Journal of Biological Sciences1727-30481812-5719Asian Network for Scientific Information10.3923/jbs.2016.22.29AdegbiteOluwatobi Samuel Iyanda-JoelWisdom Oluwayemi AkinsanyaYetunde Ifeoma AkaBabafemi Nsikan MogboPrincessca Anulika YakubuOmolara Faith OladipoBlessing Oluwatosin AfolabiBlessing Ariyo KukoyiAyobami Jahdahunsi OmiyaleBenjamin Olusola IyohaAlex Emmacume MaduagwuEmmanuel Ndubuisi 1-22016161-2Mitochondrial Permeability Transition (MPT) is reported as the mechanism of acetaminophen induced hepatic damage, however, rat models are resistant to acetaminophen induced toxicity. The occurrence and degree of mitochondrial permeability transition after treatment with 400 mg kg1 of acetaminophen in albino Wistar rats were assessed. Animals were randomly distributed into seven groups; control, 12, 24, 36, 48, 60 and 72 h based on varying time (in hour) post acetaminophen prior to sacrifice after treatment. Mitochondrial Membrane Permeability Transition (MMPT) pore opening and mitochondrial cytochrome c release were estimated. Opening of MMPT pore and cytochrome c release were observed in 12, 24, 36 and 72 h, when compared with the control group. Liver function and histological results indicated no liver damage. It is concluded that toxic dose of acetaminophen induced mitochondrial permeability transition in rat hepatic tissues without leading to necrotic damage suggesting that rat hepatic tissues evade damage by mechanisms downstream of MPT.]]>Adebayo, A.H., O.S. Adegbite, J.A.O. Olugbuyiro, O.O. Famodu and K.B. Odenigbo,2014Olax subsorpioidea on albino Wistar rats.]]>8570578Adegbite, O.S., Y.I. Akinsanya, A.J. Kukoyi, W.O. Iyanda-Joel, O.O. Daniel and A.H. Adebayo,2015Olax subscorpioidea.]]>7S63S68Ahmed, M.H. and C.D. Byrne,20101642434252Alano, C.C., G. Beutner, R.T. Dirksen, R.A. Gross and S.S. Sheu,200280531538Bernal, W.,200323227237Bessems, J.G.M. and N.P.E. Vermeulen,20013155138Chen, C., K.W. Krausz, J.R. Idle and F.J. Gonzalez,200828345434559Connern, C.P. and A.P. Halestrap,1994302321324Cover, C., A. Mansouri, T.R. Knight, M.L. Bajt, J.J. Lemasters, D. Pessayre and H. Jaeschke,2005315879887Davidson, D.G. and W.N. Eastham,19662497499Elmore, S.,200735495516Gao, W., Y. Pu, K.Q. Luo and D.C. Chang,200111428552862Green, D.R. and J.C. Reed,199828113091312Iyanda-Joel, W., O. Adegbite, O. Ajetunmobi, S. Chinedu, E. Iweala and S. Rotimi,2015Annona muricata Linn. (Soursop).]]>238S248S248Jaeschke, H., M.R. McGill and A. Ramachandran,20124488106Kinnally, K.W. and B. Antonsson,200712857868Knockaert, L., V. Descatoire, N. Vadrot, B. Fromenty and M.A. Robin,201125475484Kon, K., J.S. Kim, H. Jaeschke and J.J. Lemasters,20044011701179Kon, K., K. Ikejima, K. Okumura, T. Aoyama and K. Arai et al.,200722S49S52Lapidus, R.G. and P.M. Sokolove,1993306246253Larson, A.M., J. Polson, R.J. Fontana, T.J. Davern and E. Lalani et al.,20054213641372Li, L.Y., X. Luo and X. Wang,20014129599Li, Y.Z., C.J. Li, A.V. Pinto and A.B. Pardee,19995232239Lowry, O.H., N.J. Rosebrough, A.L. Farr and R.J. Randall,1951193265275Masubuchi, Y., C. Suda and T. Horie,200542110116McGill, M.R., C.D. Williams, Y. Xie, A. Ramachandran and H. Jaeschke,2012264387394NIH.,1985NIH Publication No. 85-123,Bababunmi, E.A., O.O. Olorunsogo and O. Bassir,1979N-(phosphonomethyl) glycine on isolated rat liver mitochondria.]]>28925927Ow, Y.L.P., D.R. Green, Z. Hao and T.W. Mak,2008c: Functions beyond respiration.]]>9532542Qu, X. and L. Qing,200437445453Reid, A.B., R.C. Kurten, S.S. McCullough, R.W. Brock and J.A. Hinson,2005312509516Rodriguez-Enriquez, S., L. He and J.J. Lemasters,20043624632472Soeda, J., S. Miyagawa, K. Sano, J. Masumoto, S. Taniguchi and S. Kawasaki,2001c release into cytosol with subsequent caspase activation during warm ischemia in rat liver.]]>281G1115G1123Verhagen, A.M., P.G. Ekert, M. Pakusch, J. Silke and L.M. Connolly et al.,20001024353Wang, K. and B. Lin,20132013Shen, H.M. and S. Pervaiz,20062015891598