S. Z. Idid
Biomedicalscience Department, Faculty of Allied Health Sciences,
University Kebangsaan, Malaysia (UKM), Kuala Lumpur, Malaysia
D. M. Jalaluddin
Anatomy Department, Faculty of Medicine, UKM, Kuala Lumpur, Malaysia
B. H. Ridzwan
Biomedicalscience Department, Science Faculty, International Islamic University, Gombak, Malaysia
A. Bukhori
Pharmacy Department, Faculty of Allied Health Sciences, UKM, Kuala Lumpur, Malaysia
S. Nor Hazlinah
Biomedicalscience Department, Faculty of Allied Health Sciences,
University Kebangsaan, Malaysia (UKM), Kuala Lumpur, Malaysia
C. C. Hoo
Biomedicalscience Department, Faculty of Allied Health Sciences,
University Kebangsaan, Malaysia (UKM), Kuala Lumpur, Malaysia
L. K. Marthivarman
Biomedicalscience Department, Faculty of Allied Health Sciences,
University Kebangsaan, Malaysia (UKM), Kuala Lumpur, Malaysia
ABSTRACT
The pleurisy model in rats was used to study the pharmacology of extracts from the sea-cucumber Stichopus badionotus Selenka. Ten control animals were injected intrapleurally with 0.1ml carageenan (1%) and their pleural cavities were examined. Three groups (six animals per group) were treated with concentrations of 5, 10 and 20 mg/ml of the ethanol extract of sea-cucumber given i.p. and three other groups were treated with similar concentrations of a phosphate-buffer extract also given i.p. A half-hour later the animals were administered carageenan (i.p.). These animals were killed four-hours after the administration of carageenan and their pleural cavities were examined. The results showed that the extracts were able to reduce pleural effusion, neutrophil counts, and also adenosine deaminase activity significantly and in a dose-dependent manner. The effects were more pronounced with ethanol extract compared to the phosphate-buffer extract.
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How to cite this article
S. Z. Idid, D. M. Jalaluddin, B. H. Ridzwan, A. Bukhori, S. Nor Hazlinah, C. C. Hoo and L. K. Marthivarman, 2001. The Effect of Two Extracts from Stichopus badionotus Selenka upon Induced
Pleurisy in Rat. Pakistan Journal of Biological Sciences, 4: 1291-1293.
DOI: 10.3923/pjbs.2001.1291.1293
URL: https://scialert.net/abstract/?doi=pjbs.2001.1291.1293
DOI: 10.3923/pjbs.2001.1291.1293
URL: https://scialert.net/abstract/?doi=pjbs.2001.1291.1293
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