Comparing Analgesic Effects of a Topical Herbal Mixed Medicine with Salicylate in Patients with Knee Osteoarthritis
Mohammad Reza Vafaeenasab
Knee osteoarthritis is the most common cause of disability among people and it is a common disease of joints that can lead to cartilage damage. In this study the analgesic effects of a herbal ointment containing cinnamon, ginger, mastic (Saghez) and sesame oil is compared with Salicylate ointment in patients suffering from knee osteoarthritis. It was a double-blind randomized controlled trail study. Patients with diagnosed arthritis were involved in the study and they were divided in two groups via block randomization method. For six weeks, twice a day, intervention group applied herbal ointment and control group used Salicylate ointment. The severity of pain, morning stiffness and limited motion were measured using Visual Analog Pain Scale. In order to analyze the trends of these three indexes, repeated measurement test was used. Ninety two participates with the mean age of 52.2 (±12.4) years and with the mean disease period of 30.45 (±30.3) months were involved in the study. There was no significant difference between two groups regarding the distribution of sex, weight, height, BMI and the duration of illness. No statistical difference was observed between two groups regarding pain relief, morning stiffness and limited motion; nevertheless in repeated measurements during second, forth and sixth weeks in both groups the decreasing trend of these three indexes had been statistically significant (p<0.0001). It seems that using this herbal combination is clinically effective for patients suffering from knee osteoarthritis in order to decrease their pain, morning stiffness and limited motion; its effect is comparable with Salicylate ointment.
July 30, 2011; Accepted: October 14, 2011;
Published: November 19, 2011
Osteoarthritis is one of the most common debilitating diseases which usually
involves joints and damages cartilage (Felson, 1993;
Creamer et al., 1998; Gemmell
et al., 2003; Martel-Pelletier et al.,
2008). It influences knees more than any other joints and about 80% of people
older than 65 years old are usually affected by the disease (Creamer
and Hochberg, 1997; Gemmell et al., 2003).
The symptoms of knee osteoarthritis are pain, morning stiffness and knee limited
motion (Hochberg et al., 1995). In the past few
years there has not been much progress in treating the disease and it has been
limited to some analgesic anti-inflammatory drugs (Hungin
and Kean, 2001; Petrella et al., 2002). There
are various curing methods including oral medicines, topical drugs, intra-joint
drugs, complementary drugs and surgery (Buffum and Buffum,
2000; Miller et al., 2005; Ameye
and Chee, 2006; Altman, 2009) nonetheless nonsteroidal
anti-inflammatory drugs are extensively used for treatment (Buffum
and Buffum, 2000; Hungin and Kean, 2001). It has
been recommended to use the topical form of these medicines as they do not have
the side effects of systemic drugs (Roth and Shainhouse,
2004; Altman, 2009). Salicylate ointment is a common
topical medicine prescribed for this disease however one of the problems in
using this ointment is that it cannot deeply penetrate skin (Hungin
and Kean, 2001; Altman, 2009).
Herbal medicines could be used to relief pain (WHO, 1998)
and there have been some new researches about applying herbal medicines for
treating osteoarthritis (Teekachunhatean et al.,
2004). Some studies showed that using herbal combinations could be effective
and could have fewer side effects; these drugs are very prevalent and popular
in some countries (Teekachunhatean et al., 2004).
Cinnamon essence which has analgesic and anti-rheumatic effects could inhibit
IL-1 beta and IL-6 (Montes-Belmont and Carvajal, 1998;
Chao et al., 2005). Ginger is one of the most
famous herbal drugs and is traditionally prescribed for headaches and rheumatic
pains (Haghighi et al., 2003). It seems that
ginger could have pharmacologic effects similar to nonsteroidal anti-inflammatory
drugs and it could prevent generating prostaglandin via controlling cyclooxygenase
1 and 2 (Grzanna et al., 2005; Shen
et al., 2005). Some other studies showed that mastic is another strong
analgesic material as well (Gulcin et al., 2003).
As effective herbal medicine are cheaper and less harmful they more accepted by patients and finding efficient analgesic herbs could be greatly beneficial in medicine. This study investigated the analgesic effects of an herbal combination of ginger, mastic and sesame oil as a topical medicine compared with Salicylate in patients affected by knee osteoarthritis.
MATERIALS AND METHODS
This is a double-blind randomized controlled trail study conducted among patients with osteoarthritis in knee joints. Considering confidence limits of 95%, power of 80% and trying to achieve the least significant statistical difference equal to 15 mm of pain relief (±22) based of Visual analog scale (VAS), the sample size was calculated as 39 people for each group; in our study 46 people were included. Patients signed printed consent forms and collected data were kept confidential. Patients were allowed to take acetaminophen in case of severe pain.
The participants were divided into two groups of placebo and intervention group via block randomization.
Inclusion criteria were diagnosing osteoarthritis by a orthopedic specialist, pain score higher than 30 mm and stability in taking medication within two last weeks. Exclusion criteria were applying any topical medicine for knee within last month, wounds in knee, intra-joint injection or taking corticosteroid drugs within three last months, surgery on knee, having knee problem other than osteoarthritis and physiotherapy within last month or during the study. If both knees were involved, the knee with more pain have had been assessed and in case of equal pain, the knee of dominant leg have had been considered. Randomization was done by a trained nurse. Totally 115 people were assessed from which 23 persons did not fulfilled inclusion criteria. Nobody left the study within initial four weeks, however during forth to sixth week, one person in placebo group and three persons in intervention group were excluded; from those who left, two persons did not referred back on time even after follow-up and one other person stopped taking the drug during the study (Fig. 1).
Patients took two grams (a knuckle) of topical ointment three times a day and
massaged it over the knee for one minute for six weeks. Patients got no recommendation
about changing their sport habits or limited motion but they were advised to
prevent over-pressures on knees.
|| State of randomization of participants in the study
Pain severity, morning stiffness and nightly pains were measured by VAS with
a 100 mm scale, starting from zero (without pain or without morning stiffness,
or without limited motion) and ending to 100 (maximum pain, maximum morning
stiffness, or maximum limited motion); patients were trained about VAS before
answering the questions. In each referral, patients were asked about the amount
of pain while walking during last 24 h.
Changing trends of pain, morning stiffness and limited motion were assessed using repeated measurement and taking sedatives and disease length were considered as covariates. Then, once sphericity assumption was rejected, their average p-values were reported through adjusting degree of freedom by correction coefficients of Greenhouse-Gisser and Huynh-Feldt. SPSS 11.5 was used for statistical analysis.
In this study, 92 people were assessed and 46 people were in each group; after sixth week, three persons in Salicylate group and 4 persons in herbal pomade did not referred back. Both groups were similar in sex and side of affected knee. Age mean of all participants was 52.2 (±12.4) years and there was no significant difference between two groups. The mean duration of illness, height, weight and BMI were 30.45 (±30.3) years, 159.3 (±7.1) centimeters, 71.2 (±12) kg and 28.1 (±4.6) Kg m-2 and there was no significant statistical difference in these variables between two groups (Table 1).
In both groups of patients taking herbal and salicylate ointment after starting
interventions the changing trend of pain became falling and in both groups the
observed difference in pain severity in second, fourth and sixth week had significant
statistical difference with the time before intervention (p = 0.0001). Nevertheless,
the trends of changes in two groups of patients did not have significant statistical
difference after controlling variables of disease duration and taking acetaminophen
analgesics (F (3, 1.479) = 0.974; p = 0.358; r = 0.245) (Table
The trend of changes in morning stiffness after interventions was falling in both groups too and the observed difference between two groups in morning stiffness after and before interventions was statistically significant (p=0.0001). Nonetheless, the trends of changes in two groups did not have significant statistical difference after controlling variables of disease length and taking acetaminophen analgesics (F (3, 1.649) = 0.418; p = 0.62; r= 0.35) (Table 2).
||Comparing the characteristics of two groups receiving herbal
medicine and Salicylate
|Data was analyzed using chi square
In addition, changes in limited motion during second, fourth and sixth weeks were falling in both groups too and the observed difference between two groups in limited motion after and before interventions was statistically significant (p = 0.0001).The trend of changes in two groups of patients did not have significant statistical difference after controlling variables of disease length and taking acetaminophen analgesics (F (3, 1.583) = 1.037; p = 0.343; r = 0.51) (Table 2).
In this study, the mean of age, the duration of disease, height, weight, BMI, gender distribution, type of knee and daily sedative dosage were similar in both groups. Based on the results, morning stiffness, pain and limited motion had more reduction in herbal ointment group in second, fourth and sixth week, however this difference was not statistically significant. While analyzing the trends of changes, the reduction of these treatment indexes in repeated measures in second, forth and sixth week was statistically significant in both groups. Therefore we can say the herbal ointment could have an outcome at least equal to Salicylate in management the symptoms of knee osteoarthritis.
The effects of Nonsteroidal anti-inflammatory drugs in management of osteoarthritis
are still controversial (Lin et al., 2004) and
unfortunately there are few studies about salicylate ointment. likely reasons
for inefficacy of salicylate ointment in some studies could have originated
from various variables, number of times it had been used and slight penetration
of medicine into skin (Shackel et al., 1997;
Cross et al., 1998).
Though few studies are conducted about herbs that are effective in management
of osteoarthritis, ginger is the most well known herb which its effects on osteoarthritis
had been studied and had been used for management of osteoarthritis and arthritis
rheumatoid. Probably, because of inhibiting Cyclooxygenases (COX) and Lipoxygenase,
ginger had anti-inflammatory effects (Gregory et al.,
2008). In Altman and Marcussen (2001) after six
weeks pain in knee had reduced 24.5 mm in oral ginger group and 16.4 mm in placebo
group; the difference was significant and no side effects had been observed.
|| Mean and standard deviation of pain, morning stiffness and
limited motion (visual analog scale) during the study in the two groups
However in Bliddal et al. (2000) ginger had
temporary analgesic effect. Haghighi et al. (2005)
showed that ginger was as effective as ibuprofen in relieving knee pain in osteoarthritis
and it could decrease pain as much as 30 mm but it did not reduced limited motion.
Cinnamon essence could alleviate pain and it could have anti-rheumatoid effects
as well (Montes-Belmont and Carvajal, 1998). Joshi
et al. (2010) proposed the likely anti-inflammatory effects of cinnamon
and suggested to conduct further researches about it. The anti-inflammatory
effects of cinnamon may be due to controlling IL-6 and IL-1 beta (Chao
et al., 2005). In this study, mastic and sesame oil were used as
a base for this herbal ointment; nonetheless, sesame oil could have great effects
on joints because it excessively contains oleic acid, linolenic acid and archidonic
acid and some anti oxidants (Kremer et al., 1990;
Linos et al., 1999).
Van Haselen and Fisher (2000) showed that homeopathic
herbal ointment is as effective as none-steroidal anti-inflammatory ointment
in decreasing osteoarthritis pain. There are still controversial and contrasting
results about the effects of herbal medicines for management osteoarthirit and
it is necessary to do further researches. One of the problems with these ointment
is their weak penetration into skin and joints; it is essential to add some
ingredients to increase penetrative capacity of ointment into joints. Another
method is to increase the effective herbal ingredients to make ointment with
It is suggested to do further researches with larger sample sizes and using higher doses of this herbal medicine. It may be helpful to add ingredients which increase ointment penetrative power. Also it is suggested to use effective components of this herbal medicine to make ointment. If possible, it would be a good idea to take some further researches about oral form of the drug.
Based on the results of this study, taking this herbal combination could have valuable clinical effects for pain relief, limited motion and especially morning stiffness among patients affected by osteoarthritis; in order to decrease the side effects of chemical ointments this herbal ointment can be utilized.
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