Journal of Pharmacy and Allied Health Sciences2224-2503Asian Network for Scientific Information10.3923/jpahs.2016.1.7Plasmodium berghei Infected Swiss Mice Treated with some Plant Extracts]]>UrakuA.J. 1-2201661-2Hepatoprotective effects of ethanol leaf extract of Spilanthes uliginosa, Ocimum basilicum, Hyptis spicigera and Cymbopogon citratus against Plasmodium berghei induced malaria in Swiss mice were investigated. Eighty four swiss mice of both sexes were used. All the mice were infected intraperitoneally with 0.2 mL parasitized blood suspension and parasitemia assessed by Giemsa stain thin blood films after three days (72 h). The mice were divided into 6 groups namely; A, B, C, D, E and F. Groups B, C, D and E were subdivided into three: B1, B2, B3, C1, C2, C3, D1, D2, D3, E1, E2 and E3. Both groups and subgroups contained six mice each. The subgroups were treated with the extracts of Spilanthes uliginosa (Sw), Ocimum basilicum, Hyptis spicigera and Cymbopogon citratus each for five consecutive days with 200, 400 and 800 mg kg1 b.wt., via oral intubation once daily. The results indicated a general significant (p<0.05) decrease in the average body weight of the parasitized untreated mice and a dose dependent significant reductions (p<0.05) in the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in parasitized treated mice. Dose dependent significant elevations (p<0.05) were observed in total protein and albumin concentrations of parasitized treated mice. The results suggest that these plants possess hepatoprotective potential.]]>Alisi, C.S., G.O.C. Onyeze, O.A. Ojiako and C.G. Osuagwu,2011Chromolaena odorata Linn. extract on carbon tetrachloride-induced oxidative liver damage.]]>16981Guyton, A.C. and J.E. Hall,200217th Edn.,pp: 233-236pp: 233-236Raimi, M.M., A.M. Oyekanmi and B.M. Adegoke,2014Sida acuta.]]>79398Uraku, A.J. and M.E. Ogbanshi,2015Spilanthes uliginosa (Sw) leaves.]]>3111119Mir, M.A., S.S. Sawhney and M.M.S. Jassal,2013Taraxacum officinale.]]>215Mgbemena, I.C., F.N. Opara, A. Ukaoma, C. Ofodu, I. Njoku and D.H. Ogbuagu,20106503507Uraku, A.J.,2014Spilanthes uliginosa (Sw), Ocimum basilicum, Hyptis spicigera and Cymbopogon citrates leaf extracts on biochemical and histological parameters of mice exposed to Plasmodium berghei.]]>2014Tripathi, K.D.,20137th Edn.,pp: 816-835pp: 816-835Uraku, A.J., A.N.C. Okaka, U.A. Ibiam, K.N. Agbafor and N.A. Obasi et al.,2015Spilanthes uliginosa, Ocimum basilicum (Sweet Basil), Hyptis spicigera and Cymbopogon citrates on mice exposed to Plasmodium berghei Nk 65.]]>62836Deutsche, G.K.C.,197210182182Reitman, S. and S. Frankel,1957285663Tietz, I.,2000pp: 68-134pp: 68-134Haruna, Y., H.O. Kwanashie, J.A. Anuka, S.E. Atawodi and I.M. Hussaimi,2013In-vivo anti-malarial activity of methanol root extract of Securidaca longepedunculata in mice infected with Plasmodium berghei.]]>3716Iyawe, H.O.T. and A.O. Onigbinde,2010Plasmodium berghei infection and folic acid treatment on biochemical and antioxidant indicators in mice.]]>81821Olorunnisola, O.S. and A.J. Afolayan,2011In vivo anti-malaria activity of methanolic leaf and root extracts of Sphenocentrum jollyanum pierre.]]>516691673Patrick-Iwuanyanwu, K.C., C.C. Onyemaenu, M.O. Wegwu and E.O. Ayalogu,201154957Fabbri, C., R. de Cassia Mascarenhas-Netto, P. Lalwani, G.C. Melo and B.M.L. Magalhaes et al.,2013Plasmodium vivax malaria patients evolving with cholestatic jaundice.]]>2013George, B.O., E. Osioma, J. Okpoghono and O.O. Aina,2011Plasmodium berghei infected mice treated with aqueous extract of Aframomum sceptrum.]]>5277281Ujowundu, C.O., F.N. Kalu, C.U. Igwe, N.C. Agha and K.O. Igwe,201128797Emeka, E.J.I. and O. Obidoa,2009Gongronema latifolium Benth. on some biochemical and histological parameters in male albino rats.]]>9859865Ghebreselassie, D., Y. Mekonnen, G. Gebru, W. Ergete and K. Huruy,2011Moringa stenopetala on blood parameters and histopathology of liver and kidney in mice.]]>255157Al-Omar, I.A., A.M. Eligail, R.M. Al-Ashban and A.H. Shah,2010148389Orhue, N.E.J., E.A.C. Nwanze and A. Akafor,2005Scoparia dulcis.]]>411521155Adedapo, A.A., A.Y. Adegbayibi and B.O. Emikpe,2005Phyllanthus amarus in rats.]]>19971976