Asian Journal of Biochemistry1815-99231815-9931Academic Journals Inc.10.3923/ajb.2011.74.81Solanum trilobatum in Diethylnitrosamine Induced and Phenobarbital Promoted Heaptocarcinogenesis in Rats]]>JahanM.S. VaniG. ShyamaladeviC.S. 1201161Aim of the study is found the anticancer effect of ST on chemically induced hepatocellular carcinoma. The methanolic extract of Solanum trilobatum (ST) prevented 2 stage carcinogenesis in Wistar rats induced by diethyl nitrosamine (DEN) and promoted with Phenobarbital (PB). Animals were induced for hepatic carcinoma with DEN (200 mg kg-1 b.wt. i.p.,), promoted with PB (0.05%) in basal diet for a period of 3 and 6 months. Animals were also co-treated with methanolic extract of ST (250 mg kg-1 b.wt. in DMSO orally) for the same period of time (DEN+PB+ST). Administration of ST significantly decreased the levels of tumor markers-carcinoembroynic antigen (CEA) and α-fetoprotein (AFP) in serum compared to their untreated counterparts and also favorably altered the marker enzymes AST, ALT, ALP, GGT and LDH in both serum and liver and 5nucleotidase in liver. These results show the antitumor effect of ST against DEN induced hepatocarcinogenesis.]]>Bailey, N.T.J.,1959pp: 200pp: 200Bergmeyer, H.U.,1974Vol. 4,Bose, C.H. and M. Mukherjee,1994773943King, J.,1965pp: 83-93pp: 83-93King, J.,1965pp: 191-208pp: 191-208King, J.,1965pp: 121-138pp: 121-138Kobayashi, T. and T. Kawakubo,19947319461953Leoppky, R.N.,19941994pp: 1-19pp: 1-19Luly, P., O. Barnabei and E. Tria,1972in vitro of plasma membrane bound (Na+-K+)-ATPase of rat liver.]]>282447452Macnab, G.M., J.M. Urbanowicz and M.C. Kew,1978385154Madhavan, S. and S. Balu,1999Solanum trilobatum Linn.: An Indian drug plant.]]>234346McIntyre, N. and S. Rosalki, 19921992pp: 39-71pp: 39-71Mohanan, P.V. and K.S. Devi,1997112219223Mohanan, P.V. and K.S. Devi,1997in vitro method.]]>17915Mohanan, P.V. and K.S. Devi,1998123141145Mohanan, P.V. and K.S. Devi,1996Solanum trilobatum and the effect of sobatum on tumour reduction in mice.]]>1107176Mohanan, P.V. and K.S. Devi,199817159164Mohanan, P.V., K. Rathinam and K.S. Devi,19963612327Patel, P.S., G.N. Rawal and D.B. Bala,1994154551Rocchi, E., Y. Seium, L. Camellini, G. Casalgrandi, A. Borghi, P. D`Alimonte and G. Cioni,1997266772Rosi, F., A. Tabucchi, F. Carluci, P. Galieni and F. Laukia et al.,199831269272Shahjahan, M., K.E. Sabitha, M. Jainu and C.S. Shyamala Devi,2004120194198Shahjahan, M., G. Vani and C.S. Shyamaladevi,2005Solanum trilobatum on the antioxidant status during diethyl nitrosamine induced and phenobarbital promoted hepatocarcinogenesis in rat.]]>156113123Jahan, M.S., G. Vani and C.S. Shyamaladevi,2007373549Sharma, A., R. Mathur and S. Skukla,199532120128Stark, A.A., E. Zeiger and D.A. Pagamo,199314183189Yoshiji, H., D. Nakae, T. Kinugasa, M. Matsuzaki, A. Denda, T. Tsujii and Y. Konishi,199164839842