Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2006.1004.1008RashidUmer BhattiHaq NawazHanifMuhammad AsifAhmadNajum Rasheed6200696Urinary excretion of Salicyluric acid (SUA) was investigated in twelve healthy male volunteers. Urine sample was collected up to 10 h. The concentration of salicyluric acid (SUA) a major metabolite of aspirin was measured colorimetrically. The concentration of salicyluric acid (SUA) (mean±SE) in urine was 200.5±14.9 μg mL-1. Excretion of salicyluric acid was extremely variable and depends upon pH of urine. The results show that the mean±SE values for pH of the urine was 6.24±0.11, amount of drug excreted as salicyluric acid was 63.5±12 mg and percentage of dose excreted was 10.66±1.98. The cumulative amount of dose excreted as salicyluric acid was 191.3±58.2 mg and cumulative percent of dose excreted as salicyluric acid was 62.45±1.06. There is statistically slight variation in urinary excretion of SUA data when compared with foreign investigated values.]]>Deliargyris, E.N. and H. Boudoulas,20044515Done, A.K.,196026800807Farid, N.A., G.S. Born, W.V. Kessler, S.M. Shaw and W.E. Lange,19752111671168Glasgow, J.F.T.,19991454115125Hanif, M.A., H.N. Bhatti, S. Ahmad, K. Rehman, U. Rashid, S. Amin and M.W. Sarwar,200416367Hartwig-Otto, H.,1983753037Hutt, A.J., J. Caldwell and R.L. Smith,198616239249Hutt, A.J., J. Caldwell and R.L. Smith,198212601610IARC,1997Vol. 1,pp: 1-202pp: 1-202Loll, P.J., D. Picot and R.M. Garavito,19952 synthase.]]>2637643Montgomery, P.R. and D.S. Sitar,198672125Muhammad, F.,2000Nawaz, M.,19942571212Nawaz, M., T. Iqbal and R. Nawaz,19882260260Paterson, J.R. and J.R. Lawrence,200194445448Punnon, K. and U. Pekka,198415177185Raymond, N.D.,200429124882489Reynolds, J.E., F.K. Parfitt, A.U. Parson and S.C. Sweetman,1989pp: 32pp: 32Simon, P.M. and S.J. Mills,1980252948Terry, M.B., M.D. Gammon, F.F. Zhang, H. Tawfik and S.L. Teitelbaum et al.,200429124332440Mayo Clinic,20042004