Journal of Applied Sciences1812-56541812-5662Asian Network for Scientific Information10.3923/jas.2017.407.414Ficus capensis Stem Bark Protects Against Changes in Biomarker Levels of Carbontetrachloride-induced Cardiotoxicity of Rats]]>NjokuUgochi Olivia OgugoforMartins Obinna NwodoOkwesili Fred Chiletugo 82017178Background and Objective: Ficus capensis is one of the plants used in folklore medicine in Nigeria, for the treatment of various disease conditions and promotion of vascular health. This study was undertaken to investigate its cardioprotective potential against carbontetrachloride (CCl4)-induced myocardial necrosis in rats. Materials and Methods:Albino rats were divided into four main groups: normal control, CCl4 control, 1.2 mg kg1 b.wt., aspirin pre-treated and Ficus capensis extract pre-treated groups. Extract was administered orally at doses of 100, 200, 300 and 400 mg kg1 b.wt., for 7 days to evaluate their effect on CCl4-induced cardiotoxicity. Aspirin was used as standard drug. On day 7, cardiotoxicity was induced in animals of CCl4 control, aspirin and extract pre-treatment groups. Histopathological examination was performed to evaluate the basic action of extract and statistical differences were assessed using one-way ANOVA and Duncan's multiple range test with SPSS version 22.0. Results: CCl4 intoxication in CCl4 treated rats caused significant (p<0.05) increases in serum contents of cardiac biomarker enzymes and raise in lipid peroxidation whereas significant (p<0.05) decreases in cardiac enzymatic antioxidant and glutathione reductase contents were observed when compared to normal control. Pre-treatment with Ficus capensis stem bark extract expressed cardioprotective ability against CCl4-induced oxidative changes in myocardium by significantly (p<0.05) altering levels of cardiac biomarker enzymes towards normal, enhancing the activity of suppressed antioxidant enzymes and lessening lipid peroxidation level. Histopathological examination of cardiac tissues, following extract pre-treatment showed correlation with serological studies. Conclusion: Based on these findings, Ficus capensis stem bark is potent against CCl4-induced oxidative stress in heart due to its antioxidant and cell stabilization property.]]>Al-Sowayan, N.S. and N.H. Mahmoud,2014510781089Ojha, S., J. Bhatia, S. Arora, M. Golechha, S. Kumari and D.S. Arya,2011Commiphora mukul against isoprenaline-induced cardiotoxicity: A biochemical and histopathological evaluation.]]>32731738Rai, S.S., B. Somashekar and K.P.S. Gowda,2015Ipomoea batatas on doxorubicin induced cardiotoxicity in rats.]]>8444450Ozturk, F., M. Ucar, I.C. Ozturk, N. Vardi and K. Batcioglu,200362353356Upur, H., N. Amat, B. Blazekovi, A. Talip,2009Cichorium glandulosum root extract on carbon tetrachloride-induced and galactosamine-induced hepatotoxicity in mice.]]>4720222030Adewole, S.O., A.A. Salako, O.W. Doherty and T. Naicker,200710153164Khan, R.A., M.R. Khan and S. Sahreen,2012Sonchus asper against KBrO3 induced lipid peroxidation in rats.]]>2012Turkdogan, M.K., Z. Agaoglu, Z. Yener, R. Sekeroglu, H.A. Akkan and M.E. Avci,2001Nigella sativa in the prevention of liver fibrosis and cirrhosis in rabbits: New hopes.]]>1087173Otitoju, G.T.O., J.U. Nwamarah, O. Otitoju, E.C. Odoh and L.U. Iyeghe,20144208217Umeokoli, B.O., F.A. Onyegbule, T.H. Gugu and S.O. Igboeme,2013Ficus capensis leaf extract in the treatment of anaemia.]]>2013Ramde-Tiendrebeogo, A., A. Tibiri, A. Hilou, M. Lompo, H. Millogo-Kone, O.G. Nacoulma and I.P. Guissou,2012Ficus sur Forssk. and Ficus sycomorus L. (Moraceae): Potential for sickle cell disease treatment in Burkina Faso.]]>6328336Owolabi, O.J., Z.A. Nworgu, A. Falodun, B.A. Ayinde and C.N. Nwako,2009Ficus capensis Thunb. (Moraceae).]]>66293296Daikwo, O.A., J.A. Tende, S.M. Okey, E.D. Eze and A.S. Isa,2012Ficus capensis Thunb (Moraceae) on in vivo leukocyte mobilization in wistar rats.]]>3110114Gelfand, M., S. Mavi, R.B. Drummond and B. Ndemera,1985Pages: 411Pages: 411Harborne, J.B.,19733rd Edn.,Pages: 279Pages: 279Trease, G.E. and W.C. Evans,200215th Edn.,pp: 2, 42-44, 221-229, 246-249, 304-306, 331-332, 391-393pp: 2, 42-44, 221-229, 246-249, 304-306, 331-332, 391-393Harborne, J.B.,19983rd Edn.,Pages: 271Pages: 271Soni, A. and S. Sosa,201322229Agbafor, K.N., C. Ezeali, E.I. Akubugwo, I.K. Obiudu and A.J. Uraku et al.,2015Newbouldia laevis against carbon tetrachloride induced-cardiotoxicity in albino rats.]]>917Wallin, B., B. Rosengren, H.G. Shertzer and G. Camejo,19932081015Fridovich, I.,198926477617764Aebi, H.E.,19831983pp: 273-286pp: 273-286Goldberg, D.M. and R.J. Spooner,19831983pp: 258-265pp: 258-265AOAC.,199014th Edn.,pp: 503-515pp: 503-515Pearson, D.,197617th Edn.,pp: 3-4pp: 3-4Drury, R.A.B., E.A. Wallington and R. Cameron,19674th Edn.,pp: 279-280pp: 279-280Mahajan, B.K.,19971997pp: 130-155pp: 130-155Uzoekwe, N.M. and J.J. Mohammed,2015Ficus capensis.]]>19633637Sahreen, S., M.R. Khan, R.A. Khan and H.M. Alkreathy,20144 induced toxicity in rats.]]>2014Saravanan, G., P. Ponmurugan, M. Sathiyavathi, S. Vadivukkarasi and S. Sengottuvelu,2013Amaranthus viridis Linn: Effect on serum marker enzymes, cardiac troponin and antioxidant system in experimental myocardial infarcted rats.]]>165494498Denwick, P.M.,20022nd Edn.,pp: 241-243pp: 241-243Papp, L.V., J. Lu, A. Holmgren and K.K. Khanna,20079775806Suresh, B., J.K. Shetty and M. Prakash,2010434253429Boumerfeg, S., A. Baghiani, D. Messaoudi, S. Khennouf and L. Arrar,2009Tamus communis L. root extracts.]]>23283288Soetan, K.O.,2008747134721Jimoh, F.O., S.A. Babalola and M.T. Yakubu,2009Cnidoscolous chayamansa.]]>47903909