Asian Journal of Biochemistry1815-99231815-9931Academic Journals Inc.10.3923/ajb.2012.59.62Rattus novergicus]]>JerohE. AwhinE.P. OsademeL. AwireE.I. 1201271The effect of carbonated drink also known as pop soda was studied in this research. The aim of this study was to check the possible effect on the activities of the kidney biomarkers [alanine aminotransferase (ALT) and aspartate aminotransferase (AST)] in Rattus novergicus. The results from this study revealed that the activities level of serum ALT of group A (24.1±5.8) showed a significant increase at (p<0.05) when compared with that of the control C (10.0±2.72) while that of group B (1.75±1.66) showed a significant decrease in enzyme activity when compared with that of the control. It was also revealed that there was significant increase in AST enzyme activity in brand B (24.2±6.38) when compared with that of the control C (17.0±1.94) at (p<0.05). The result from the investigation of kidney ALT and AST activities showed that there was a slight increase in AST activity with brand B (17.70±1.68) when compared with that of the control (16.70±2.52) at (p>0.05), While the kidney ALT level for brand A and B were reduced when compared with that of the control (p>0.05). The results of the study suggest that over consumption of carbonated drink may cause liver injury thereby increasing the liver enzyme activity, however overconsumption of carbonated drinks may cause problem to the kidney if there is alteration of kidney architecture. The results from the research showed that for healthy kidney, overconsumption of carbonated drinks may have no effect.]]>Adjene, J.O., J.C. Ezeoke. and E.U. Nwose,20102215217Bray, G.A., S.J. Nielsen and B.M. Popkin,200479537543Drills Jr., W.L.,199358779S787SHarnack, L., J. Stang and M. Story,199999436441Jugens, H., W. Haass, T.R. Casteneda, A. Sohurrmann and C. Kobriele et al.,20051311461156Malik, V.S., M.B. Schulze and F.B. Hu,200684274288Manuel, N.M., P. Alcada, R. Monteiro, C. Calhau and I. Azeveda,2006169315315Nielsen, S.J. and B.M. Popkin,200427205210Assy, N., G. Nasser, I. Kamayse, W. Nseir, Z. Beniashvili, A. Djibre and M. Grosovski,200822811816Vartaman, L.R., M.B. Schwartz and K.O. Brownwell,200797667675