Asian Journal of Biochemistry1815-99231815-9931Academic Journals Inc.10.3923/ajb.2008.19.25UmarR.A. HassanS.W. LadanM.J. MatazuI.K. ShehuB. ShehuR.A. MuhammedL.G. MolaboF.I. 1200831We studied the effects of acute and sub-chronic oral administration of
nevirapine, lamivudine and stavudine on liver function in albino rats.
Acute administration of nevirapine resulted in significant (p<0.05)
increases in activities of Aspartate amino transferase (AST) and Alanine
amino transferase (ALT). Total proteins, albumin and globulin were significantly
lowered. Upon sub-chronic administration of nevirapine, only AST and ALT
activities were significantly raised. Acute administration of lamivudine
was associated with significantly (p<0.05) lower albumin and globulin
and higher total bilirubin and conjugated bilirubin levels. There were
no significant differences (p>0.05) in liver function profiles associated
with sub-chronic administration of the drug. However, acute and sub-chronic
administrations of stavudine were not associated with significant (p>0.05)
changes in liver function profiles. We conclude that while the use of
stavudine is safe, acute and sub-chronic oral administration of nevirapine
and lamivudine are associated with hepatotoxicity and hepatoprotective
agents should be incorporated in the treatment regimens employing these
drugs to avert life-threatening complications.]]>Abatan, M.O., R.O.A. Arowolo and O. Olorunsogo,1996Lantana camara and Dichapetalum madagascasiense in goats.]]>14127132Anderson, N.,2005331785786Anonymous,20002000Anonymous,20012001Anonymous,200336212671274Bartlett, J.G. and J.E. Gallant,20032003Beaune, P., P.M. Dansette, D. Mansuy, L. Kiffel and M. Finck et al.,198784551555Benjamin, M.M.,19783rd Edn.,pp: 229-232pp: 229-232Fistche, M.A., C.B. Parker and C. Pettineli,1990323200202Gebrekristos, H.T., K.P. Mlisane and Q. AbdelKarim,2005331772773Gottlieb, M.S., H.M. Schanker and A. Fan,19811981Goulder, P.J. and D.I. Watkins,20044630640Goulder, P.J.,20062006Hache, C. and J. Villeneure,2006718351843Haines, A.,200381855855Johnson, S. and J.G. Baraboutis,200028427222723King, E.J.,19511951Lee, W.M.,2003349474485Lott, J.A. and P.L. Wolf,19861986Martinez, E., J.L. Blanco, A. Amaiz, J.B.P. Cuevas and A. Mocroft et al.,20011512611268Perry, B.W., B.T. Doumas and D.D. Bayse,q198329297301Piliero, P.J. and B. Purdy,200111379382Reed, J.C.,20017314319Reisler, R., S. Liou, J. Servoss, G. Robbins and D. Theodore et al.,20012001pp: 811Reitman, S. and S. Frankel,1957285663Ringer, D.H. and L. Dabich,19791979105-116105-116Schambelan, M., C. Benson and A. Carr,200293032Schreiber, M.,20042004Speech, H.J. and H. Liehr,1983218996Sulkwoski, M.S., D.L. Thomas, R.E. Chaisson and R.D. Moore,20002837480Umar, R.A., M.J. Ladan, S.W. Hassan, Y. Saidu, A.Y. Abbas and I.B. Oduolisaeme,2007Lamivudine, Nevirapine and Stavudine) has no untoward effect on haematological profile in albino rats.]]>2147151Walensky, R.P., A.D. Paltiei and E. Casina,20061941119Whicher, J., R.F. Ritchie and A.M. Johnson,199440934938Wolf, L.D.,20032003WHO,20052005Wright, P.J. and D.T. Plummer,1974126568Yun, O.H., R.A. Okerholm and F.P. Guengerich,199321403409