Asian Journal of Biochemistry1815-99231815-9931Academic Journals Inc.10.3923/ajb.2007.84.100ThakurA. TiwariB.K. ThakurM. ThakurS. PandeyN.D. NarviS.S. 2200722The study describes SAR and QSAR of inhibition of Reverse Transcriptase-1 by HEPT derivatives using both classical and non-conventional physicochemical parameters along with hydrophobic parameter and indicator parameters. The set of HEPT derivatives Studied contains 85 compounds with different substitution at various positions. Application of multiple linear regression analysis indicated that combination of classical physicochemical parameters with indicator parameters yielded statistically significant model for modeling inhibitory activity (log1/C) against Reverse Transcriptase-1. Final selection of the potential HEPT derivative for the inhibition of Reverse Transcriptase-1 is made with the help of molecular modeling parameters.]]>Agrawal, V.K., R. Sohgaura, P.V. Khadikar and A. Phadnis,2001932953299Balaban, A.T., P.V. Khadikar, C.T. Supuran, T. Abhilash and T. Mamta,20051739663973Chaterjee, S., A.S. Hadi and B. Price,20003rd Edn.Clercq, D.E.,19958200239Hannongbua, S., L. Lawtrakul and J. Limtrakul,199610145152Hannongbua, S., L. Lawtrakul, C.A. Sotriffer and B.M. Rode,199615389394Hannongbua, S., S. Saen-oon, P. Pungpo and P. Wolschann,200113211571169Hyperchem,20072007Khadikar, P.V., K.C. Mathuhr, S. Singh, A. Phadnis, A. Shrivastava and M. Mandloi,20021017611766Khadikar, P.V., S. Karmarker, S. Singh and A. Shrivastava,20021031633170Kireev, D.B., J.R. Chretien, D.S. Grierson and C. Monneret,19974042574264Thakur, A., T. Mamta and P.V. Khadikar,20031152035207Thakur, A., T. Mamta and S. Vishwakarma,20041212091214Thakur, A., T. Mamta, K. Nitika, J. Ashok and G. Ashok,2004103643Thakur, A., A. Agrawal, M. Thakur and S. Thakur,200421723Thakur, M., T. Abhilash and V. Khadikar Padmakar,20041222872293Thakur, M., T. Abhilash and V. Khadikar Padmakar,200412825831Thakur, A.,2005144953Thakur, M., A. Thakur, P.V. Khadikar and C.T. Supuran,200515203209Young, S.D.,19931181192