International Journal of Cancer Research1811-97271811-9735Academic Journals Inc.10.3923/ijcr.2014.81.95MansourA.H. MohammedMohammed Amin AnwarRokia ElzafranyM.E. OmarNesreen Moustafa 22014102There is growing evidence that the ABO blood group system may play a role in
disease etiology. Studies conducted several decades ago, have demonstrated a
relationship between inherited human ABO and Rhesus blood groups and risk of
various malignancies. However, these findings are inconsistent and contradictory.
The objective was to perform analysis of ABO and Rhesus blood antigens distribution
among patients with various cancers including breast, hepatocellular, pancreatic,
gastric, skin, lung cancers, leukemia and lymphoma in Dakahlia, Egypt and to
assess their potential role in carcinogenesis. A total of 1131 cancer patients
(age 63.8±9.3, female/male, 215/916) and another 1200 healthy controls
(age 48.9±11.3, female/male, 348/852) were enrolled in this study. ABO
blood groups were determined using Tube method and Gel method. The anti-TF IgG
level and Von Willebrand factor were determined by enzyme-linked immunosorbent
assay. The distribution of blood type A was significantly higher among cancer
patients than among healthy controls (39.35 vs. 33.75%, p = 0.014), whereas,
the distributions of other blood types were similar between cases and controls
(p>0.05). Most cancers, especially gastrointestinal tumors were dominated
by male gender independent of age. Blood group A was associated with significantly
higher risk for malignancy including hepatocellular carcinoma, pancreatic and
breast cancers while biliary and esophageal cancer risk was significantly associated
with blood type B. We suggest that blood group A may elevate risk of cancer
and may play a role in its development.]]>Abu Dayyeh, B.K., M. Yang, B.C. Fuchs, D.L. Karl and S. Yamada et al.,2011141141149Aird, I., H.H. Bentall and J.A.F. Roberts,19531799801Akhtar, K., G. Mehdi, R. Sherwani and L. Sofi,20102010Anderson, D.E. and C. Haas,19845418451849Beardmore, J.A., F. Karimi and K. Booshehei,1983303522524Desai, P.R., L.H. Ujjainwala, S.C. Carlstedt and G.F. Springer,1995188175185Eastlund, T.,199838975988Ferrone, C.R., D.M. Finkelstein, S.P. Thayer, A. Muzikansky, C. Fernandez-del Castillo and A.L. Warshaw,20062428972902Franchini, M., E.J. Favaloro, G. Targher and G. Lippi,201249137149Garratty, G.,200014291301Giger, U., K. Stieger and H. Palos,20056613861392Gold, E.R., G.H. Tovey, W.E. Benney and F.J. Lewis,1959183892893Henderson, J., V. Seagroatt and M. Goldacre,199347287289Hoshida, Y., A. Villanueva, M. Kobayashi, J. Peix and D.Y. Chiang et al.,200835919952004Hussein, M.R.,200532191205Iodice, S., P. Maisonneuve, E. Botteri, M.T. Sandri and A.B. Lowenfels,20104633453350Jaff, M.S.,20105901905Jayant, K.,19718185188Jenkins, P.V. and J.S. O'Donnell,20064618361844Judd, W.J., E.A. Steiner and P.C. Knafl,199713132135Guleria, K., H.P. Singh, H. Kaur and V. Sambyal,20057189192Karakousis, C.P., E. Evlongmenos and O. Sun,1986332426Kobayashi, H., K.C. Boelte and P.C. Lin,200714377386Koprowski, H., Z. Steplewski, K. Mitchell, M. Herlyn, D. Herlyn and P. Fuhrer,19795957971Kurtenkov, O., K. Klaamas, S. Mensdorff-Pouilly, L. Miljukhina, L. Shljapnikova and V. Chuzmarov,200746316323Kurtenkov, O., L. Miljukhina, J. Smorodin, K. Klaamas, N. Bovin, M. Ellamaa and V. Chuzmarov,199938939943Liumbruno, G.M. and M. Franchini,201311491499Mantovani, A., P. Allavena, A. Sica and F. Balkwill,2008454436444Morelli, V.M., M.C. de Visser, N.H. van Tilburg, H.L. Vos, J.C. Eikenboom, F.R. Rosendaal and R.M. Bertina,200797534541Nakao, M., K. Matsuo, S. Hosono, S. Ogata and H. Ito et al.,201110210761080Okada, Y., T. Arima, K. Togawa, H. Nagashima and K. Jinno,1987781928Pare, G., D.I. Chasman, M. Kellogg, R.Y.L. Zee and N. Rifai et al.,20082008Pelzer, U., F. Klein, M. Bahra, M. Sinn, B. Dorken, P. Neuhaus, O. Meyer and H. Riess,20132013Pittet, J.L., V. Barbalat, M. Sanvert, C. Villard, S. Jorieux and C. Mazurier,19978209215Poujol-Robert, A., P.Y. Boelle, D. Wendum, R. Poupon and A. Robert,20065116331636Qi, L., M.C. Cornelis, P. Kraft, M. Jensen and R.M. van Dam et al.,20101918561862Rumsey, D.H. and D.J. Ciesielsky,200016131137Sailaja, K. and D. Rao,20042004pp: 122123Schleef, M., E. Strobel, A. Dick, J. Frank, W. Schramm and M. Spannagl,2004128100107Sherman, M.,201042S215S222Storry, J.R. and M.L. Olsson,2009254859Surekha, D., A. Shrinivisan, K. Sailaja, D.N. Rao and S. Vishnupriya,20042004pp: 122Tryggvadottir, L., H. Tulinius and J.M. Robertson,198842499501Tursen, U., E.N. Tiftik, S. Unal, O. Gunduz, T.I. Kaya, H. Camdeviren and G. Ikizoglu,20052005Tyagi, S.P., S. Pradhan and S.S. Agarwal,196545645650Vioque, I. and A.M. Walker,199196761764Wolpin, B.M., A.T. Chan, P. Hartge, S.J. Chanock and P. Kraft et al.,2009101424431Dandona, M., F. Gao, D.C. Linehan and A. Wang-Gillam,2010102135137Wolpin, B.M., P. Kraft, M. Gross, K. Helzlsouer and H.B. Bueno-de-Mesquita et al.,20107010151023Woo, S.M., J. Joo, W.J. Lee, S.J. Park and S.S. Han et al.,201328247251Xie, J., A.A. Qureshi, Y. Li and J. Han,20102010