Marcia Renata Mortari
Department of Biology, Neurobiology and Venoms Laboratory, Faculty of Philosophy, Sciences and Literature of Ribeido Preto, University of Sao Paulo, Brazil
Alexandra Olimpio Siqueira Cunha
Department of Biology, Neurobiology and Venoms Laboratory, Faculty of Philosophy, Sciences and Literature of Ribeido Preto, University of Sao Paulo, Brazil
Luciana de Oliveira
Department of Biology, Neurobiology and Venoms Laboratory, Faculty of Philosophy, Sciences and Literature of Ribeido Preto, University of Sao Paulo, Brazil
Erica Aparecida Gelfuso
Department of Biology, Neurobiology and Venoms Laboratory, Faculty of Philosophy, Sciences and Literature of Ribeido Preto, University of Sao Paulo, Brazil
Eveline Bis Vieira
Department of Biology, Neurobiology and Venoms Laboratory, Faculty of Philosophy, Sciences and Literature of Ribeido Preto, University of Sao Paulo, Brazil
Wagner Ferreira dos Santos
Av Bandeirantes, 3000, FFCLRP-Departamento de Biologia,
Ribeirao Freta, S P.l4040-090, Brazil
ABSTRACT
In this study we have investigated hemolytic, edematogenic and neurotoxic effects of the crude venoms of three Polybia species; P. occidentalis, P. paulista and P. ignobilis. In addition, protein contents and dry weights of these wasp`s venom reservoirs have also been compared. P. ignobilis presented the highest protein content and highest dry weight per venom reservoir. When injected in the hind paw of rats relatively to the other two, it evoked a stronger edematogenic effect. The venom of P. paulista showed the most potent hemolytic activity on human washed red blood cells. When tested on the erythrocytes of different species (rat, pigeon, ox, sheep, snake and horse), the three venoms showed marked differences in hemolytic activity according to the blood species. However, this variability appeared to be similar for the three venoms. Moreover, the intracerebroventricular injection of each of all three venoms caused tonic clonic seizures and death to rats. Present data suggest that although the three species are closely phylogenetic related, there must be pharmacological differences among the venom compounds that should be better investigated.
PDF References Citation
How to cite this article
Marcia Renata Mortari, Alexandra Olimpio Siqueira Cunha, Luciana de Oliveira, Erica Aparecida Gelfuso, Eveline Bis Vieira and Wagner Ferreira dos Santos, 2005. Comparative Toxic Effects of the Venoms from Three Wasp Species of the Genus Polybia (Hymenoptera, Vespidae). Journal of Biological Sciences, 5: 449-454.
DOI: 10.3923/jbs.2005.449.454
URL: https://scialert.net/abstract/?doi=jbs.2005.449.454
DOI: 10.3923/jbs.2005.449.454
URL: https://scialert.net/abstract/?doi=jbs.2005.449.454
REFERENCES
- Mendes, M.A., B.M. Souza., M.R. Marques and M.S. Palma, 2004. Structural characterization of novel chemotatic and mastoparan peptides from the venom of the social wasp Agelaia pallipes pallipes by high-performance liquid chromatography/eletrospray ionization tandem mass spectrometry. Rapid Commun. Mass Spectrometry, 18: 636-642.
- Geraud-Pouey, F., D.T. Chirinos, M. Pena and S. Arcila, 1998. Artropodos asociados com el cultivo del melon en la zona noroccidental de Venezuela. Rev. Fac. Agron., 15: 11-22.
Direct Link - Beleboni, R.O., A.B. Pizzo, A.C.K. Fontana, R.O.G. Carolino, J. Coutinho-Netto and W.F. Santos, 2004. Spider and wasp neurotoxins: Pharmacological and biochemical aspects. Eur. J. Pharmacol., 493: 1-17.
CrossRef - Bernheimer, A.W., L.S. Avigad, J.O. Schimidt and J.S. Ishay, 1982. Proteins in venoms of two wasps, Polistes comanchus navajoe and Vespa orientalis. Comp. Biochem. Physiol. C, 71: 203-207.
PubMed