Asian Journal of Biochemistry1815-99231815-9931Academic Journals Inc.10.3923/ajb.2006.224.235BashtarA. AhmedS.A. SolimanA.M. HamedM.A. 3200613This study has been carried out to investigate the most important aspects of metabolic integration between Schistosoma parasite and its final host under the influence of immunization with S. mansoni antigens. The possible side-effects of soluble worm antigen preparation (SWAP) and soluble egg antigens (SEA) were investigated through estimation of succinate dehydrogenase, lactate dehydrogenase, glucose-6-phosphatase, acid phosphatase and 5`-nucleotidase enzymes activities in hepatocytes of mice. Further, liver function enzymes as aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase were estimated. Cells viability, no of worm burden and ova count were also investigated. 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