International Journal of Cancer Research1811-97271811-9735Academic Journals Inc.10.3923/ijcr.2011.135.143Macrosolen parasiticus (L.) Danser on Ehrlich's Ascites Carcinoma Treated Mice]]>SoddeV. DashoraN. PrabhuK.S. LoboR. 2201172The present study was undertaken is to explore the anticancer activity of the methanolic and aqueous stem extract of the Macrosolen parasiticus in Swiss albino mice against Ehrlich Ascites Carcinoma (EAC) cell line. The activity of ethanolic and aqueous extracts of Macrosolen parasiticus was evaluated in Swiss albino mice against Ehrlich Ascites Carcinoma (EAC) cell line at the doses of 150 and 300 mg kg-1 body weight orally. Both extracts at both doses were administered for 13 consecutive days. Twenty four hours of last dose and eighteen hours of fasting, the mice were sacrificed and anti cancer effect of methanolic and aqueous extracts assessed by evaluating tumor volume, viable and nonviable tumor cell count, tumor weight and hematological parameters of EAC bearing host. The both the extracts showed significant decrease in (p<0.0001) tumor volume, viable cell count, tumor weight and elevated the life span of EAC tumor bearing mice. Haematological profile such as RBC, haemoglobin and WBC count reverted to normal level in treated mice. From the result it was demonstrated that the extract has potent dose dependent anticancer activity and that is comparable to that of cisplatin. Aqueous extract at both doses (150 and 300 mg kg-1) and methanolic extract at 300 mg kg-1 dose showed potent anticancer activity. Further investigation to explore the potential of the aqueous extracts of M. parasiticus in tumor treatment may prove to be worthwhile as a natural source of the drug.]]>English, D.R., B.K. Armstrong, A. Kricker and C. Fleming,19978271283Fenninger, L.D. and G.B. Mider,19541954pp: 229-253pp: 229-253Fotsis, T., M.S. Pepper, E. Aktas, S. Breit and S. Rasku et al.,1997in vitro angiogenesis.]]>5729162921Gopal, M., S. Shenoy and L.S. Doddamani,2003726978Hafidh, R.R., F. Abas, A.S. Abdulamir, F. Jahanshiri, F. Abu Bakar and Z. Sekawi,200956982Hogland, H.C.,1982995102Jeyachandran, R., A. Mahesh and L. Cindrella,2007Anisomeles malabarica (L.) R.Br. ethanolic leaf extract in male albino mice.]]>3174179Jones, P.J. and S.S. AbuMweis,200912147151Mackay, J., A. Jemal, N. Lee and M. Parkin,2006pp: 20-25pp: 20-25Karthikeyan, R., S. Karthigayan, M. Sri Balasubashi, S. Vijayalakshni and T. Balasubramanian,2007Hydrophis spiralis) on ehrlich ascites carcinoma bearing mice.]]>3167173Kaufman, D. and B.A. Chabner,19961996pp: 1-16pp: 1-16Kuper, H., P. Boffetta and H.O. Adami,2002252206224Litchfield, Jr. J.T. and F. Wilcoxon,19499699113Mitsuaki, M., N. Ikuo, H. Masako, T. Yutaka and Y. Kunio,1981115155161Nelson, D.A., T.T. Tan, A.B. Rabson, D. Anderson, K. Degenhardt and E. White,20041820952107Newman, D.J., G.M. Cragg and K.M. Snader,20036610221037Price, V.E. and R.E. Greenfield,19581958pp: 199-200pp: 199-200Saalu, L.C., G.O. Ajayi, A.A. Adeneye, I.O. Imosemi and A.A. Osinubi,2009Citrus paradisi Macfad) as an effective attenuator of doxorubicin-induced oxidative stress in the rat heart.]]>54452Sur, P. and D.K. Ganguly,199460106109Sodde, V., N. Dashora, K. Prabhu, B. Jaykumar and R. Lobo,2011Macrosolen parasiticus (L.) danser stem-a common parasitic medicinal plant.]]>2217221Kumar, R.S., B. Jayakar and B. Rajkapoor,20073180185