Omage Kingsley
Department of Biochemistry, Igbinedion University, Okada, Edo State, Nigeria
Erifeta O. Georgina
Department of Biochemistry, Igbinedion University, Okada, Edo State, Nigeria
Josiah J. Sunday
Department of Biochemistry, Igbinedion University, Okada, Edo State, Nigeria
Uhunmwangho S. Esosa
Department of Biochemistry, Igbinedion University, Okada, Edo State, Nigeria
Nwangwu C. Spencer
Department of Biochemistry, Igbinedion University, Okada, Edo State, Nigeria
Njoya K. Helen
Department of Biochemistry, Igbinedion University, Okada, Edo State, Nigeria
Asuk A. Agbor
Department of Biochemistry, Igbinedion University, Okada, Edo State, Nigeria
ABSTRACT
The effects of Acalypha wilkesiana leaves on serum ALT and AST activities and body weight of normal rabbits were investigated. Oral administration of the leaf, in the form of decoction prepared by mixing 5 g of air-dried powdered leaves in 10 ml distilled water, at a dose of 1 g/kg body weight for a period of 8 and 15 days, caused a significant increase (p<0.05) in the activities of serum ALT and a significant decrease (p<0.05) in AST activities in normal rabbits. The treatment also led to a significant reduction (p<0.05) on the body weight of the experimental animals. This effect of the plant is a reflection of the relative safety of the plant in the management of hypertension and its possible use as a weight reduction therapy.
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How to cite this article
Omage Kingsley, Erifeta O. Georgina, Josiah J. Sunday, Uhunmwangho S. Esosa, Nwangwu C. Spencer, Njoya K. Helen and Asuk A. Agbor, 2011. Effect of Acalypha wilkesiana on Activities of Some Liver Function Enzymes and Body Weight of Normal Rabbits. Pakistan Journal of Nutrition, 10: 552-554.
DOI: 10.3923/pjn.2011.552.554
URL: https://scialert.net/abstract/?doi=pjn.2011.552.554
DOI: 10.3923/pjn.2011.552.554
URL: https://scialert.net/abstract/?doi=pjn.2011.552.554
REFERENCES
- Adesina, S.K., O. Idowu, A.O. Ogundaini, H. Oladimeji, T.A. Olugbade, G.O. Onawunmi and M. Pais, 2000. Antimicrobial constituents of the leaves of Acalypha wilkesiana and Acalypha hispida. Phytother. Res., 14: 371-374.
Direct Link - Oladunmoye, M.K., 2006. Comparative evaluation of antimicrobial activities and phytochemical screening of two varieties of Acalypha wilkesiana. Trends Applied Sci. Res., 1: 538-541.
CrossRefDirect Link - Giboney, P.T., 2005. Mildly elevated liver transaminase levels in the asymptomatic patient. Am. Family Physician, 71: 1105-1110.
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