Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2000.1484.1486IqbalRabis Anjum ZiaM. IqbalTahira HussainFaqir 9200039Biodisposition kinetics of levofloxacin was determined in 9 female volunteers following oral administration of 500 mg tablets. The blood samples were collected at specific time intervals. Concentration of levofloxacin in plasma was determined by microbiological assay, that was found to be 2.39 μg/ml having 1.75 SD and 75% CV values. The pharmacokinetic parameters were determined according to single compartment open model. The average absorption rate constant was 2.00 L/h while absorption half life was 0.34 hours. Average Cmax and Tmax values were 2.43 mg/L and 1.60 hours while volume of distribution was 177 L. From Tmax studies, it is concluded that absorption is delayed due to non-fasting. It is suggested that levofloxacin can be administered orally with regard to food. It was observed the elimination half life and total body clear values were 7.40 hours and 16.54 h respectively while total area under curve was found to be 30.2 h.mg/L. It is also suggested that elimination half life is not affected by the presence of absence of food.]]>Arret, D., D. Johnson and K. Amiel,197160373378Baggot, J.D.,1977Chien, S.C., A.T. Chow, J. Natarajan, R.R. Williams, F.A. Wong, M.C. Rogge and R.K. Nayak,19974115621565Chien, S.C., F.A. Wong, C.L. Fowler, S.V. Callery-D’Amico, R.R. Williams, R. Nayak and A.T. Chow,199842885888Chien, S.C., M.C. Rogge, L.G. Gisclon, C. Curtin and F. Wong et al.,19974122562260Fish, D.N. and A.T. Chow,199732101119Katzung, B.G.,19987th Edn.,Lee, L.J., B. Hafkin, I.D. Lee, J. Hoh and R. Dix,19974121962200Nawaz, M. and B.H. Shah,19851985Nawaz, M.,19942571212Rombout, F.,19871987Steel, R.G.D. and J.H. Torrie,1984Nawaz, M., T. Iqbal and R. Nawaz,19882260260