Asian Journal of Biochemistry1815-99231815-9931Academic Journals Inc.10.3923/ajb.2012.54.58NandaNivedita BobbyZachariah HamideAbdoul 1201271Hypothyroidism is among the most common endocrine disorders in India. One of the most frequent causes of hypothyroidism is the autoimmune thyroid disease characterized by elevated Anti-thyroperoxidase Antibody (TPO Ab). We reported earlier the presence of Oxidative Stress (OS) in hypothyroid patients. In this study, we compared the level of OS in TPO Ab positive hypothyroid patients with TPO Ab negative hypothyroid patients which earlier has not been studied. We recruited untreated hypothyroid patients consecutively from the out patient department. We analyzed their TPO Ab titer, various biochemical and oxidative stress parameters and ultra-sensitive C reactive protein. The thiobarbituric acid reactive substances, an indicator of oxidative stress was significantly higher in TPO Ab positive hypothyroid patients compared to TPO Ab negative cases. TPO Ab titter positively correlated with the OS parameters and extent of low grade inflammation in TPO Ab positive hypothyroid patients. Oxidative stress was found to be more in TPO Ab positive untreated hypothyroid patients in our study indicating that autoimmunity could be one of the mechanisms contributing to the elevated OS level in hypothyroidism.]]>Friedewald, W.T., R.I. Levy and D.S. Fredrickson,197218499502Gerenova, J. and V. Gadjeva,200716259264Kochupillai, N.,20007910611067Krinsky, N.I.,1992200248254Kumagai, S.,20039210961103Kumagai, S., T. Jikimoto and J. Saegusa,200351126132Kurien, B.T. and R.H. Scofield,20087567573Levine, R.L., J.A. Williams, E.R. Stadtman and E. Shacter,1994233346357Libby, P.,20052005pp: 1425-1426pp: 1425-1426Mishkel, M.A. and S.M. Crowther,197774139151Nanda, N., Z. Bobby, A. Hamide, B.C. Koner and M.G. Sridhar.,20075613501355Nanda, N., Z. Bobby and A. Hamide,200846674679Portmann, L., N. Hamada, G. Heinrich and L.J. de Groot,19856110011003Satoh, K.,1978903743Tsotsonava, T., D. Virsaladze, K. Khitarishvili, T. Sanikidze and D. Tananashvili,20071463234Tsotsonava, T.A., D.K. Virsaladze, D.K. Khitarishvili and D.E. Tananashvili,20071455558Flynn, R.W., T.M. Macdonald, R.T. Jung, A.D. Morris and G.P. Leese,20069121592164