Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2007.1213.1220FouzyA.S.M. DesoukyH.M. GhaziY.A. HammamA.M. 82007108Female Baladi goats were used for investigating the toxicological effects of dioxin. Each animal in the treated group was given an oral dose of 4 mL of stock standard solution of dioxin (labelled and native congeners) diluted in 5 mL distilled water (1/3 of LD50) for three times with 2 days interval and slaughtered 16 days post treatment. Blood and tissue samples were taken and subjected for haemogram, biochemical and pathological studies as well as for determination of dioxin residues. Results revealed that exposure of female goats to dioxin induced anemia, leucocytopenia, neutropenia and eosinophilia with non significant increases in activities of serum ALT and AST as compared with untreated group. Meanwhile, activity of ALP and BUN concentration were significantly increased. Histopathological examination showed degenerative and necrotic changes associated with inflammatory reaction in liver and kidney, in addition to cystic glandular hyperplasia and adenomyosis in uterus. In ovarian tissue, marked decrease of preantral follicles together with cystic atretic follicle were noticed. The average percentage residues of pg WHO-TEQ values for dioxins (PCDDs and PCDFs) in liver, kidney, mammary gland, uterus and milk after oral dose were 0.013, 0.0012, 0.0012, 0.009 and 0.0012%, respectively. It was concluded that oral exposure to dioxin in female goats induced adverse effects on liver and kidney. Dioxins had estrogenic like effect as indicated by uterine and ovarian histopathological changes.]]>Benedict, J.C., T.M. Lin, I.K. Loeffler, R.E. Peterson and J.A. Flaws,200056382388Birnbaum, L.S.,1994102157167Brewster, D.W., D.W. Bombick and F. Matsumura,198825495507Buchanan, D.L., T. Sato, R.E. Peterson and P.S. Cooke,200057302311Chang, H., Y.J. Wang, L.W. Chang and P.A. Lin,20056815671579Frazier, D.E., A.E. Silverstone and T.A. Gasiewicz,19944720392048Funseth, E. and N.G. Ilback,199260247256Furst, P., C. Furst, H. Albert Meemken and W. Groebel,19891989Gorski, J.R., L.W. Weber and K. Rozman,1988de novo fatty acid synthesis in 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-treated rats.]]>62146151Grova, N., C. Feidt, C. Laurent and G. Rychen,200213 polycyclic aromatic hydrocarbons.]]>1210251031Heimler, I., A.L. Trewin, C.L. Chaffin, R.G. Rawlins and R.J. Hutz,1998126973Henry, R.J.,1964pp: 181-747pp: 181-747Husdan, H.,196814222222Jain, N.C.,20005th Edn.,Kind, P.R. and E.G. King,19547322322Kociba, R.I., D.G. Keyes and J.E. Beyer,197846279303Laiosa, M.D., Z.W. Lai, T.S. Thurmond, N.C. Fiore and C. DeRossi et al.,200269117124Li, B., H.Y. Liu, L.J. Dai, J.C. Lu, Z.M. Yang and L. Huang,200621301306Li, X.L., D.C. Johnson and K. Rozman,1995133321327Moran, F.M., R. Tarara, J. Chen, S. Santos, A. Cheney, J.W. Overstreet and B.L. Lasley,2001M. fascicularis).]]>15377383Murante, F.G. and T.A. Gasiewicz,200054374383Ohtake, F., K. Takeyama, T. Matsumoto, H. Kitagawa and Y. Yamamoto et al.,2003423545550Patterson, R.M., R. Stachlewitz and D. Germolec,2003190120134Patton, J. and S.R. Crouch,197749464464Payne, J.M. and S. Payne,1987Peterson, R.E., M.H. Theobald and G.L. Kimmel,199323283285Pohjanvirta, R. and J. Tuomisto,199446483549Prange, J.A., C. Gaus, R. Weber, O. Papke and J.F. Muller,20033743254329Rainer, M.,20022002Reitman, S. and S. Frankel,1957285663Rier S.E., D.C. Martin, R.E. Bowman, W.P. Dmowski and J.L. Becker,1993Macaca mulatta) following chronic exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin.]]>21433441Rier, S. and W.G. Foster,200270161170Sakai, R., T. Kajiume, H. Inoue, R. Kanno, M. Miyazaki, Y. Ninomiya and M. Kanno,2003728491Schiller, C.M., C.M. Adcock, R.A. Moore, and R.Walden,198581356361Scialli, A.R.,200115231238Snedecor, G.W. and W.G. Cochran,19807th Edn.,Pages: 507Pages: 507Son, D.S., K. Ushinohama, X. Gao, C.C. Taylor, K.F. Roby, K.K. Rozman and P.F. Terranova,1999vitro.]]>13521530Stahl, B.U. and K. Rozman,1990106158162Stanton, B.J., S.M. Watkins, J.B. German and B.L. Lasley,2002lus domesticus).]]>132129142Swift, L.L., T.A. Gasiewicz, G.D. Dunn, P.D. Soule and R.A. Neal,198159489499Tsutsumi, O., H. Uechi, H. Sone, J. Yonemoto and Y. Takai et al.,1998250498501Vajda, A.M. and D.O. Norris,2005Ambystoma tigrinum).]]>141111Vernon, M. and E.Wilson,198544684694Viluksela, M., B.U. Stahl, L.S. Birnbaum, K.W. Schramm, A. Kettrup and K.K. Rozman,19981515769Wilson, C.L. and S. Safe,199826657671Wormley, D.D., A. Ramesh and D.B. Hood,20041974965El-Sabeawy, F., E. Enan and B. Lasley,2001129317327Esser, C., S. Steinwachs, C. Herder, M. Majora and Z.W. Lai,20051578998Elsenhans, B., W. Forth and E. Richter,199165429432Cummings, A.M. and J.L. Metcalf,19959233238Fouzy, A.S.M. and U. Rouff,200658515Bancroft, J., A. Stevens and D. Turner,19964th Edn.,Pages: 740Pages: 740Franczak, A., A. Nynca, K.E. Valdez, K.M. Mizinga and B.K. Petroff,200674125130Siedel, J., E.O. Hagele, J. Ziegenhorn and A.W. Wahlefeld,19832910751080