Asian Journal of Biochemistry1815-99231815-9931Academic Journals Inc.10.3923/ajb.2017.91.98Nymphaea lotus Aqueous Extract on Hyperprolactinemic Female Wistar Rats]]>SharaibiOlubunmi Josephine AfolayanAnthony Jide 32017123Background and Objective: Nymphaea lotus (N. lotus) is a medicinal plant used in traditional medicine for the management of hyperprolactinemia and infertility-related diseases. This aim of the study was to investigate the biochemical and hormonal effects of aqueous extract of N. lotus in metoclopramide-induced hyperprolactinemia in rats. Methodology: Hyperprolactinemia was induced by oral administration of 5 mg kg1 b.wt., metoclopramide to female rats. This was accompanied by administration of graded doses (50, 100 and 200 mg kg1 b.wt.,) of N. lotus to the rats daily for 21 days, while distilled water and bromocriptine were given to the hyperprolactinemia control and positive control, respectively. Biochemical and hormonal parameters were determined at the end of the experiment using the uterine homogenates and serum, respectively. Results: Significant increase (p<0.05) were observed in the serum prolactin and estradiol level, while follicle stimulating hormone (FSH), luteinizing hormone(LH) and progesterone witnessed reduction, following induction of hyperprolactinemia. Administration of aqueous extract of N. lotus significantly improved (p<0.05) the levels of these hormones especially prolactin and progesterone. It also tends to restore uterine glucose, cholesterol and protein concentration. Conclusion: Aqueous extract of N. lotus especially at dosage of 200 mg kg1 b.wt., could ameliorate hyperprolactinemia in rats.]]>Wiersema, N.J., A.J. Drukker, M.B.T. Dung, G.H. Nhu, N.T. Nhu and C.B. Lambalk,20062006Larsen, S.H., G. Wagner and B.L. Heitmann,20073111891198Torre, D.L. and A. Falorni,20073929951Melmed, S., F.F. Casanueva, A.R. Hoffman, D.L. Kleinberg, V.M. Montori, J.A. 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