International Journal of Cancer Research1811-97271811-9735Academic Journals Inc.10.3923/ijcr.2013.9.23AbouzeinabN.S. 1201391Cisplatin (CDDP) is a potent anticancer agent associated with a variety of toxicities. The present study was carried out to investigate the cytoprotective and antioxidant activities of silymarin (SIL) on CDDP induced toxicity. Hepatotoxicity was manifested biochemically from increased activities of Aspartate Transaminase (AST), Alanine Transaminase (ALT), glucose concentration in serum, a markedly increased level of liver lipid peroxidation (malondialdehyde, MDA) associated with significantly reduced activities of the antioxidant enzymes: superoxide dismutase (SOD) and glutathione peroxidase (GPx) in CDDP group. CDDP induced histochemical alterations including: a significant depletion in glycogen stores, total protein and DNA contents in liver cells. 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