Asian Journal of Clinical Nutrition1992-14702077-2033Asian Network for Scientific Information10.3923/ajcn.2014.29.34Aloe vera Juice and Acne Vulgaris: A Placebo-Controlled Study]]>M. ForestJaclyn RafikhahNaser 2201462Lately, it has been shown that topical Aloe vera extract is effective against acne lesions. The objective of this study was to investigate the effectiveness of oral Aloe vera juice in a group of patients with mild-to-moderate acne vulgaris. In this double-blind, placebo-controlled, randomized clinical trial, 40 volunteers with mild-to moderate acne vulgaris were randomized equally into two, age and sex-matched groups, receiving either 50 cc of freshly prepared Aloe vera (Aloe barbadensis Miller) juice or placebo once daily for 30 consecutive days. Facial acne noninflamed, inflamed and total (noninflamed plus inflamed) lesion counts were documented at baseline on week 2 and at endpoint (day 30) by an observer who was blind to the grouping of patients. There were 12 males (60%) and 8 females (40%) with a mean age of 17.5±5.1 years (range: 12-27) in the case group and 10 males (20%) and 10 females (20%) with a mean age of 17.4±5.6 years (range: 12-29) in the control group (p = 0.53 and 0.98, respectively). Although, the mean number of inflamed and total acne lesions decreased from baseline to the endpoint in the case group, these changes were not statistically different from those documented in the control group (p = 0.96 and 0.91, respectively). In conclusion, oral Aloe vera juice may be helpful in decreasing noninflamed and total facial acne lesion counts in patients with mild-to-moderate acne vulgaris, this beneficial effect is not significant when compared to controls.]]>Admani, S. and V.R. Barrio,201326462466Amirnia, M., E. Khodaeiani, R.F. Fouladi and A. Hashemi,201223109111Babaeinejad, S., E. Khodaeiani and R.F. Fouladi,201122206210Babaeinejad, S.H. and R.F. Fouladi,20131210331038Baharivand, N., A. Mahdavifard and R.F. Fouladi,2013333946Burke, B.M. and W.J. Cunliffe,19841118392Chithra, P., G.B. Sajithlal and G. Chandrakasan,1998Aloe vera on the healing of dermal wounds in diabetic rats.]]>59195201Daghighi, M.H., M. Pouriesa, M. Maleki, D.F. Fouladi, M.Z. Pezeshki, R.M. Khameneh and A.M. Bazzazi,20141419701977Fattahi, E., M.H. Somi, M.R. Moosapour and R.F. Fouladi,201114849853Feiz, H.H., A. Afrasiabi, R. Parvizi, A. Safarpour and R.F. Fouladi,2012467780Fouladi, R.F.,2012Berberis vulgaris L. in acne vulgaris, a clinical trial.]]>9253261Fouladi, R.F.,2013149250251Fulton, J.E., Jr.,199016460467Habeeb, F., E. Shakir, F. Bradbury, P. Cameron and M.R. Taravati et al.,200742315320Habeeb, F., G. Stables, F. Bradbury, S. Nong, P. Ameron, R. Plevin and V.A. Ferro,200742388393Hajheydari, Z., M. Saeedi, K. Morteza-Semnani and A. Soltani,2014Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: A randomized, double-blind, prospective trial.]]>25123129Hamman, J.H.,20081315991616Jain, A. and E. Basal,2003Propionibacterium acnes-induced mediators of inflammation by Indian herbs.]]>103438Kanlayavattanakul, M. and N. Lourith,201133289297Khodaeiani, E., R.F. Fouladi, M. Amirnia, M. Saeidi and E.R. Karimi,2013529991004Khodaeiani, E., R.F Fouladi, N. Yousefi, M. Amirnia, S. Babaeinejad and J. Shokri,201257279281Lalla, J.K., S.Y. Nandedkar, M.H. Paranjape and N.B. Talreja,20017899102Lawrence, R., P. Tripathi and E. Jeyakumar,2009Aloe vera.]]>40906915Nagpal, R., V. Kaur, M. Kumar and F. Marotta,2012Aloe vera juice on growth and activities of Lactobacilli in-vitro.]]>83183188Navali, N., S. Pourabolghasem, R.F. Fouladi and M.A. Nikpour,201114658663Pouriesa, M., R.F. Fouladi and S. Mesbahi,201313402407Reynolds, T. and A.C. Dweck,1999Aloe vera leaf gel: A review update.]]>68337Saeedi, M., K. Morteza-Semnani and M.R. Ghoreishi,200314153157Shakeri, A., M. Abdi, H.T. Khosroshahi and R.F. Fouladi,201114844848Shakeri, A., M.B. Bazzaz, A. Khabbazi and R.F. Fouladi,201114812816Tarzamni, M.K., N. Eshraghi, R.F. Fouladi, A. Afrasiabi, M. Halimi and A. Azarvan,201263622629Tunon, H., C. Olavsdotter and L. Bohlin,1995486176Vinson, J.A., H. Al Kharrat and L. Andreoli,2005Aloe vera preparations on the human bioavailability of vitamins C and E.]]>12760765Vogler, B.K. and E. Enst,1999Aloe vera a systematic review of its clinical effectiveness.]]>49823828Chularojanamontri, L., P. Tuchinda, K. Kulthanan and K. Pongparit,201473644Sabeti, S., F. Malekzad, M. Ashayer, R.F. Fouladi, K.K. Hesari, M.P. Toutkaboni and S. Younespour,201358331336