American Journal of Drug Discovery and Development2150-427x2150-4296Academic Journals Inc.10.3923/ajdd.2017.48.53Al-NimerMarwan Salih Mohamud AhmedRozhgar Faisal 1201771Background and Aim: Diuretics used as a first line therapy in the management of hypertension. Spironolactone is the fourth drug that
indicated in the management of resistant hypertension. This study aimed to clarify the importance of using short term therapy for 2 weeks
as add on therapy in the management of uncontrolled-resistant hypertension. Materials and Methods: A total number of 120 patients
were enrolled in open label clinical study. The patients are assigned to receive 2 week therapy of a single daily dose of amiloride (5 mg)
plus hydrochlorothiazide (50 mg) (Group I), or 50 mg spironolactone (Group II) or 50 mg hydrochlorothiazide (Group III). The following
measurements, including the anthropometric measurement, blood pressure, lipid profile and serum electrolytes were considered.
Results: Diuretics produced significant reduction of the blood pressure of systolic and diastolic that amounted 23 and 14.2%
(Group I), 24.3 and 14.4% (Group II) and 25.4 and 13.0% (Group III) of the baseline value. They induced alterations in serum electrolytes
in Group II and III. Conclusion: Two- week therapeutic regimens of diuretics are enough to achieve the control of blood pressure and the
logic drug for resistant hypertension is spironolactone.]]>Blowey, D.L.,20163122232233Musini, V.M., M. Nazer, K. Bassett and J.M. Wright,20142014Pareek, A.K., F.H. Messerli, N.B. Chandurkar, S.K. Dharmadhikari and A.V. Godbole et al.,201667379389Sica, D.A., B. Carter, W. Cushman and L. Hamm,201113639643Chan, C.Y., E.J. Peterson and T.M. Ng,20124615541558Musini, V.M., P. Rezapour, J.M. Wright, K. Bassett and C.D. Jauca,20122012Izzo, Jr. J.L. and S.W. Tobe,201610282284Dudenbostel, T. and D.A. Calhoun,201730103109Verdalles, U., M. Goicoechea, S.G. de Vinuesa, B. Quiroga and I. Galan et al.,201636523529, (In Spanish)Lane, D.A. and D.G. Beevers,20072525152516Eide, I.K., P.A. Torjesen, A. Drolsum, A. Babovic and N.P. Lilledahl,20042222172226Corea, L., M. Bentivoglio and P. Verdecchia,19833367370Oliveras, A., P. Armario, A. Clara, L. Sans-Atxer, S. Vazquez, J. Pascual and A. de la Sierra,20163418631871Batterink, J., S.N. Stabler, A.M. Tejani and C.T. Fowkes,20102010Chaturvedi, S., D.H. Lipszyc, C. Licht, J.C. Craig and R. Parekh,20149498580Williams, B., T.M. MacDonald, S. Morant, D.J. Webb and P. Sever et al.,201538620592068Greathouse, M.K. and M.R. Weir,20121244052Izzo, Jr. J.L., Y. Jia and D.H. Zappe,201719143150Roush, G.C. and D.A. Sica,20162911301137