International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2017.1047.1054Dregea sinensis Hemsl. (Daibaijie) Against Aspirin-induced Gastric Ulcers in Rats]]>SuheryaniImran LiYujuan DaiRongji LiuXiujie AnwerShoaib JuanSong DengYulin 82017138Background and Objective: Daibaijie (DBJ) is Chinese name of Dregea sinensis Hemsl. Traditionally it is used for treatment of various diseases. The objective of study was to determine the gastroprotective effect of DBJ against aspirin-induced gastric ulcers. Methodology: In this research 60 Sprague Dawley (SD) rats were divided into 6 groups. Water was provided to normal and negative groups, omeprazole (20 mg kg1) to positive group and DBJ extract (1, 2 and 3 g kg1) to low, middle and high dose groups, respectively as pre-treatment. After 1 h of pre-treatment, aspirin (250 mg kg1) were administered to all groups except normal group. Above scheduled treatments were provided continuously for 2 weeks. After 2 weeks, rats were sacrificed. The pH plus acidity, Gastric Wall Mucus (GWM), ulcer index, histological assessment, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), malondialdehyde (MDA), myeloperoxidase (MPO), prostaglandin E2 (PGE2) and protein concentration were examined. Moreover, all the data were statistically analyzed by one way ANOVA, followed by students t-test to compare different groups. Results: The DBJ showed a dose-dependent (60.11-84.34%) protection, while omeprazole showed (82.74%) protection. In addition, DBJ also considerably increased (p<0.01) the pH and reduced the acidity of gastric contents. Gastric levels of antioxidant enzymes SOD, CAT, GSH-Px were markedly enhanced while MDA level and MPO activity significantly reduced (p<0.001) by DBJ. Furthermore, DBJ also increased the PGE2 level and mucus production. Conclusion: It is concluded from results, that DBJ extract has great potential to prevent stomach ulcers. The gastroprotective effect might be associated to increase in PGE2 to produce mucus and inhibition of neutrophil infiltration due to decrease in MPO activity.]]>Brown, L.F. and D.E. Wilson,1999253038Dimaline, R. and A. Varro,200792591601Zapata-Colindres, J.C., S. Zepeda-Gomez, A. Montano-Loza, E. Vazquez-Ballesteros, J.D.J. Villalobos and F. Valdovinos-Andraca,2006Helicobacter pylori infection and nonsteroidal anti-inflammatory drugs in peptic ulcer disease.]]>20277280Allen, A. and A. Garner,198021249262Laine, L., K. Takeuchi and A. Tarnawski,20081354160Rang, H.P., M.M. Dale, J.M. Ritter, R.J. Flower and G. Henderson,20127th Edn.Pohle, T., T. Brzozowski, J.C. Becker, I.R. van der Voort and A. Markmann et al.,200115677687Gupta, L.M. and R. Raina,199875897900Hosbach, I., G. Neeb, S. Hager, S. Kirchhoff and B. Kirschbaum,200358282283Committee of Flora of China,2010Vol. 63.Pages: 496Pages: 496Committee of Chinese Materia Medica,1999Vol. 6.Pages: 358Pages: 358Lin, F.K., J.W. Fu, J. Liu, R.P. Hou and B.W. Yu,2015352933Kanter, M., H. Demir, C. Karakaya and H. Ozbek,2005Nigella sativa L oil and its constituent, thymoquinone against acute alcohol-induced gastric mucosal injury in rats.]]>1166626666Srivastava, V., A.H.M. Viswanathaswamy and G. Mohan,201042185188Corne, S.J., S.M. Morrissey and R.J. Woods,1974242116117Li, W.F., D.J. Hao, T. Fan, H.M. Huang, H. Yao and X.F. Niu,20142081827Bradford, M.M.,197672248254Antonisamy, P., P. Kannan, A. Aravinthan, V. Duraipandiyan and M. Valan Arasu et al.,2014Chromobacterium violaceum on indomethacin-induced gastric lesions in rats: Investigation of potential mechanisms of action.]]>2014Jain, K.S., A.K. Shah, J. Bariwal, S.M. Shelke, A.P. Kale, J.R. Jagtap and A.V. Bhosale,20071511811205Zakaria, Z.A., T. Balan, V. Suppaiah, S. Ahmad and F. Jamaludin,2014Muntingia calabura.]]>15111841193Rachchh, M.A. and S.M. Jain,2008Benincasa hispida fruit extract.]]>40271275Adhikary, B., S.K. Yadav, K. Roy, S.K. Bandyopadhyay and S. Chattopadhyay,20102010Liu, Y.H., Z.B. Zhang, Y.F. Zheng, H.M. Chen and X.T. Yu et al.,201526384391Jainu, M., K.V. Mohan and C.S.S. Devi, 2006Cissus quadrangularis on neutrophil mediated tissue injury induced by aspirin in rats.]]>104302305Liu, L., J. Cui, C.J. Song, J.S. Bian and A. Sparatore et al.,20122012Zhang, J.Y., Q.F. Wu, Y. Wan, S.D. Song and J. Xu et al.,20142016141622Sebai, H., M.A. Jabri, A. Souli, K. Hosni and S. Selmi et al.,2014Artemisia campestris extract against aspirin-induced gastric lesions and oxidative stress in rat.]]>44983149841Karakoyun, B., M. Yuksel, F. Ercan, C. Erzik and B.C. Yegen,2009323746Chanudom, L. and J. Tangpong,2015Syzygium cumini (L.) Skeels on indomethacin-induced acute gastric ulceration.]]>2015Yang, C., Y. Song and H. Wang,201730177186Zhang, W., K. Liu, L. Li, Y. Li and X. Sui et al.,201631813820