Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2007.2704.2708MoazediA. A.GhotbeddinZ. ParhamG. H.1220071016The aim of the present study was to evaluate the effects of dose-dependent of zinc chloride on short-term and long-term memory in a shuttle box. Young Wistar rats (94±10 g) (age 27-30 days) consumed zinc chloride drinking water in five different doses (20, 30, 50, 70 and 100 mg kg-1day-1) for two weeks by gavage. After 14 days on experimental diets, a shuttle box used to test short- and long-term memory. Two criteria considering for behavioral test, including latency in entering dark chamber and time spent in the dark chamber. This experiment shows that after 2 weeks oral administration of ZnCl2 with (20, 30 and 50 mg kg-1 day-1) doses, the rats working (short-term) has been improved (p<0.05). Whereas ZnCl2 with 30 mg kg-1 day-1 dose has been more effected than other doses (p<0.001). But rat which received ZnCl2 with 100 mg kg-1 day-1, has been shown significant impairment in working memory (p<0.05) and there was no significant difference in reference (long-term) memory for any of groups. In general, this study has demonstrated that zinc chloride consumption with 30 mg kg-1 day-1 dose for two weeks was more effective than other doses on short-term memory. But consumption of ZnCl2 with 100 mg kg-1 day-1 dose for two week had the negative effect on short-term memory. On the other hand, zinc supplementation did not have an effect on long-term memory.]]>Arlene, C., W.A. Rodringuez and T.P. Wright,199721649658Baskys, A., J.N. Reynolds and P.L. Carlen,2000530142146Brown, C.E. and R.H. Dyck,2005134355359Chu, Y., M.F. Mouat and A. Grider,200378569578Edward, S., D. Halas and D. Hunt,200037451458Eugenio, M., B.F. Carlo, M. Fiorella and M. Malavolta,200575367390Filinn, J.M., D. Hunter and D.H. Kinkous et al.,200583793803Karen, A. and A. Julie,200113016331640Chowanadisai, W., S.L. Kelleher and M. Lonnerdal,200594510519Li, Y., C.J. Hough, C.J. Frederickson, J.F. Christopher, and M.S. John,20012180158025Li, J., B. Yan, X. Zhao and C. Wang,200433559561Maureen, M., S. Sunil, K. Sonu, J. Kumar and V. Menon,200411312971304Ono, S. and M.G. Cherian,199969151159Pang, Z. and D.S. Wang,199950649655Patenaude, C., S. Nurse and J.C. Lacaille,2002412939Pfeiffer, C. and E. Braveman,200017513532Penland, J.G., H.H. Sandstead, N.W. Alcock, H.H. Dayal and X.C. Chen et al.,199716268272Takeda, A.,200034137148Takeda, A., S. Takefuta and S. Takefuta et al.,2000859352357Takeda, A., A. Minami and Y. Seki,200475225229Takeda, A., H. Tamano, M. Tochigi and N. Oku,200546221225Cole, T.B., A. Martyanova and R.D. Palmiter,2001891253265Turner, T.Y. and M. Soliman,20001) receptor binding kinetics in rats.]]>2412031217Tonder, N., F.F. Johansen, C. Erickson, J. Zimmer and N.H. Diemer,1990109247252Tuula, E.,199510149164