International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2018.271.275Premna pubescens. Blume and Centella asiatica Extracts Against Bacteria and Fungi Pathogens]]>RestuatiMartina DiningratDiky Setya 22018142Background and Objective: North Sumatera Indonesia has a rich heritage of knowledge on medicinal plants used for preventive and curative medicine Premna pubescens. Blume (Buasbuas) has been used to increase the body immunity and endurance. Centella asiatica (Pegagan) is used for medicinal purposes. This study is important to find out the antimicrobial capabilities of Premna pubescens (P. pubescens) and Centella asiatica (C. asiatica) methanol extracts. This study is expected to provide the scientific foundation for the development of plants that are traditionally believed to be efficacious drug. The aim of the study was to investigate in vitro antimicrobial activity of North Sumatera medicinal plants P. pubescens and C. asiatica against the main pathogens. Materials and Methods: The organic solvent plant extracts are tested on the various microorganisms including bacteria and fungi by using agar diffusion technique. The data was analyzed with ANOVA statistics by using SPSS software. Results: The length of the inhibition zone was measured in mm from the edge of the well to the inhibition zone. P. pubescens showed significant moderate activity against (14 mm) Pseudomonas marginalis and (21 mm) Streptococcus mutans with 100 mg mL1 DMSO plant drug concentration. The results of lowest (MICs) values are at 66 and highest ones are at 152 mg mL1 for P. pubescens meanwhile those of (MICs) values are 0-155 mg mL1 for C. asiatica. Conclusion: In general, based on the result of this research, it can be said that P. pubescens and C. asiatica plants can be used as antibacterial and antifungal compounds.]]>Santajit, S. and N. Indrawattana,20162016Suswardany, D.L., D.W. Sibbritt, S. Supardi, J.F. Pardosi, S. Chang and J. Adams,20172017Khairiah, A., Nisyawati and M. Silalahi,20172017Villalobos, M.D.C., M.J. Serradilla, A. Martin, E. Ordiales, S. Ruiz-Moyano and M.D.G. Cordoba,20169621162124Diningrat, D.S., S.M. Widiyanto, A. Pancoro, A. Iriawati and D. Shim et al.,2015Tectona grandis, L.F) in vegetative to generative stages development.]]>10114Restuati, M., U. Hidayat, A.S.S. Pulungan, N. Pratiwi and D.S. Diningrat,2016Premna pubescens Blume) leaf extracts against Bacillus cereus and Escherichia coli.]]>118185Diningrat, D.S., S.M. Widiyanto, A. Pancoro, Iriawati and D. Shim et al.,2015Tectona grandis) floral development regulation using RNA-seq.]]>10113Lin, J., H. Jiang and X. Ding,2017282327Manaf, S.R., M.D. Hassan, M.M. Noordin, A.A. Razak and R.H. Hayati et al.,2017Oreochromis sp.).]]>2017pp: 540548Micheloud, J.F., L.A. Colque-Caro, L.R. Comini, J.L. Cabrera, S. Nunez-Montoya, O.G. Martinez and E.J. Gimeno,2017Heterophyllaea pustulata Hook. f. (Rubiaceae), in sheep from Northwestern Argentina.]]>4915531556Perwitasari, D.A., N. Mahdi, M. Muthaharah and I.N. Kertia,2016135760Leeratiwong, C., P. Chantaranothai and A. Paton,2016Premna L. (Lamiaceae) in Thailand.]]>44122124Khotimah, S.N. and A. Muhtadi,20172017Bezerra, C.F., E.F. Mota, A.C.M. Silva, A.R. Tome and M.Z.R. Silva et al.,2017Calotropis procera: Toxicity and immunological tolerance revisited.]]>274138149Balouiri, M., M. Sadiki and S.K. Ibnsouda,2016in vitro evaluating antimicrobial activity: A review.]]>67179Wibowo, M.A. and V.V. Harlia,2016Premna serratifolia Linn).]]>2016Tan, Y., D. Li, Y. Chen and B. Li,2017Premna bhamoensis (Lamiaceae, Premnoideae), a new species from Kachin state, Northeastern Myanmar.]]>8393101Wen, X., J. Hempel, R.M. Schweiggert, Y. Ni and R. Carle,2017Physalis alkekengi L. and P. pubescens L.) fruits and calyces.]]>6561406151Phillips, C.J., N.A. Wells, M. Martinello, S. Smith, R.J. Woodman and D.L. Gordon,2016Staphylococcus aureus with elevated vancomycin minimum inhibitory concentrations within the susceptible range.]]>98792Lam, K.Y., A.P.K. Ling, R.Y. Koh, Y.P. Wong and Y.H. Say,20162016Miyazaki, Y., K. Nakajima, M. Hosaka, N. Ban and T. Takahashi et al.,201626943949Jayaprakash, S.B. and N. Nagarajan,2016Centella asiatica (Linn).]]>4181185