. Winblad, D. Hellgren, K. Duff and J. Hardy,199357207213Lassmann, H.,199678914Lee, Y.B., H.J. Lee, M.H. Won, I.K. Hwang, T.C. Kang and J.Y. Lee,200413718271831Lephart, E.D., T.W. West, K.S. Weber, R.W. Rhees, K.D.R. Setchell, H. Adlercreuz and T.D. Lund,200224516Lund, T.D., T. West, L. Tain, L. Bu and D. Simmons et al.,20012113Markham, J., J.C. Pych and J.M. Juraska,200242284293Morris, J.200317245258Norris, C.M. and T.C. Foster,199971194206Pan, Y., M. Anthony and T.B. Clarkson,1999221118125Paxinos, G. and C. Watson,19862nd Edn.,Perez, R.,19983378380Ramassamy, C., D. Averill, U. Beffert, L. Theroux and S. Lussier et al.,200072337Tanzi, R., D. Kavacs, T. Kim, R. Moir, S. Guenette and W. Wasco,19963159168Wisniewski, T., J. Ghiso and B. Frrangione,19974313328Zeng, H., Q.I. Chen and B. Zhao,200436180188Green, P.S. and J.W. Simpkins,200018347358