Journal of Pharmacy and Allied Health Sciences2224-2503Asian Network for Scientific Information10.3923/jpahs.2016.14.19Newbouldia laevis and Crateva adansonii]]>NdarubuTsado A. BashirLawal ChukwudiOssai P. AliyuJagaba KontagoraGwadabe N. GbokeJiya A. MuhammadUmar A. OlabodeOladunjoye J. 1-2201661-2Plants and plant products are continuously being explored in medicine against free radicals induced oxidative stress and increasing No. of antibiotic resistant organisms. In the present study antioxidants and antimicrobial activity of methanol leaf extract of N. laevis and Crateva adansonii against some pathogenic microorganism were carried out. The antioxidants activities were conducted using DPPH radical scavenging assay. The antibacterial activity was screened against Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus and E. coli using agar well diffusion method at various concentrations (160, 120 and 80 mg mL1). The Minimum Inhibitory Concentration (MIC) was determined using serial dilution method, while Minimum Bacterialcidal Concentration (MBC) by plating various dilution of extract. Results revealed the presence of alkaloid, flavonoids, saponins, terpenoids, glycoside and anthraquinone in methanol leaf extract of N. laevis. Newbouldia laevis and Crateva adansonii extracts and the standard antioxidant (Vitamin E) promoted an inhibition of DPPH radical with increasing concentrations. The IC50 values of C. adansonii, N. laevis and Vitamin E were 1562.52, 155.17 and 83.65 mg mL1, respectively. The zone of inhibition demonstrated by the two extracts increase with increase concentration. The MIC of both extracts was in range of 120-160 mg mL1, while the MBC range between 120-160 mg mL1. It is concluded that N. laevis contains some useful phytochemicals with potential antioxidants and antibiotic reputations. Thus, it may be considered as a natural source of antimicrobials and antioxidants for therapeutic purposes.]]>WHO.,20102010Lawal, B., O.K. Shittu, A.Y. Kabiru, A.A. Jigam, M.B. Umar, E.B. Berinyuy and B.U. Alozieuwa,2015Potential antimalarials from African natural products: A reviw.]]>4318343Bashir, L., O.K. Shittu, S. Sani, M.B. Busari and K.A. Adeniyi,201574579Mohammed, A., M.A. Ibrahim and M.H. Islam,201480354377Lawal, B., O.K. Shittu, A.N. Abubakar, I.Z. Olalekan, A.M. Jimoh and A.K. Abdulazeez,2016Apis mellifera) propolis.]]>54348Lawal, B., O.K. Shittu, T. AbdulRasheed-Adeleke, P.C. Ossai and A.M. Ibrahim,2015Archachatina maginata) haemolymph.]]>105964Yusuf, O.K. and C.O. Bewaji,2011Allium sativum extract on Trypanosoma brucei infected rats.]]>31721Lawal, B., O.K. Shittu, P.C. Ossai, A.N. Abubakar and A.M. Ibrahim,2015Achachatina maginata) haemolymph in CCl4-induced hepatotoxixity in albino rats.]]>6141154Badarinath, A.V., K.M. Rao, C.M.S. Chetty, S. Ramkanth, T.V.S. Rajan and K. Gnanaprakash,2010in-vitro antioxidant methods: Comparisons, correlations and considerations.]]>212761285Tsado, A.N., L. Bashir, S.S. Mohammed, I.O. Famous, A.M. Yahaya, M. Shu'aibu and T. Caleb,2015Crateva adansonii in Plasmodium berghei infected mice.]]>6165173Tsado, A.N., L. Bashir, S.E. Saba, M.A. Saba, B.M. Mohammed, I.H. Abdulsalam and G.J. Josiah,2015Crateva adansonii leaves in Swiss albino rats.]]>10173179Le Grand, A.,198925315338, (In French)Iwu, M.M., A.R. Duncan and C.O. Okunji,19991999pp: 457-462pp: 457-462Sofowora, A.,19962365372Lawal, B., P.C. Ossai, O.K. Shittu and A.N. Abubakar,201462137Jayaraman, S., M.S. Manoharan and S. Illanchezian,2008In-vitro antimicrobial and antitumor activities of Stevia rebaudiana (Asteraceae) leaf extracts.]]>711431149Trease, G.E. and W.C. Evans,198911th Edn.,pp: 48-65pp: 48-65Singh, B., T.K. Bhat and B. Singh,20035155795597Kumar, N., K.K.M. Ahmad, R. Dang and A. Husain,20082361364Shahidi, F.,200044158163Taiwo, O., H.X. Xu and S.F. Lee,199913675679Muruhan, S., S. Selvaraj and P.K. Viswanathan,2013In vitro antioxidant activities of Solanum surattense leaf extract.]]>32834Saha, M.R., M.A. Alam, R. Akter and R. Jahangir,2008In vitro free radical scavenging activity of Ixora coccinea L.]]>39096Ara, N. and H. Nur,2009In vitro antioxidant activity of methanolic leaves and flowers extracts of Lippia alba.]]>4107110