Asian Journal of Biochemistry1815-99231815-9931Academic Journals Inc.10.3923/ajb.2014.187.194VashistM.G. DeswalS. VermaM. KharbS. 4201494Deep Vein Thrombosis (DVT) affects a significant proportion of population and
if untreated timely leads to high mortality due to pulmonary embolism. Though
color Doppler ultrasonography is the gold standard for diagnosis but non availability
of experienced radiologist especially at night has led to alternative investigation
for diagnosis of DVT. Plasma D-dimer levels which measure the degradation products
of cross linked fibrin, are a valuable diagnostic test for the exclusion of
deep venous thrombosis. D-dimer levels were analyzed in fifty patients suspected
of deep vein thrombosis clinically and compared the results with color Doppler
ultrasonography. A value of 250 ng mL-1 was chosen as cut off. For
the purposes of analysis, results were expressed as either negative (<250
ng mL-1) or positive (≥250 ng mL-1). Patients were
classified as low, moderate or high pretest probability for DVT as per Well s
scoring system. D-dimer assay had a sensitivity of 97.3% (CI 85.8-99.9%), a
specificity of 38.5% (CI 13.9-68.4%), a positive predictive value of 81.8% (CI
67.3-91.8%) and a negative predictive value of 83.3% (CI 35.9-99.6%). In patients
with a low or moderate pretest probability of DVT, the negative predictive value
of this assay was 100% and this test can safely exclude the DVT in these patients.
Thus in patients having low and moderate pretest probability automated latex
D-dimer test can safely exclude DVT.]]>Anderson, F.A., H.B. Wheeler, R.J. Goldberg, D.W. Hosmer and N.A. Patwardhan et al.,1991151933938Barnes, R.W., K.K. Wu and J.C. Hoak,1975234605607Cranley, J.J., A.J. Canos and W.J. Sull,19761113436Haeger, K. and A. Sjukhuset,196920219223Kakkar, V.V., C.T. Howe, C. Flanc and M.B. Clarke,1969294230233Sumner, D.S. and M.A. Mattos,19931993pp: 785-800pp: 785-800Lewis, B.D., E.M. James, T.J. Welch, J.W. Joyce, J.W. Hallett and A.L. Weaver,1994192651655Vaccaro, J.P., J.J. Cronan and G.S. Dorfman,1990175645649Cogo, A., A.W. Lensing, M.M. Koopman, F. Piovella and S. Siragusa et al.,19983161720Birdwell, B.G., G.E. Raskob, T.L. Whitsett, S.S. Durica, J.N. George, T.L. Tytle and P.A. McKee,199812817Bernstein, F.E.,19841984pp: 1367-1368pp: 1367-1368Lensing, A.W., P. Prandoni, D. Brandjes, P.M. Huisman and M. Vigo et al.,1989320342345Wells, P.S., D.R. Anderson, M. Rodger, M. Forgie and C. Kearon et al.,200334912271235Villa, P., F. Ferrando, J. Serra, H. Faus, Y. Mira, A. Vaya and J. Aznar,200085520524Hansson, P.O., L. Welin, G. Tibblin and H. Eriksson,199715716651670Sebastian, M.W. and D.C. Sabiston,19971997pp: 1594-1607pp: 1594-1607Schutgens, R.E., E.U. Esseboom, F.J. Haas, H.K. Nieuwenhuis and D.H. Biesma,2002112617621Killick, S.B., P.G. Pentek, J.E. Mercieca, M.F. Clarke and D.H. Bevan,199796846849Diamond, S., R. Goldbweber and S. Katz,20051892326Bradley, M., J. Bladon and H. Barker,200055525527Sadouk, M.B., S. Desmarais, J.V. Patenaude and R. Lepage,200046286287Lindmarker, P., M. Holmstrom, S. Granqvist, H. Johnsson and D. Lockner,199472186190Harenberg, J., K. Huck, H. Bratsch, G. Stehle and C.E. Dempfle et al.,199020205219Green, R.M. and K. Ouriel,19991999pp: 1005-1009pp: 1005-1009Kontos, H.A.,19961996pp: 353-356pp: 353-356Hull, R.D., J. Hirsh, C.J. Carter, R.M. Jay and P.A. Ockelford et al.,19851022128Hull, R., J. Hirsh, D.L. Sackett, D.W. Taylor and C. Carter et al.,198164622625Huisman, M.V., H.R. Boller, J.W. ten Cate and J. Vreeken,1986314823828Heijboer, H., H.R. Buller, A. Lensing, A. Turpie, L.P. Colly and J.W. ten Cate,199332913651369Lee, A.Y., J.A. Julian, M.N. Levine, J.I. Weitz, C. Kearon, P.S. Wells and J.S. Ginsberg,1999131417423Wells, P.S., D.R. Anderson, J. Bormanis, F. Guy and M. Mitchell et al.,199735017951798Bick, R.L. and H. Kaplan,199882409458