Malnutrition and inflammation
are common in hemodialysis patients, and are usually closely associated.
Serum C-reactive protein (CRP) concentrations have been found to be
significantly elevated in hemodialysis patients and reflects chronic
inflammation, and as an acute-phase reactant, is a sensitive and independent
marker of malnutrition. To investigate the association of serum CRP
level with some nutritional variables in diabetic and non diabetic end-stage
renal failure patients undergoing regular hemodialysis, we designed
a study of 36 maintenance hemodialysis patients (f = 15 m = 21), consisting
of 25 non-diabetic HD patients and 11 diabetic HD patients. In this
study we found a near significant difference of CRP between diabetic
and non-diabetics of total patients with more values of CRP in diabetics,
a significant difference of CRP between diabetic and non-diabetic of
female HD patients with more values in diabetics and a significant difference
of CRP between males and female of non-diabetic population with more
values of CRP in males. An inverse correlation of serum CRP with serum
cholesterol and triglyceride levels and a near significant positive
correlations of CRP with serum ALP and with serum iPTH were found. An
inverse correlation of serum CRP with dialysis efficacy was seen too.
No significant association between serum CRP and serum albumin was seen.
Compatible with some studies and in contrast to some other studies,
the association of serum albumin with serum CRP levels in this study
was insignificant. The positive correlation of high serum PTH with inflammation
implies further need to control of hyperphosphatemia and secondary hyperparathyroidism
in HD patients, also inverse correlation of serum CRP with cholesterol
and triglyceride further support the malnutrition-inflammation complex
syndrome (MICS) which frequently seen in HD patients.