International Journal of Cancer Research1811-97271811-9735Academic Journals Inc.10.3923/ijcr.2009.36.43Spirulina sp. Against Cancer in Experimental Animals]]>Bin-MeferijMashael Mohammed 1200951The present study aims to study the possible effect
of the cyanobacterium Spirulina sp. as a protective agent in rats
given diethylnitrosamine (DEN) in drinking water. The investigation is
supposed to carried out through histopathological and immunohistochemical
examinations for proliferation marker Ki67 in liver tissues. The hepatoprotective
role of Spirulina shown by the histopathological examination of
the liver where only little dilatation in the blood sinusoids, slight
vacuolization in the cytoplasm and few pyknotic nuclei were observed.
Immunohistochemical evaluation shown reduction of the number of malignant
cells and its proliferation in treated group, but the Ki67 expression
was high labeling index in DEN induced heptocarcinoma group. Also, liver
Ki67 labeling index (Ki67 LI) in tumor tissues or adjacent non-tumor tissues
were higher than that in normal liver tissues, while in tumor tissues
it was higher than that in adjacent non-tumor tissues. So, using Spirulina
seems to have realistic results and rapid curative effect. The development
of specific therapeutic strategies based on natural algal products should
be considered as an attractive approach. Based on these fascinating possibilities,
Spirulina offers a great promise for patients with liver injury
and Ki67 expression could represent a valuable tool in the understanding
of hepatocellular carcinoma.]]>Ayehunie, S., A. Belay, T.W. Baba and R.M. Ruprecht,1998Spirulina platensis (Arthrospira platensis).]]>18712Benjamin, H.S.L., P.T. Padma and M.T. Jeffrey,199010937948Clement, G.,1975Spirulina platensis and Spirulina maxima.]]>29477488Cohen, M.B., F.M. Waldman, P.R. Carroll, R. Kerschmann, K. Chew and B.H. Mayall,199324772778Dillon, J.C., A.P. Phuc and J.P. Dubacq,1995Spirulina.]]>773246Estrada, J.E.P., P.B. Bescós and A.M.V. del Fresno,2001Spirulina platensis protean extract.]]>56497500Feo, F., R.M. Pascale, M.M. Simile, M.R. De Migilo, M.R. Muroni and D. Calvisi,2000111962Grundy, S.M.,199123187193Hayashi, K., T. Hayashi and N. Mortia,1993Spirulina platensis is a selective inhibitor of Herpes simplex virus type 1 penetration into HeLa cells.]]>77680Hayashi, T., K. Hayashi, M. Maeda and I. Kojima,1996Spirulina platensis.]]>598387Hayashi, K., T. Hayashi and I. Kojima,1996Spirulina platensis: In vitro and ex vivo evaluation of anti-herpes simplex virus and anti-human immunodeficiency virus activities.]]>1214631471Hirahashi, T., M. Matsumoto, K. Hazeki, Y. Saeki, M. Ui and T. Seya,2002Spirulina platensis.]]>2423434Ismail, M.F., Y.A. Azab, D.A. Ali, E.K. Abd Elhady and S.K. Areida et al.,2006Spirulina platensis on experimentally induced bladder cancer in rats.]]>33114Ke, L., P. Yu, Z.X. Zhang, S.S. Huang, G. Huang and X.H. Ma,200286346347Khan, Z., P. Bhadouria and P.S. Bisen,2005Spirulina.]]>6373379Pang, Q.S., B.J. Guo and J.H. Ruan,1988Spirulina platensis].]]>15374381, (In Chinese)Pardhasaradhi, B.V.V., A.A. Mubarak, A.L. Kumari, P. Reddanna and A. Khar,2003211651170Premkumar, K., S.K. Abraham, S.T. Santhiya and A. Ramesh,2004Spirulina fusiformis on chemical-induced genotoxicity in mice.]]>752431Qureshi, M.A., J.D. Garlich and M.T. Kidd,1996Spirulina platensis enhances humoral and cell-mediated immune functions in chickens.]]>18465476Robbins, S.L. and D. Angell,19762nd Edn.,Sabourdy, M.A.,1988Volume 1,Su, L.J. and L. Arab,20025419426Tantawy, A., T. Borg, L. Eissa, E.M. Marwan, I. Ismail and Y. Azab,2004Spirulina platensis tablets on the level of iron and protein in rabbits.]]>18119123Thapliyal, R., S.S. Deshpande and G.B. Maru,20021757988Ha, W.S., C.K. Kim, S.K. Song and C.B. Kang,200125358