Functional Foods: Hopefulness to Good Health
Functional foods will be hopeful to good health in the future because it have been classified either as preventive or therapeutic purpose and used alone or mixed together for prevention some of certain diseases. Therefore, functional foods help the rights of protection from many modern diseases that we see today. However, increasing and varieties of the functional foods are a challenging perspective for promotion and formulation of healthy food and which can be useful for enhancements of the human health.
In light of the tremendous development in the technology industry and the competition
between nations to catch up with civilization and technology led to environmental
changes and change in human behavior and food habits and was surrounded by a
set of risks resulted from the environmental pollution or caused by excessive
use of agricultural techniques and pesticides and heavy metals pollution. The
interest in developing functional foods is thriving, driven largely by the market
potential for foods that can improve the health and well-being of consumers.
Historically, long-established food traditions and the knowledge of what foods
are and how they should be eaten have neutralized the food-related anxieties.
Nowadays, medical science, food science and nutrition have replaced those traditions
and set up new rules for our eating (Beardsworth and Keil,
Functional foods includes foods or food ingredients that exert a beneficial
effect on human health and/or reduce the risk of chronic disease beyond basic
nutritional functions (Huggett and Schliter, 1996).
For healthy growing and life, must daily diet contain a healthy functional
food ingredients. Consumers judge food products not only in terms of taste and
nutritional needs, but also in terms of the ability to improve their health
and well-being. Functional foods and functional food ingredients exert a beneficial
influence on body functions to help improve well-being and health and/or reduce
the risk of chronic diseases. Functional food can be produced by addition of
health-promoting component(s), by reducing/removing harmful components and/or
by modifying the nature or the bioavailability of specific components. On the
road to optimize nutrition that will be one of the major challenges of nutrition
in the twenty-first century, functional foods have their own role to play. But
the development of claims for already existing food products, as well as the
development of new products and their own claims, should remain first a scientific
challenge and not only a marketing challenge. This is the condition for success
to the benefit of both human health and the food industry (Verschuren,
There are indications for some beneficial effects of functional foods on the
developing immune response, for example induced by antioxidant vitamins, trace
elements, fatty acids, arginine, nucleotides and altered antigen contents in
infant foods. Peak bone mass at the end of adolescence can be increased by dietary
means, which is expected to be of long-term importance for the prevention of
osteoporosis at older ages (Koletzko et al., 1998).
This study is concerned with the trend towards the development of functional foods as a preventive or therapeutic purpose for prevention some of certain diseases and for promotion the human health in developed countries and related with food in the ancient world.
Definition of Functional Foods
Expanding knowledge of the role of physiologically active food components,
from both plant (phytochemicals) and animal (zoochemicals) sources, has notably
changed the role of diet in health. This led to the development of a new generation
of foods termed functional foods. These foods provide health benefits beyond
the basic nutrition needs (National Academy of Sciences, 1998).
The term Functional Foods was first introduced in Japan during the eights of
the last Century with the development of a special seal to denote Foods for
Specified Health Use (FOSHU) which refers to processed foods containing ingredients
that enhance specific body functions, in addition to being nutritious. FUFOSE
developed a working definition for a functional food as Food that satisfactorily
demonstrated to affect beneficially one or more target functions in the body,
beyond adequate nutritional effects, in a way that is relevant to either an
improved state of health and wellbeing and/or reduction of risk of disease.
In the context of this working definition, a target function is a specific biological
activity in the body targeted by the intervention to maintain or improve health,
well-being and/or reduction of risk of disease.
The American Dietetic Association (ADA) takes one of the most inclusive views
to define functional foods. The American Dietetic Association
(1999) described functional foods as any potentially healthful food or food
ingredient that may provide a health benefit beyond the traditional nutrients
it contains and also made the following very important points:
||Functional foods may be whole, fortified, enriched, or
||Its likely that all foods are functional at some physiological level
||To have a beneficial effect on health, a functional food should be consumed
as part of a varied diet on a regular basis, at effective levels
In the nineties, the European Commission (EC) funded an activity to establish a science-based approach to explore the concept of functional foods. This Concrete Action i.e., Functional Food Science in Europe (FUFOSE), involved a large number of European experts in nutrition and related sciences. The FUFOSE produced a consensus report that has become widely used as a basis for discussion and further evolution of thinking on the topic. A working definition of functional food has been developed by FUFOSE that a food that beneficially affects one or more target functions in the body beyond adequate nutritional effects in a way that is relevant to either an improved state of health and well-being and/or reduction of risk of disease.
The International Food Information Council (IFIC, 1998)
defines functional foods as foods that provide health benefits beyond basic
nutrition. The nutritional science evolved from identifying and correcting nutritional
deficiencies to design foods that promote optimal health and reduce the risk
of chronic disease. Focus group research showed that functional foods was recognized
readily and was preferred by consumers over other terms such as nutraceuticals
or designer foods (IFIC, 2002). This definition is similar
to that of the International Life Sciences Institute of North America (ILSI),
which has defined functional foods as foods that, by virtue of physiologically
active food components, provide health benefits beyond basic nutrition (ILSI,
The Food and Nutrition Board of the National Academy of Sciences described
a functional food as, any modified food or food ingredient that may provide
a health benefit beyond that of the traditional nutrients it contains (Food
and Nutrition Board,1994). A variety of terms have appeared world-wide such
as nutraceuticals, medifoods, vitafoods and the more traditional dietary supplements
and fortified foods. However, the term functional foods has become the predominant
one even though several organizations have attempted to differentiate this emerging
food category. Health Canada, for instance, defines a functional food as similar
in appearance to a conventional food, consumed as part of the usual diet, with
demonstrated physiological benefits and/or to reduce the risk of chronic disease
beyond basic nutritional functions and a nutraceutical as a product isolated
or purified from foods that is generally sold in medicinal forms not usually
associated with foods (Health Canada, 1998). In Korea,
functional foods are defined as dietary supplement whose purpose is to supplement
the normal diet and have to be marketed in measured doses, such as in pill,
tablets. However, functional foods are generally considered as those foods which
are intended to be consumed as part of the normal diet and that contain biologically
active components which offer the potential of enhanced health or reduced risk
Examples of Functional Foods
Functional foods include foods that contain specific minerals, vitamins,
fatty acids or dietary fibre, foods with added biologically active substances
such as phytochemicals or other antioxidants and probiotics that have beneficial
effects on life. According to this definition, unmodified whole foods such as
fruits and vegetables may be considered as the simplest form of a functional
food. For example, broccoli, carrots, or tomatoes would be considered functional
foods because they are rich in physiologically active components such as sulforaphane,
β-carotene and lycopene, respectively. Also, modified foods, including
those that have been fortified with nutrients or enhanced with phytochemicals
or botanicals fall within the realm of functional foods. In addition, food biotechnology
will continue to provide new venues for functional food development. Table
1 show examples of some functional foods and their potential health benefits
(American Dietetic Association, 1999; Mazza,
1998; Wildman, 2001).
Functional Foods and the Ancient Civilizations
Wheat has been used as a food grain since the last Stone Age. It can be
considered the oldest domesticated crop grown for food-dating from 8,000-10,000
B.C. In fact, the ancient civilizations such as Egyptian, Babylonian, Greek,
Cretan and Roman were highly dependent on wheat and barley as the principal
food. Einkorn, Emmer, Khorasan/Kamut and Spelt are among the earliest cultivated
wheat and are commonly referred to as ancient wheat. Some of the oldest and
most complete written records about the use of herbs as supplements were recorded
thousands of years ago in Egyptian hieroglyphics. The most famous of these writings
is known as the Papyus Ebers, which note the medicinal uses of over 700 herbs
and plants. Many of the herbs recorded in this document back in 1500 B.C. are
still in use today, aloe vera being one well-known example.
The Egyptians buried their Pharaohs with all kinds of earthly belongings. Three
thousand-year-old seed corn found in Egyptian tombs was made to sprout and grow.
There are still many tombs that might be discovered to shed more information
on this topic. More writings and possibly some preserved herbal remedies could
one day be exhumed. One interesting discovery is that ultrasound tests indicate
there is a hidden room in the ground underneath the great sphinx. Cereal foods
formed the main backbone of their diet from the predynastic period onward. Even
for the rich, this staple mean generally consisted of a variety of different
breads and barley often with other ingredients mixed. Also, ancient Egyptians
ate vegetables, fruit and fish. They often ate beans, chick peas, lentils and
green peas, just as modern Egyptians do today. Leeks and Egyptian lettuce was
also popular. garlic were eaten, as well as thought to repel agents of diseases
and onions were popular, as well as being used for medical purposes. The most
popular fruit in ancient Egypt was probably dates of palm, which are rich in
sugar and protein. They used the honey as a sweetener. While milk, cheese and
butter are not well attested to, at least in text, we certainly believe that
the early Egyptians were familiar with all of these dairy products. We do find
a number of scenes showing men carrying what appears to be pots of milk or cream
and in one Theban tomb from the 19th dynasty, we find a seated woman pulling
white cones of what is probably butter or cheese out of a large vessel (Ian,
2000; Eugen, 1992).
The basic food of Sumerian diets were of barley and wheat cakes as the staple
diet together with grain and legume soups, onion, leeks, garlic and melon. Besides
farmed vegetables, Sumerian food also included fruits. These were apples, fig
and grapes. Several culinary herbs and honey and cheese, butter and vegetable
oil have also been mentioned in later Sumerian food records (Tannahill,
In the first century AD, the Greek physician Dioscorides made a thorough record
of the medicinal uses of over 500 herbs and plants. This record, named De Materia
Medica, informed and influenced herbalists for centuries afterward. Pedanius
Dioscorides was an ancient Greek physician, pharmacologist and botanist from
Anazarbus, Cilicia, Asia Minor, who practiced in ancient Rome during the time
of Nero. He had the opportunity to travel extensively seeking medicinal substances
from all over the Roman and Greek world. Dioscorides is famous for writing a
five-volume book in his native Greek that is a precursor to all modern pharmacopeias
and is one of the most influential herbal books in history. In fact it remained
in use until about CE 1600. Unlike many classical authors, his works were not
rediscovered in the Renaissance, because his book never left circulation (Gunther,
Bread accompanies all meals. It is great variety of foods were available in
ancient Greece. They consumed small amounts of mainly simple dishes such as
the Melan Zomos (black broth)-a hearty, thick, meatless soup possibly made with
special varieties of black chick peas (-or other legumes and vegetables. Bread,
olive oil and other foods that are derived from hunting, fishing or simple gathering
become basic and necessary products in the Greek diet (Zouraris,
Pepper appears in medical and literary writers from the fourth century BC to
the cookery book of Apicius in late antiquity. The spice was valued both as
a flavour and for its heating qualities in medicine. Ginger was a key import
from distant lands. The Greeks used incense and myrrh from an early date; pepper
and other strong flavours with pharmacological applications were the first mentioned
in Hippocrates; imports seem to have developed apace after the time of Alexander
through to the Roman imperial period (Miller, 1969).
Herbal remedies were widely used in the Roman Empire, including crushed mint leaves, basil, oregano and mandrake herb. Other early uses of plants in Rome were for the poisoning of political opponents and for antidotes to poisons. Wheat is the main ingredient in bread, which, along with circuses, the public of Rome clamored for, according to Juvenal. Also, Garum was a Roman fish sauce.
An ancient Babylonian burial site that was discovered by archeologists contained various preserved medicinal herbs, including marshmallow root. These are thought to be some 60,000 (or 6000) years old and are the oldest intact examples of herbal remedies. In ancient cultures, people were often buried with treasures and items that would help them in the after life. In later eras, Babylonians recorded their medical uses for herbs onto clay tablets in cuneiform writing. Tablets have been found dating from around 2600 B.C. that record the uses for honey, poppy juice, essential oil of cypress and cedar, myrrh, licorice and other remedies which today are used every day by people all around the world.
Functional properties of barley was used in ancient Arab as a protective and therapeutic food. They have formulated from barley the Talbina. It is a meal made from satoo, formed by adding milk and honey to the dried barley powder. They reported Talbina could to be very nutritious, beneficial in coughs and inflammation of the stomach and to have the ability to expel toxins from the body and act as a good diuretic. It gives rest to the heart of the patient and makes it active and relieves some of his sorrow and grief (Ibn al-Qayyim Aljouzi in 1292-1350CE; Ibn Khaldun, 1867).
Chinese medicine is famous for its extensive use of herbs and plants. For over
five thousand years, Chinese herbalists have used ginkgo biloba tree leaves,
ginseng roots, Cordyceps mushrooms, teas and many other herbs and health tonics
to support good health. The Chinese have been treating illnesses and disease
with functional ingredients of herbs as far back as the 3rd century BC; the
same tradition is widely used today. Herbal medicine is based on the theory
of Yin and Yang where everything has an equal, for example for good there is
bad, light there is dark. This theory correlates to the body in that elements
in the body are out of harmony and body may lack vitality. Chinese herbal medicines
are mainly plant based, but some preparations include minerals or animal products.
They can be packaged as powders, pastes, lotions or tablets, depending on the
herb and its intended use. Different herbs have different properties and can
balance particular parts of the body. Prescribing a particular herb or concoction
of herbs means the practitioners diagnosis has to take into account the
state of the patients Yin and Yang and the elements that are governing
the affected organs. Chinese herbal remedies are made up of one or two herbs
that are said to have the greatest effect on major aspects of the problem being
treated. The other herbs in the formula treat minor aspects of the problem,
direct the formula to specific parts of the body and help the other herbs work
more efficiently (Wright, 2004).
Recently, there has been a shift in universal trend from synthetic to herbal
medicine, which we can say Return to Nature. Medicinal plants have been known
for millennia and are highly esteemed all over the world as a rich source of
therapeutic agents for the prevention of diseases and ailments. Countries with
ancient civilizations are still using several plant remedies for various conditions.
The demand for plant based medicines, health products, pharmaceuticals, food
supplement, cosmetics etc are increasing in both developing and developed countries,
due to the growing recognition that the natural products are non-toxic, have
less side effects and easily available at affordable prices (Kalia,
Functional Foods and Health
Food has long been associated with health. Every individual requires, roughly,
the right combination of foodstuffs at the right time and in the right amounts
in order to maintain health and enjoy broader human flourishing. Functional
foods could potentially be used for improved health or well-being in a range
of areas, including cardiovascular system, gastro-intestines, growth, metabolism,
defense against free radical oxidation and to enhance psychological functions.
Although safety issues are paramount in food production and nutrition, functional
foods differ from more traditional products, as they also raise issues of efficacy.
Whilst the avoidance of food-borne pathogens, allergens and toxins is an issue
for all foods, the achievement of a health or well-being benefit is not. Usually
this benefit is restricted to drugs for which stringent efficacy tests apply
There are a wide range of products and developments that provide examples for
the changing relationship between food and health because of the increasing
attention to the health-diet interaction. The idea that food habits have direct
influence on one's health is certainly not new, but the attention paid to this
relation is increasing. Ongoing research yields new insights regarding the relation
between food habits and the increase or decrease of the incidence of varies
aliments, such as certain types of cancer and different forms of cardiovascular
diseases. These scientific developments have not only resulted in extensive
literature on the impact of food habits on health, but also in practical dietary
advice. The daily recommended intake of 200 g vegetables and 2 pieces of fruit
is a good example of an effective guideline to decrease the risk of these ailments.
On the other hand, there is an increased attention to the health-diet interaction
as a result of the combination of enough safe but unhealthy food in the Western
world and lifestyle habits of many individuals which resulted, for example,
in the problem of obesity. In spite of the clear and practical general dietary
advices, compliance rates are very low and even if they are followed, they are
often combined with all kinds of other unhealthy (food) habits. The epidemic
character of obesity has alarmed different groups and organizations within society
all over the World and has resulted in a strongly increased awareness of the
health aspect of food products and dietary patterns (Meijboom,
2007; WHO, 1998; Astrup, 2004).
Preparation and evaluation of formulated functional cheese cake and yoghurt
cake for diabetics to assess benefits on health have been studied by Abdel-Salam
and Ahmed (2007) and Abdel-Salam et al. (2009a).
The obtained data showed that formulated functional cheese cake with fructose,
whole wheat, egg white, skimmed milk, kareesh cheese and olive oil or yoghurt-cake
containing hot water extract of stevia, whole wheat flour, egg white, skimmed
milk, yoghurt, orange peels, lemon rind and olive oil would be a great meal
replacement diet for diabetics.
Many studies have highlighted the food in relation to the publics health.
For example, Meijboom (2007) focused on the nature and
importance of trust as a value in relation to food issues. Trust is a social
value: it can only exist where people relate to each other in an appropriate
way within the context of some form of social grouping, such as a community
or population. Meijboom (2007) explored the difficulties
of information provision in relation to functional foods and personalized diets
and argues that the complexity of such information means that trust is more
important in relation to food than it has ever been. Doris Schroeder also focuses
on recent technological developments through a discussion of a set of issues
relating to so-called functional foods: that is food that seeks to perform an
additional role beyond the mere nutritional, such as enhancing health, delivering
medicines, or preventing disease (Dawson, 2007).
Few other aspects of food supply and metabolism are of greater biological importance than the feeding of mothers during pregnancy and lactation and of their infants and young children. Nutritional factors during early development not only have short-term effects on growth, body composition and body functions but also exert long-term effects on health, disease and mortality risks in adulthood, as well as development of neural functions and behaviour, a phenomenon called metabolic programming. The evaluation of dietary effects on child growth requires epidemiological and field studies as well as evaluation of specific cell and tissue growth. Novel substrates, growth factors and conditionally essential nutrients (e.g., growth factors, amino acids, polyunsaturated fatty acids) may be potentially useful as ingredients in functional foods and need to be assessed carefully. Intestinal growth, maturation and adaptation as well as long-term function may be influenced by food ingredients such as oligosaccharides, gangliosides, high-molecular-mass glycoproteins, bile salt-activated lipase, pre- and probiotics.
Functional Dairy Products and its Beneficial Effect on Human Health
Milk as a nutritional food has recently been the topic of research and discussion
related to weight management. In fact, consumption of dairy products has been
linked to several health benefits that are the direct antitheses of diseases
and complications that arise from overweight and obesity. For example, individuals
that consume low-fat dairy products are more likely to have lower weight (Zemel,
2004), lower blood pressure (Moore et al., 2005;
Vollmer et al., 2001) and decreased risk of stroke
(Abbott et al., 1996), colon cancer (Kampman
et al., 2000; Holt, 1999) and osteoporosis
(Mccabe et al., 2004; Savaiano,
2003; Zemel, 2002). Heaney et
al. (2002) re-examined calcium-related blood pressure and bone studies
and reported a strong relationship between dairy consumption and weight reduction.
Protein components in milk provide high branched chain amino acid content which
help to maintain lean muscle tissue. Several components found in skim milk may
have a protective effect against the onset of disease that occurs as a result
of obesity. Many of the components found in skim milk can be isolated and used
in specific applications for individuals that do not consume dairy or may be
lactose intolerant (Dangin et al., 2001; Layman,
2003; Layman and Baum, 2004).
Another study concluded that lipid peroxidation induced by lead can be counteracted
by ingestion of Capparis, Artemisia and whey proteins (Abdel-Salam
et al., 2009b).
Mixtures of probiotics and prebiotics, which favourably modify the gut flora and its metabolism by increasing the survival of health-promoting bacteria, are described as synbiotics. The major applications for probiotics are in dairy foods while prebiotics are added to dairy products, table spreads, baked goods and breads, breakfast cereals and bars, salad dressings, meat products and some confectionery items.
Abdel-Salam et al. (2008) showed that probiotic
labneh containing garlic and onion oil demonstrated a protective effect and
reduced the total worm couple, male and female as well as, ova in liver and
intestine in mice infected with S. mansoni. Also, probiotic labneh containing
garlic or onion oil increased the dead oogram in mice infected with S. mansoni.
It can be concluded that probiotic labneh containing garlic and onion oil may
be play a great role as a protective food against infectious diseases such as
Schistosomiasis. Also, another study investigated the biological effects of
aqueous herbal extracts (aqueous extracts of fenugreek, greater burdock, goat's
rue, colocynth, chicory and lupine) mixed with stirred yoghurt filtrate against
alloxan-induced oxidative stress and diabetes in rats and concluded that mixture
of medicinal plant extracts and stirred yoghurt filtrate may play a role in
protection against alloxan-induced oxidative stress and diabetes in rats (Al-wabel
et al., 2008). Probiotic yoghurt displays an immunmoprophylactic effect
by stimulating plasma immunoglobulin response, which improved the liver and
spleen weight to be nearest to the control. In addition, the activities of aspartate
transaminase (AST), lactate dehydrogenase (LDH) and g-glutamyl transferase (gGT)
were significantly increased in the infected group compared to the control (Ghanem
et al., 2005).
The biological evaluation of a symbiotic fermented milk synergistic with some
active ingredients of herbal and honey on the sexual activity, semen characteristics
and testosterone levels in Ardhi and Damascus goat's bucks have been studied
by Al-Sobayil et al. (2008). Results showed that
giving goat bucks a mixture of a synbiotic functional syrup enhanced the metabolic
activity resulting in improvements in their reproductive performance. The antibacterial
effect of labneh containing aqueous extracts of oregano, marjoram, sage and
licorice against E. coli and B. subtilis were demonstrated an
inhibitory effect against both organisms (Al-Turki et
al., 2008). Probiotic fermented milk containing honey, garlic, ginseng,
cod liver oil and chicory was enhanced the role of protection against lead acetate
contamination in rats by increasing the activity of the antioxidant enzymes
that requires the antioxidant glutathione as substrate, thus protecting the
liver against the oxidative damage (Al-Wabel et al.,
Supplementing or administering specific ingredients in hydrolysate form with
beneficial probiotic bacteria to ruminant animals were a promising area of a
study reported by Al-Sobayil et al. (2010). This
was evident as to promote the foetal growth and enhance the secretory activity
of the corpus luteum in Najdi ewes. They concluded that, the administration
of a synbiotic formula to oestrous-synchronized Najdi ewes resulted in increased
lamb birth weight and elevated the progesterone pattern throughout pregnancy.
Other functional foods and its beneficial effect on health:
Fatty acids found in fish and fish oil have gained interest and publicity for
their role in the prevention and management of cardiovascular disease. Holub
(2002) described in detail the specific fish oil fatty acids and their use
in a variety of clinical trials for the treatment and prevention of atherosclerosis
and cardiovascular disease (Holub, 2002). He defined
the use of fish oil fatty acids in functional foods that were effective in the
prevention of several common diseases. Omega-3 fatty acids, which are found
mostly in fish oil, have been recognized for several decades as important in
nervous system integrity, particularly during development (Holub,
2002; Uauy et al., 1996). Indeed, fatty acids
contained within retinal membrane phospholipids are made up of over 50% omega-3
polyenoic fatty acids, which means that there is a critical demand for these
essential fatty acids at certain developmental stages (Gibson
and Makrides, 2000).
||Diseases affected by omega-3 fatty acid intake and potential
mechanisms of action
|Adopted from Jones (2002)
A diet rich in linoleic acid (an omega-6 fatty acid), but low in linolenic
acid (an omega-3 fatty acid), was shown to result in episodes of numbness, paresthesia,
weakness, inability to walk, pain in the legs and blurred vision in a 6-year-old
girl maintained on total parenteral nutrition for 5 months. When linolenic acid
was returned to the diet, the childs neurological symptoms disappeared.
It was estimated that the requirement for linolenic acid is about 0.54% of energy
intake (Holman et al., 2002). Table
2 shows the diseases affected by omega-3 fatty acid intake and potential
mechanisms of action.
Hasler (1998), IFIC (1998, 2002)
and American Dietetic Association (1999) reported that
many niformations about the other functional foods as follow:
||Garlic has been thought to have medicinal properties for thousands
of years and has been used for a wide variety of purposes. Its best-documented
effect is its potential ability to lower blood cholesterol levels to a modest
extent. Several studies in human volunteers have demonstrated this effect,
but experts disagree on whether a clinically meaningful benefit has been
||Green Tea contains substances, especially polyphenolic components known
as catechins, may reduce the risk of various types of cancer
||Tomatoes and tomato products are the most important sources of the carotenoid
lycopene. Like the better- known carotenoid beta-carotene, lycopene is a
strong antioxidant. Studies in human populations suggest that high intakes
of tomato products or high blood levels of lycopene may be associated with
reduced risks of various types of cancer, especially prostate cancer
||Vegetables might help to protect against age-related macular degeneration,
an eye disease that is an important cause of blindness among older people
||The health claim that the consumption of soy protein is associated with
a reduction in the risk of coronary heart disease is permitted to appear
on packaging for soy protein products under the Dietary Supplement Health
Education Act (DSHEA). The FDA concluded that soy protein that is included
in a diet low in saturated fat and cholesterol may reduce the risk of coronary
heart disease by lowering blood cholesterol levels
||Conjugated linoleic acid (CLA), on the other hand, is a zoochemical. It
is found primarily in dairy products and in meats from ruminant animals
(e.g., beef or lamb). Preliminary research, conducted mostly in experimental
animals, suggests that CLA might help to inhibit breast cancer, increase
muscle mass, decrease body fat and increase bone density. Only a small amount
of research has been conducted on the effects of CLA in humans, however
and the results of that research have not been completely consistent. The
evidence for a beneficial effect of CLA is therefore regarded as weak
||A great deal of scientific evidence indicates that the consumption of
fruits and vegetables is associated with a reduced risk of cancer. Whether
certain types of fruits or vegetables are more beneficial than others is
less clear. One group of vegetables that has been suggested to be particularly
valuable is the cruciferous vegetables. This group includes arugula, bok
choy, broccoli, Brussels sprouts, cabbage, cauliflower, collards, kale,
kohlrabi, mustard greens, radishes, rutabaga, turnip, turnip greens and
||Cranberry juice has been tested for its use to prevent blocking of urinary
catheters, to deodorize urine and to heal skin around stomas and for its
properties as anticarcinogen, antifungal and antioxidant. Most research
has been done on the prevention and treatment of urinary tract infections.
First is was believed that cranberry acted by acidifying urine or by the
bacteriostatic activity of hippuric acid. Later is was discovered that cranberry
juice acted by reducing the adherence of bacteria to the epithelial cells
of membranes. Cranberry juice is more effective in preventing bacteria for
adhering to epithelial cells than removing bacteria already attached to
cell membranes. Therefore, cranberry juice is more effective in preventing
than treating urinary tract infections. Traditionally, cranberry has been
used for the treatment and prophylaxis of urinary tract infections. Research
suggests that its mechanism of action is preventing bacterial adherence
to host cell surface membranes. Cranberry is a safe, well-tolerated herbal
supplement that does not have significant drug interactions (Schlager
et al., 1999; Sobota, 1984)
||Cruciferous vegetables have been thought to be especially good cancer-fighters
because they contain phytochemicals that may protect against cancer, including
isothiocyanates and indoles. These vegetables also provide vitamin C and
fiber and some provide vitamin A-precursor carotenes, folic acid, calcium
and/or iron as well
Finally, the beneficial effects of functional foods can be concluded (IFIC,
1999, 2002) that:
||Reduced risk of cardiovascular diseases
||Reduced risk of cancer
||Reduced risk of other diseases
||Improved mental health
||Quicker reaction time
||Improved fetal health
In conclusion, functional foods will be Hopeful to good health in the future. It have been convincingly demonstrated to be beneficial for their intended purposes when consumed as part of a generally well-balanced and healthful diet. Also, more information must be available to assist consumed for the correct choosing and using the functional foods any to achieve the promised health benefits.
Abbott, R.D., J.D. Curb, B.L. Rodriguez, D.S. Sharp, C.M. Burchfiel and K. Yano, 1996. Effect of dietary calcium and milk consumption on risk of thromboembolic stroke in older middle-aged men. Stroke, 27: 813-818.
Direct Link |
Abdel-Salam, A.M. and S.M. Ahmed, 2007. Preparation and evaluation of formulated functional cheesecake for diabetics. J. Food Agric. Environ., 5: 8-11.
Direct Link |
Abdel-Salam, A.M., A.S. Ammar and W.K. Galal, 2009. Evaluation and properties of formulated low calories functional yoghurt cake. Int. J. Food Agric. Environ., 7: 218-221.
Direct Link |
Abdel-Salam, A.M., M.G. El-Ziney, A.H. Zaghloul, A.Y. Babiker and H.M. Mousa, 2009. The effectiveness of whey proteins mixed with hot-water extract of Artemisia and Capparis spp. against lead acetate-contamination in rats. Food Agric. Environ., 7: 139-141.
Direct Link |
Abdel-Salam, A.M., N. Ammar and A.Z. Abdel-Hamid, 2008. Effectiveness of probiotic labneh supplemented with garlic or onion oil against Schistosoma mansoni in Infected mice. Int. J. Dairy Sci., 3: 97-104.
Al-Sobayil, K.A., M.M. Zeitoun and A.M. Abdel-Salam, 2010. Effectiveness of a functional synbiotic syrup on pregnancy rate, neonatal birth weight and progesterone profile of oestrous-synchronized Najdi ewes. J. Food Agric. Environ., 8: 80-85.
Direct Link |
Al-Sobayil, K.A., M.M. Zeitoun, M.H. Khalil and A.M. Abdel-Salam, 2008. Effect of oral administration of a functional synbiotic syrup on libido, semen characteristics, serum testosterone and liver and kidney function of goats bucks. Asian J. Biol. Sci., 1: 135-139.
Al-Turki, A.I., M.G. El-Ziney and A.M. Abdel-Salam, 2008. Chemical and anti-bacterial characterization of aqueous extracts of oregano, marjoram,sage and licorice and its application in milk and labneh. Food Agric. Environ., 6: 39-44.
Direct Link |
Al-Wabel, N.A., H.M. Mousa, O.H. Omer and A.M. Abdel-Salam, 2008. Biological evaluation of aqueous herbal extracts and stirred yoghurt filtrate mixture against alloxan-induced oxidative stress and diabetes in rats. Int. J. Pharmacol., 4: 135-139.
CrossRef | Direct Link |
American Dietetic Association(ADA), 1999. Functional foods-position of the ADA. J. Am. Diet. Assoc., 99: 1278-1285.
Astrup, A., 2004. Trends in national obesity prevalences in the context of the current global obesity epidemic. Obesity Rev., 5: 173-173.
Beardsworth, A. and T. Keil, 2001. Sociology on the Menu—an Invitation to the Study of Food and Society. Routledge, New York, London.
Belluzzi, A., S. Boschi, C. Brignola, A. Munarini, G. Cariani and F. Miglio, 2000. Polyunsaturated fatty acids and inflammatory bowel disease. Am. J. Clin. Nutr., 71: 339S-342S.
PubMed | Direct Link |
Connor, W.E., 1994. n-3 Fatty Acids and Heart Disease. In: Nutrition and Disease Update: Heart Disease, Kritchevsky, D. and K.K. Caroll (Eds.). AOCS Press, Champaign, Ohio, pp: 1-34.
Connor, W.E., 2000. Importance of n-3 fatty acids in health and disease. Am. J. Clin. Nutr., 71: 171S-175S.
Direct Link |
Dangin, M., Y. Boirie, C. Garcia-Rodenas, P. Gachon and J. Fauquant et al., 2001. The digestion rate of protein is an independent regulating factor of postprandial protein retention. Am. J. Physiol. Endocrinol. Metab, 280: 340-348.
Dawson, A., 2007. Food and the publics health. J. Agric. Environ. Ethic., 20: 225-229.
Dm, M.A., A.C. van Houwelingen and G. Hornstra, 2000. Long-chain polyunsaturated fatty acids, pregnancy and pregnancy outcome. Am. J. Clin. Nutr., 71: 285S-291S.
Direct Link |
Donadio, J.V., 2000. Use of fish oil to treat patients with immunoglobulin A nephropathy. Am. J. Clin. Nutr., 71: 373S-375S.
Eugen, S., 1992. Life of the Ancient Egyptians. University of Oklahoma Press, USA.
Food and Nutrition Board, 1994. Opportunities in the Nutrition and Food Sciences: Research Challenges and the Next Generation of Investigators. National Academy Press, USA.
Ghanem, K.Z., A.M. Abdel-Salam and A.S. Maghraby, 2005. Immunoprophylactic effect of yoghurt-containing probiotic feeding on Schistosoma mansoni infected mice. Polish Food Sci. Nutr. J., 14: 123-126.
Gibson, R.A. and M. Makrides, 2000. n-3 polyunsaturated fatty acid requirements of term infants. Am. J. Clin. Nutr., 71: 251-255.
Gunther, R.T., 1933. The Greek Herbal of Dioscorides. Oxford University Press, Oxford.
Hasler, C.M., 1998. A new look at an ancient concept. Chem. Industry, 2: 84-89.
Direct Link |
Health Canada, 1998. Nutraceuticals/functional foods and health claims on foods. Therapeutic Products Programme and the Food Directorate from the Health Protection Branch. Section 2.2.
Heaney, R.P., K.M. Davie and M.J. Barger-Lux, 2002. Calcium and weight: Clinical studies. J. Am. Coll. Nutr., 21: 152-155.
Holman, R.T., S.B. Johnson and T.F. Hatch, 1982. A case of human linolenic acid deficiency involving neurological abnormalities. Am. J. Clin. Nutr., 35: 617-623.
Holt, P.R., 1999. Dairy foods and prevention of colon cancer: Human studies. J. Am. Coll. Nutr., 18: 379-391.
Holub, B.J., 2002. Clinical nutrition: 4. Omega-3 fatty acids in cardiovascular care. CMA J., 166: 608-615.
Huggett, A.C. and B. Schliter, 1996. Research needs for establishing the safety of functional foods. Nutr. Rev., 54: S143-S148.
Hughes, D.A. and A.C. Pinder, 2000. n-3 Polyunsaturated fatty acids inhibit the antigenpresenting function of human monocytes. Am. J. Clin. Nutr., 71: 357-360.
IFIC. (International Food Information Council) 2002. The consumer view on functional foods: Yesterday and today. Food Insight. May/June 2002.
IFIC. (International Food Information Council), 1998. Backgrounder: Functional Foods. Food Insight Media Guide. International Food Information Council Foundation, Washington, DC,USA.
IFIC. (International Food Information Council), 1999. Functional foods now. International Food Information Council, Washington, DC. http://ific.org/research/funcfoodsres02.cfm.
IFIC. (International Food Information Council), 2002. Functional foods attitudinal research. International Food Information Council, Washington, DC. http://ific.org/research/funcfoodsres02.cfm.
ILSI. (International Life Sciences Institute), 1999. Safety assessment and potential health benefits of food components based on selected scientific criteria. Crit. Rev. Food Sci. Nutr., 39: 203-206.
Direct Link |
Ian, S., 2000. Oxford History of The Ancient Egypt. Oxford University Press, Oxford.
Jones, P.J., 2002. Clinical nutrition: 7. Functional foods-more than just nutrition. JAMC, 166: 1555-1563.
Kalia, A.N., 2005. Text Book of Industrial Pharmacognosy. Oscar Publication, New Delhi, India, ISBN: 8123912404.
Kampman, E., M.L. Slattery, B. Caan and J.D. Potter, 2000. Calcium, vitamin D, sunshine exposure, dairy products and colon cancer risk (United States). Cancer Causes Control, 11: 459-466.
Direct Link |
Koletzko, B., P.J. Aggett, J.G. Bindels, P. Bung and P. Ferre et al., 1998. Growth, development and differentiation: A functional food science approach. Br. J. Nutr., 80: S5-45.
Kremer, J.M., 2000. n-3 fatty acid supplements in rheumatoid arthritis. Am. J. Clin. Nutr., 71: 349S-351S.
Direct Link |
Layman, D.K. and J.I. Baum, 2004. The emerging role of dairy proteins and bioactive peptides in nutrition and health: Dietary protein impact on glycemic control during weight loss. J. Nutr., 134: S968-S973.
Layman, D.K., 2003. The role of leucine in weight loss diets and glucose homeostasis. J. Nutr., 133: 261S-267S.
Mazza, G., 1998. Functional Food, Biochemical and Processing Aspects. Technomic Publishing, Lancaster, PA., pp: 437.
Mccabe, L.D., B.R. Martin, G.P. Mccabe, C.C. Johnston, C.M. Weaver and M. Peacock, 2004. Dairy intakes affect bone density in the elderly. Am. J. Clin. Nutr., 80: 1066-1074.
Meijboom, F.L.B., 2007. Trust, food, and health. Questions of trust at the interface between food and health. J. Agric. Environ. Ethic., 20: 231-245.
Miller, J.I., 1969. The Spice Trade of the Roman Empire. Oxford University Press, Oxford.
Moore, L.L., M.R. Singer, M.L. Bradlee, L. Djousse, M.H. Proctor, L.A. Cupples and R. Ellison, 2005. Intake of fruits vegetables, and dairy products in early childhood and subsequent blood pressure change. Pidemiol, 16: 4-11.
National Academy of Sciences, 1998. Institute of Medicine. Dietary Reference Intakes, Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin and Choline. National Academy Press, Washington, DC, USA.
Sauer, L.A., R.T. Dauchy and D.E. Blask, 2000. Mechanism for the antitumor and anticachectic effects of n-3 fatty acids. Cancer Res., 60: 5289-5295.
Savaiano, D., 2003. Lactose intolerance: A self-fulfilling prophecy leading to osteoporosis. Nutr. Rev., 61: 221-223.
Direct Link |
Schlager, T.A., S. Anderson, J. Trudell and J.O. Hendley, 1999. Effect of cranberry juice on bacteriuria in children with neurogenic bladder receiving intermittent catheterization. J. Pediatr., 135: 698-702.
Direct Link |
Sobota, A.E., 1984. Inhibition of bacterial adherence by cranberry juice: Potential use for the treatment of urinary tract infections. J. Urol., 131: 1013-1016.
Direct Link |
Tannahill, R., 1988. Food in History. Penguin Books, London, ISBN: 0907325 38 6.
Uauy, R., P. Peirano, D. Hoffman, P. Mena, D. Birch and E. Birch, 1996. Role of essential fatty acids in the function of the developing nervous system. Lipids, 31: 167-176.
Verschuren, P.M., 2002. Functional foods: Scientific and global perspectives. British J. Nutr., 88: S125-S130.
Vollmer, W. M., F.M. Sacks and L.P. Svetkey, 2001. New insights into the effects on blood pressure of diets low in salt and high in fruits and vegetables and low-fat dairy. Curr. Control. Trials. Cardiovasc. Med., 2: 71-74.
Direct Link |
WHO, 1998. Obesity: Preventing and managing the global epidemic. Report of a World Health Organization (WHO), Consultation on Obesity, June 1997, Geneva.
Wildman, R.E., 2000. Handbook of Nutraceuticals and Functional Foods. CRC Press, Boca Raton.
Wright, M., 2004. An Introduction to Chinese Herbal Medicine. Greenbank Publications, USA.
Zemel, M.B., 2002. Regulation of adiposity and obesity risk by dietary calcium: Mechanisms and implications. J. Am. Coll. Nutr., 21: 146S-151S.
Direct Link |
Zemel, M.B., 2004. Role of calcium and dairy products in energy partitioning and weight management. Am. J. Clin. Nutr., 79: 907S-912S.
Direct Link |
Zouraris, C., 1998. The Second Deipnosophistis. Athens: Ikaros Publications, New York, pp: 143.