International Journal of Cancer Research1811-97271811-9735Academic Journals Inc.10.3923/ijcr.2015.93.103MansourAmal ShehataHanan AliMarwa SallamMaha KhoulyNoura El AsfourInas 22015112Angiogenesis has been shown as an important process in hematological malignancies especially leukemia, Vascular Endothelial Growth Factor (VEGF) plays a central role in promoting angiogenesis. Its different genotypes are associated with many human diseases. This study was to investigate the frequency of -460T/C and -1154G/A VEGF gene SNPs in adult ALL patients and their impact on serum concentration of VEGF and on the clinical outcome. Allele specific PCR for -460T/C and -1154G/A VEGF gene SNPs detection were done for 65 adult subjects (40 ALL patients and 25 normal healthy controls) and the serum VEGF was measured. Mean serum VEGF levels is higher in ALL than control subjects (p = 0.00) and it decreased markedly after complete remission (p = 0.00). There was marked association between TC genotype of -460T/C in ALL with higher association between the C allele and ALL than the T allele (p = 0.018) with high frequency of CA haplotype of -460 T/C and -1154 G/A in patients compared to control group (p = 0.019). Some VEGF genotypes may have impact on ALL pathogenesis and treatment outcome.]]>Aguayo, A., E. Estey, H. Kantarjian, T. Mansouri and C. Gidel et al.,19999437173721Aguayo, A., H. Kantarjian, T. Manshouri, C. Gidel and E. Estey et al.,20009622402245Aref, S., O. Salama, S. Shamaa, M. El-Refaie and H. Mourkos,200712319324Avramis, I.A., E.H. Panosyan, F. Dorey, J.S. Holcenberg and V.I. Avramis,20061269786984Awata, T., K. Inoue, S. Kurihara, T. Ohkubo and M. Watanabe et al.,20025116351639Chen, M.H., C.H. Tzeng, P.M. Chen, J.K. Lin and T.C. Lin et al.,201111227236Chien, M.H., Y.F. Liu, C.H. Hsin, C.H. Lin and C.H. Shih et al.,20132013Debrah, A.Y., S. Mand, M.R. Toliat, Y. Marfo-Debrekyei and L. Batsa et al.,200777601608Del Bo, R., S. Ghezzi, M. Scarlato, D. Albani and D. Galimberti et al.,20082919171922Demacq, C., V.B. Vasconcellos, T.C. Izidoro-Toledo, V. da Silva Silveira and R. Canalle et al.,201041113351340Duffy, A.M., D.J. Bouchier-Hayes and J.H. Harmey,20002000Gawad, T.A.A., A.A. Al Sharkawy, A. Mansour and A. Yousef,2012103943Folkman, J.,200657118Graux, C.,201144183189Huang, C., Y. Xu, X. Li and W. Wang,20131912111221Kalra, M., V. Dinand, S. Choudhary, A. Sachdeva and S.P. Yadav,201250659662Kammerer, P.W., F.P. Koch, E. Schiegnitz, V.V. Kumar and M. Berres et al.,201342374381Karjalainen, K., D.E. Jaalouk, C.E. Bueso-Ramos, A.J. Zurita and A. Kuniyasu et al.,2011117920927Kawai, Y., S. Sakano, Y. Korenaga, S. Eguchi and K. Naito,20075211471155Masetti, R. and A. Pession,20093359368Metz, C.E.,19788283298Molica, S., G. Cutrona, G. Vitelli, R. Mirabelli and M. Molica et al.,20073115751578Narayanan, S. and P.J. Shami,2012194102Rogers, M.S. and R.J. D'Amato,20122012Sanaat, Z., R. Khalili, S. Almasi, M.R. Aliparasti and S.M. Tavangar et al.,201482429Schneider, P., I. Dubus, F. Gouel, E. Legrand, J.P. Vannier and M. Vasse,20112011Stachel, D., M. Albert, R. Meilbeck, M. Paulides and I. Schmid,200717147152Sun, S.F., D.B. Huang, C. Cao and Z.C. Deng,20132013De Trovo, A.B.T.,201258620632Yang, H.Q., R.H. Zhang, Z.H. Zhang, C.C. Wan and Y.J. Xia,20079526528Yang, J., W. Li, X. He, G. Zhang, L. Yue and Y. Chai,20152015Yetgin, S., I. Yenicesu, M. Icletin and M. Tuncer,2001428388Yoshikawa, H., F. Dogruman-Al, S. Turk, S. Kustimur, N. Balaban and N. Sultan,2011Blastocystis subtypes from fecal samples.]]>10910451050Zarbock, R., D. Hendig, C. Szliska, K. Kleesiek and C. Gotting,20091833443351Zeng, D., J. Wang, P. Kong, C. Chang, J. Li and J. Li,2014721722178