International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2017.501.506Quercus dilatata Fruit: A Randomized Control Trial]]>ShaheenMusarat Ali KhanRahmat AhmedMushtaq MushtaqNadia KhanNisar 52017135Background and Objective: Quercus dilatata is traditionally used for the treatment of various human diseases. The present study was conducted for the determination of in vivo anti-diabetic activity and diabetes complications preventive effect of the Quercus dilatata. Methodology: The methanol extract of Quercus dilatata (200 and 400 mg kg1; orally) was administered in alloxan induced (150 mg kg1; intraperitoneally) diabetic rats. Glibenclamide (10 mg kg1 day1 orally) was used as a standard drug. Diabetic rats boosted the levels of blood glucose, serum lipids (triglycerides, cholesterol, low density lipoprotein and serum high density lipoprotein levels), liver enzymes (serum alanine transaminase (ALT), alkaline phosphatase (ALP) and total bilirubin), serum urea, creatinine and total protein. Results: After 21 days of treatment, the plant extract at a dose of 200 and 400 mg kg1 day1 significantly reduced the elevated blood glucose level in diabetic rats by 114.975 and 111.520%, respectively. Extracts of Quercus dilatata (both doses) proved to have anti-diabetic activity by decreasing the elevated level of plasma blood glucose, with subsequent increase in body weight. Extracts of Quercus dilatata (both doses) also proved to have lipids, hepatic and renal protective activity by reducing the elevated level of enzymes and other biochemical markers. Extract at a dose of 200 mg kg1 revealed highly significant (p<0.05)results as compared to 400 mg kg1 dose. Conclusion: On the basis of the results it is concluded that Quercus dilatata extract can be used to treat diabetes, kidney and liver disorders and serum lipids related abnormality.]]>Ahlem, S., H. Khaled, M. Wafa, B. Sofiane, D. Mohamed, M. Jean-Claude and E.F. Abdelfattah,2009Eucalyptus globulus extract reduces the alloxan-induced oxidative stress in rats.]]>1817176Barthelson, R.A., P. Sundareshan, D.W. Galbraith and R.L. Woosley,200693566574Ahmed, A.B.A., A.S. Rao and M.V. Rao,2010In vitro callus and in vivo leaf extract of Gymnema sylvestre stimulate β-cells regeneration and anti-diabetic activity in Wistar rats.]]>1710331039Saxena, A. and N.K. Vikram,200410369378Saxena, A.M., S.K. Mukherjee and G. Shukla,2006pp: 104pp: 104Gupta, R., K.G. Bajpai, S. Johri and A.M. Saxena,20085117Mukherjee, P.K., K. Maiti, K. Mukherjee and P.J. Houghton,2006106128Aliu, A.Y. and N. Nwude,19821st Edn.,pp: 104-110pp: 104-110Pant, M.C. and S. Govind,1998Trichosanthes dioica (Roxb).]]>87398400Annida, B. and P.S.M. Prince,20058382385Ragavan, B. and S. Krishnakumari,2006T. arjuna bark extract in alloxan induced diabetic rats.]]>21123128Kumar, A., R. Ilavarasan, T. Jayachandran, M. Deecaraman, P. Aravindan, N. Padmanabhan and M.R.V. Krishan,2008Syzygium cumini and its isolated compound against streptozotocin-induced diabetic rats.]]>2246249Tanko, Y., A.H. Yaro, A.I. Isa, M. Yerima, M.I.A. Saleh and A. Mohammed,2007Cissampelos mucronata (Menispermaceae) on blood glucose levels of streptozocin-induced diabetic Wistar rats.]]>1113116Bondy, P.K., W.L. Bloom, V.S. Whitner and B.W. Farrar,19492811261133Felig, P., E. Marliss, J.L. Ohman and C.F. Cahill Jr.,197019727728Khan, M.R., W. Rizvi, G.N. Khan, R.A. Khan and S. Shaheen,2009Digera muricata.]]>1229199Srinivasan, M., R. Rukkumani, A.R. Sudheer and V.P. Menon,200519491496Dalle-Donne, I., R. Rossi, R. Colombo, D. Giustarini and A. Milzani,200652601623Doi, K., S. Kurabe, N. Shimazu and M. Inagaki,19914-induced hepatic cirrhosis.]]>252125Georg, P. and B. Ludvik,20003159162Khan, R.A.,2017Sonchus asper Hill.]]>2017