Asian Journal of Clinical Nutrition1992-14702077-2033Asian Network for Scientific Information10.3923/ajcn.2014.41.46M. ForestJaclyn RafikhahNaser 2201462Green tea is an ancient beverage and a famous herbal medicine. Recently, it has been used successfully as a topical preparation in acne patients. The objective of the present study was to examine the effectiveness of oral green tea extract in a group of patients with mild-to-moderate acne vulgaris. In this double-blind, placebo-controlled, randomized clinical trial, 34 volunteers with mild-to moderate acne vulgaris were randomly categorized in two, age and sex-matched groups, receiving either three capsules containing 500 mg aqueous extract of green tea in each (cases, n = 18), or placebo (controls, n = 16) three times daily for 30 consecutive days. Facial acne noninflamed, inflamed and total (noninflamed plus inflamed) lesion counts were documented at baseline, on week 2 and at endpoint (day 30) by an observer who was blind to the grouping of patients. In case group, there were 9 males (50%) and 9 females (50%) with a mean age of 14.3±1.8 years (range: 12-17). In control group, there were 11 males (68.8%) and 5 females (31.3%) with a mean age of 13.4±1.3 years (range: 12-16). The two groups were comparable for sex (p = 0.27) and gender (p = 0.11). The mean number of inflamed and total acne lesions decreased significantly more in the case group in comparison with that in the control group (p = 0.001 and 0.01, respectively). Similar difference was not found for noninflamed lesions (p = 0.33). This study showed that oral aqueous extract of green tea is effective against acne lesions in patients with mild-to-moderate disease.]]>Amirnia, M., E. Khodaeiani, R.F. Fouladi and A. Hashemi,201223109111Azimi, H., M. Fallah-Tafti, A.A. Khakshur and M. Abdollahi,20128313061317Babaeinejad, S., E. Khodaeiani and R.F. Fouladi,201122206210Babaeinejad, S.H. and R.F. Fouladi,20131210331038Baharivand, N., A. Mahdavifard and R.F. Fouladi,2013333946Bilgili, S.G., H.U. Ozkol, A.S. Karadag and O. Calka,201433214221Burke, B.M. and W.J. Cunliffe,19841118392Chung, J.H., J.H. Han, E.J. Hwang, J.Y. Seo and K.H. Cho et al.,20031719131915Daghighi, M.H., M. Pouriesa, M. Maleki, D.F. Fouladi, M.Z. Pezeshki, R.M. Khameneh and A.M. Bazzazi,20141419701977Dvorakova, K., R.T. Dorr, S. Valcic, B. Timmermann and D.S. Alberts,199943331335Elsaie, M.L., M.F. Abdelhamid, L.T. Elsaaiee and H.M. Emam,20098358364Fattahi, E., M.H. Somi, M.R. Moosapour and R.F. Fouladi,201114849853Feiz, H.H., A. Afrasiabi, R. Parvizi, A. Safarpour and R.F. Fouladi,2012467780Fisk, W.A., H.A. Lev-Tov and R.K. Sivamani,20142811371152Fouladi, R.F.,2012Berberis vulgaris L. in acne vulgaris, a clinical trial.]]>9253261Fouladi, R.F.,2013149250251Fowler, J.F. Jr., H. Woolery-Lloyd, H. Waldorf and R. Saini,20109S72S81Hsu, S.,20055210491059Jung, M.K., S. Ha, J.A. Son, J.H. Song and Y. Houh et al.,2012304655663Khodaeiani, E., R.F. Fouladi, M. Amirnia, M. Saeidi and E.R. Karimi,2013529991004Khodaeiani, E., R.F Fouladi, N. Yousefi, M. Amirnia, S. Babaeinejad and J. Shokri,201257279281Khondker, L. and S.I. Khan,201423181185Lee, H., S. Shim, M. Chung, S. Lim and K. Kim,2009 In vitro anti-adhesive activity of green tea extract against pathogen adhesion.]]>23460466Mahmood, T., N. Akhtar, B.A. Khan, H.M. Khan and T. Saeed,201010260264Navali, N., S. Pourabolghasem, R.F. Fouladi and M.A. Nikpour,201114658663Pazyar, N., A. Feily and A. Kazerouni,201210352355Pouriesa, M., R.F. Fouladi and S. Mesbahi,201313402407Rasheed, A., S.N. Shama, J.M. Joy, B.S. Reddy and C. Roja,201225867870Shakeri, A., M. Abdi, H.T. Khosroshahi and R.F. Fouladi,201114844848Shakeri, A., M.B. Bazzaz, A. Khabbazi and R.F. Fouladi,201114812816Sharma, A., S. Gupta, I.P. Sarethy, S. Dang and R. Gabrani,2012135672675Stratton, S.P., J.L. Bangert, D.S. Alberts and R.T. Dorr,20001584752Tarzamni, M.K., N. Eshraghi, R.F. Fouladi, A. Afrasiabi, M. Halimi and A. Azarvan,201263622629Taylor, P.W., J.M.T. Hamilton-Miller and P.D. Stapleton,200527181Yoon, J.Y., H.H. Kwon, S.U. Min, D.M. Thiboutot and D.H. Suh,2013P. acnes.]]>133429440Sabeti, S., F. Malekzad, M. Ashayer, R.F. Fouladi, K.K. Hesari, M.P. Toutkaboni and S. Younespour,201358331336