International Journal of Cancer Research1811-97271811-9735Academic Journals Inc.10.3923/ijcr.2014.27.36BusambwaK. Miller-CebertR.L. AboagyeL. DalrympleL. BoatengJ. ShackelfordL. WalkerL.T. VergheseM. 12014101Peas (yellow and green) and lentils contain bioactive compounds with protective
properties. Sprouting of grains has shown to improve nutritional value due to
activation of hydrolytic enzymes. The aim of this study was to determine anticarcinogenic
potential of sprouted and non-sprouted green-split and yellow peas and lentils
at 5 and 10% on Azoxymethane (AOM)-induced Aberrant Crypt Foci (ACF) in Fisher
344 male rats. Seventy-eight rats were randomly assigned to 13 groups: Control
(C) received AIN-93G diet; treatment diets included Lentils sprouted and non-sprouted
(LS, LNS), Green peas sprouted and non-sprouted (GS, GNS), Yellow peas sprouted
and non-sprouted (YS, YNS) at 5 and 10% levels in an AIN 93 based diet. At 7
and 8 week, rats received 2 subcutaneous injections of AOM at 16 mg kg-1
b.wt. Rats were euthanized at 17 week by CO2 Asphyxiation. Total
ACF ranged from 88 to 181.33 in rats fed C, LS and LNS, GS and GNS, YS and YNS.
ACF reductions (%) compared to C were 68.56; 63.25 and 51.46 in rats fed LS
at 10%, LNS at 10% and YNS at 10%, respectively. Glutathione content, Glutathione-S-transferase
and Catalase activities were significantly higher (p<0.05) in rats fed treatment
diets compared to C. Findings from this study indicate that sprouted and non
sprouted green split and yellow peas and lentils reduced AOM-induced aberrant
crypt foci in F344 male rats with the greatest reduction in rats fed Lentil
sprouted (10%). Selected legumes appear to have beneficial potential in reducing
colon cancer.]]>ACS,2009-20102009-2010ACS,20112011Bird, R.P.,198737147151Bird, R.P.,1995935571Boateng, J.A., M. Verghese, L.T. Walker, L.A. Shackelford and C.B. Chawan,2007Phaseolus spp L) on azoxymethane-induced formation of aberrant crypt foci in Fisher 344 male rats.]]>27640646Boateng, J., M. Verghese, V. Panala, L.T. Walker and L. Shackelford,20095153166Bolton, R.P., K.W. Heaton and L.F. Burroughs,198134211217Casaril, M., F. Corso, A. Bassi, F. Capra and G.B. Gabrielli et al.,1994249497Chavan, J.K., S.S. Kadam and L.R. Beuchat,198928401437Chen, J. and X.F. Huang,2009813131317Faris, M.A.I.E., H.R. Takruri, M.S. Shomaf and Y.K. Bustanji,2009Lens culinaris L.) and soybeans (Glycine max) against azoxymethane-induced aberrant crypt foci.]]>29355362Fernandes, A.C., W. Nishida and R.P. Da Costa Proenca,2010Phaseolus vulgaris L.) cooked with or without the soaking water: A review.]]>4522092218Folhe, L. and F. Otting,198410593104FAOUN,20102010Giovannucci, E.,200231925943Giovannucci, E. and W.C. Willett,199426443452Griffith, O.W.,1980106207212Habig, W.H., M.J. Pabst and W.B. Jakoby,197424971307139Hedges, L.J. and C.E. Lister,20062006Johansson, L.H. and L.A. Borg,1988174331336Kanda, B., J. Boateng, L. Shackelford, S. Appiah, K. Campbell L.T. Walker and M. Verghese,2012Prunus persica) in reducing azoxymethane (AOM) induced Aberrant Crypt Foci (ACF) in fisher 344 male rats.]]>8114Liu, R.H.,200378517S520SNCI.,20082008Pham, T.M., Y. Fujino, M. Ando, K. Suzuki and K. Nakachi et al.,2009107579Platz, E.A., W.C. Willett, G.A. Colditz, E.B. Rimm, D. Spiegelman and E. Giovannucci,200011579588Rajamanickam, S. and R. Agarwal,200869460471Reeves, P.G.,1997127838S841SRoy, F., J.I. Boye and B.K. Simpson,201043432442Satomi, A., S. Murakami, T. Hashimoto, K. Ishida, M. Matsuki and M. Sonoda,199530177182Shirtliff, N. and R.P. Bird,19961720932096Skrzycki, M., M. Majewska, M. Podsiad and H. Czeczot,200956663670Takayama, T., S. Katsuki, Y. Takahashi, M. Ohi and S. Nojiri et al.,199833912771284Xu, B. and S.K.C. Chang,20105815091517