International Journal of Cancer Research1811-97271811-9735Academic Journals Inc.10.3923/ijcr.2017.76.83Soliman KhaterDina KasemRehab Fawzi MorsyReham Awad 22017132Background and Objective: Odontogenic tumors comprise a complex group of lesions which can pretense diagnostic challenges because of overlapping and diverse histopathologic types and clinical behaviors. An understanding of the biological behavior of these lesions is of fundamental importance for the final diagnosis and treatment planning, as these have an influence on the prognosis. The goal of the present study was to analyze and correlate the immunohistochemical expression of NF-κB and its transcription targets Bcl-xL and COX-2 in different odontogenic tumors. Materials and Methods: Thirty paraffin blocks of different odontogenic tumors (six dentigerous cyst, fourteen simple ameloblastoma, five unicystic ameloblastoma and five ameloblastic carcinoma) were selected. Immunohistochemistry was performed using the standard method (Avidin biotin peroxidase) to detect the polyclonal anti-NF-κB, Bcl-xL and COX-2 antibodies. One-way ANOVA and Spearman correlation test was used for statistical analyses. Results: The overall expression of the three antibodies (NF-κB, Bcl-xL and COX-2) increased significantly (p-value was considered significant when p<0.05) from dentigerous cyst to ameloblastoma and reached their highest values in the cases of ameloblastic carcinoma. Conclusion: The interaction between the three proteins in blocking apoptosis and increasing proliferation may constitute an important pathogenic mechanism of tumorigenesis and hence might play a role in the behavior of odontogenic tumors.]]>Khalifa, G.A., H.M. Shokier and E.A. Abo-Hager,2010226172De Andrade Santos, P.P., A.R.L. de Aquino, A.O. Barreto, R. de Almeida Freitas, H.C. Galvao and L.B. de Souza,2011112476483Henriques, A.C.G., M.G. Vasconcelos, H.C. Galvao, L.B. de Souza and R. de Almeida Freitas,2011112468475Robinson, L. and M.G. Martinez,19774022782285Ackermann, G.L., M. Altini and M. Shear,198817541546Philipsen, H.P. and P.A. Reichart,199834317325Benlyazid, A., M. Lacroix-Triki, R. Aziza, A. Gomez-Brouchet, M. Guichard and J. Sarini,2007104e17e24Van Waes, C.,20071310761082Chen, F.E. and G. Ghosh,19991868456852Pahl, H.L.,19991868536866Barkett, M. and T.D. Gilmore,19991869106924Karin, M. and A. Lin,20023221227Burstein, E. and C.S. Duckett,200315732737Chen, C., L.C. Edelstein and C. Gelinas,20002026872695Zha, S., V. Yegnasubramanian, W.G. Nelson, W.B. Isaacs and A.M. de Marzo,2004215120Yu, H.P., S.Q. Xu, L. Liu, L.Y. Shi and X.K. Cai et al.,2003198193201Hull, M.A.,20054118541863Bratthauer, G.L.,2010588257270Abd El-Ghani, S.F., R.F. Kasem, N.A. Ghallab and O.G. Shaker,201342781787Dell'Agli, M., G.V. Galli, E. Bosisio and M. Dambrosio,20091918581860Gong, Y., L. Wang, H. Wang, T. Li and X. Chen,200945515520Gadbail, A.R., M. Chaudhary, S. Patil and M. Gawande,200915490498Li, T.J., R.M. Browne and J.B. Matthews,199526219228Kumamoto, H. and K. Ooya,2005α, TNF-related apoptosis-inducing ligand and their associated molecules in ameloblastomas.]]>34287294Zhang, J. and B. Peng,2009in vitro.]]>42150161Wu, W., D.F. Yao, L.W. Qiu, W.L. Sai and J.J. Shen et al.,20098504509Fukuda, M., M. Ehara, S. Suzuki, Y. Ohmori and H. Sakashita,20103613551365Gonzalez-Gonzalez, R., N. Molina-Frechero, P. Damian-Matsumura, S. Salazar-Rodriguez and R. Bologna-Molina,20152015Tosios, K.I., E. Kakarantza-Angelopoulou and N. Kapranos,200029139144Lee, H.H., H. Dadgostar, Q. Cheng, J. Shu and G. Cheng,19999691369141Tamatani, M., Y.H. Che, H. Matsuzaki, S. Ogawa and H. Okado et al.,199927485318538Tsukahara, T., M. Kannagi, T. Ohashi, H. Kato and M. Arai et al.,19997379817987Khoshnan, A., C. Tindell, I. Laux, D. Bae, B. Bennett and A.E. Nel,2000L expression and for the anti-apoptotic effects of the CD28 receptor in primary human CD4+ lymphocytes.]]>16517431754Mendes, R.A., J.F. Carvalho and I. van der Waal,200945e124e128Gallo, O., E. Masini, B. Bianchi, L. Bruschini, M. Paglierani and A. Franchi,200233708714Mohan, S. and J.B. Epstein,200339537546Shibata, M., I. Kodani, M. Osaki, K. Araki, H. Adachi, K. Ryoke and H. Ito,200541304312Seyedmajidi, M., S. Shafaee, S. Siadati, E.A. Moghaddam, N. Ghasemi, A. Bijani and M. Najafi,201512278284Cecim, R.L., H.A. Carmo, M.S. Kataoka, V.M. Freitas and S. de Melo Alves Jr. et al.,201443143147Plummer, S.M., K.A. Holloway, M.M. Manson, R.J. Munks, A. Kaptein, S. Farrow and L. Howells,19991860136020Tanabe, T. and N. Tohnai,20026895114Subbaramaiah, K. and A.J Dannenberg,20032496102