Asian Journal of Biochemistry1815-99231815-9931Academic Journals Inc.10.3923/ajb.2009.133.139FarvinK.H.S. SurendrarajA. AnandanR. 4200944In the present study an attempt has been made to assess the cardioprotective effect of squalene on isoprenaline-induced myocardial infarction in male albino rats with respect to changes in the levels of endogenous antioxidant vitamins in heart tissue. Levels of endogenous antioxidants such as ascorbic acid, α-tocopherol and endogenous squalene content in heart tissue were determined. Significant (p<0.001) reduction was observed in the levels of ascorbic acid, α-tocopherol and endogenous squalene content in the heart tissue of isoprenaline administered rats compared to normal control rats. It is worth noting that, the prior administration of squalene at 2% level along with feed for 45 days significantly (p<0.001) reduced the isoprenaline-induced decline in the levels of these vitamins and restored the membrane bound squalene content at near normal. The results of the present study indicates that the cardioprotective effect of squalene might be ascribable to its antioxidant property thereby sharing the responsibility of these antioxidant vitamins in counteraction of free radicals generated during isoprenaline-induced oxidative stress.]]>Baker, H., O. Frank, B. de Angelis and S. Feingold,198021531536Chan, P., B. Tomlinson, C. B. Lee and Y.S. Lee,199636422427Rodriguez, A.D., P.A. Gonzalez, A. de la Rosa, M. Vargas, J. Ferrer and M. Garcia, 2005997781Farvin, K.H.S., R. Anandan, S.H.S. Kumar, K.S. Shiny, T.V. Sankar and P.G.V. Nair,20069531536Farvin, K.H.S., R. Anandan, S.H.S. Kumar, K.S. Shiny, T.V. Sankar and T.K. Thankappan,200450231236Farvin, K.H.S., R. Anandan, T.V. Sankar and P.G.N. Viswanathan,2005375560Farvin, K.H.S., S.H.S. Kumar, R. Anandan , S. Mathew, T.V. Sankar and P.G.V. Nair,200710513901395Frei, B., L. England and B.N. Ames,19898663776381Freiglben, H.J. and L. Packer, 199321325333Gilbert, A. and J. Baggott,1991pp: 512-516pp: 512-516Hauβ, T., S. Dante, N.A. Dencher and T.H. Haines,20021556149154Ivashkevich, S.P., L.I. Apukhovskaia and V.P. Vendt,19814614201425Ko, T.F., T.M. Weng and R.Y. Chiou,20025053435348Kushi, L.H.,19996913221329Liu, G.C.K., E.H.Jr. Ahrens, P.H. Schreibman and J.R. Crouse,1976173845Miyachi, Y., T. Horio and S. Imamura,19838305310Molyneux, C.A., M.C. Glyn and B.J. Ward,200264265277Pinelli, A., S. Trivulzio, L. Tomasoni, S. Brenna, E. Bonacina and R. Accinni,200423277285Qureshi, A.A., J.W. Lehman and D.M. Peterson,199612619721978Qureshi, A.I., A.M. Siddiqui, M.F. Suri, S.H. Kim and Z. Ali et al.,20025113191329Roe, J.M. and C.A. Kuether, 1942147399407Singh, R.B., M.A. Niaz, S.S. Rastogi and S. Rastogi,199677232236